Short echo time single voxel 1H magnetic resonance spectroscopy in the diagnosis and characterisation of pineal tumours in children

2011 ◽  
Vol 57 (6) ◽  
pp. 972-977 ◽  
Author(s):  
Lisa M. Harris ◽  
Nigel P. Davies ◽  
Shaun Wilson ◽  
Lesley MacPherson ◽  
Kal Natarajan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
1H Magnetic Resonance Spectroscopy ◽  
Single Voxel ◽  
Echo Time ◽  
Short Echo Time

Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1h magnetic resonance spectroscopy (MRS) study

2010 ◽  
Vol 51 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Raili Raininko ◽  
Peter Mattsson
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Age Dependence ◽  
Total N ◽  
Metabolite Concentrations ◽  
Repetition Time ◽  
Echo Time ◽  
Short Echo Time

Background: Age- and sex-related changes of metabolites in healthy adult brains have been examined with different 1H magnetic resonance spectroscopy (MRS) methods in varying populations, and with differing results. A long repetition time and short echo time technique reduces quantification errors due to T1 and T2 relaxation effects and makes it possible to measure metabolites with short T2 relaxation times. Purpose: To examine the effect of age on the metabolite concentrations measured by 1H MRS in normal supraventricular white matter using a long repetition time (TR) and a short echo time (TE). Material and Methods: Supraventricular white matter of 57 healthy subjects (25 women, 32 men), aged 13 to 72 years, was examined with a single-voxel MRS at 1.5T using a TR of 6000 ms and a TE of 22 ms. Tissue water was used as a reference in quantification. Results: Myoinositol increased slightly and total N-acetyl aspartate (NAA) decreased slightly with increasing age. Glutamine/glutamate complex (Glx) showed U-shaped age dependence, with highest concentrations in the youngest and oldest subjects. No significant age dependence was found in total choline and total creatine. No gender differences were found. Macromolecule/ lipid (ML) fractions were reliably measurable only in 36/57 or even fewer subjects and showed very large deviations. Conclusion: The concentrations of several metabolites in cerebral supraventricular white matter are age dependent on 1H MRS, even in young and middle-aged people, and age dependency can be nonlinear. Each 1H MRS study of the brain should therefore take age into account, whereas sex does not appear to be so important. The use of macromolecule and lipid evaluations is compromised by less successful quantification and large variations in healthy people.

Short echo time 1 H magnetic resonance spectroscopy of childhood brain tumours

2006 ◽  
Vol 23 (2) ◽  
pp. 163-169 ◽  
Author(s):  
A. C. Peet ◽  
S. Lateef ◽  
L. MacPherson ◽  
K. Natarajan ◽  
S. Sgouros ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Tumours ◽  
Resonance Spectroscopy ◽  
Childhood Brain Tumours ◽  
Echo Time ◽  
Short Echo Time
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