Is WTX a suitable target for cancer therapy?

2010 ◽  
Vol 56 (4) ◽  
pp. 682-682 ◽  
Author(s):  
Daniela Perotti ◽  
Paolo Radice
Keyword(s):  
Cancer Therapy ◽  
Suitable Target

scholarly journals Is Fibroblast Growth Factor Receptor 4 a Suitable Target of Cancer Therapy?

2014 ◽  
Vol 20 (17) ◽  
pp. 2881-2898 ◽  
Author(s):  
Christine Heinzle ◽  
Zeynep Erdem ◽  
Jakob Paur ◽  
Bettina Grasl-Kraupp ◽  
Klaus Holzmann ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Therapy ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Suitable Target

scholarly journals Extracellular ATP: A Feasible Target for Cancer Therapy

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2496
Author(s):  
Valentina Vultaggio-Poma ◽  
Alba Clara Sarti ◽  
Francesco Di Virgilio
Keyword(s):  
Cancer Therapy ◽  
Abc Transporters ◽  
Biological Effects ◽  
Extracellular Atp ◽  
Anion Channels ◽  
Pannexin 1 ◽  
P2 Purinergic Receptors ◽  
Suitable Target ◽  
Active Release ◽  
Connexin Hemichannels

Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells. ATP can be released from cells via both specific and nonspecific pathways. A non-regulated release occurs from dying and damaged cells, whereas active release involves exocytotic granules, plasma membrane-derived microvesicles, specific ATP-binding cassette (ABC) transporters and membrane channels (connexin hemichannels, pannexin 1 (PANX1), calcium homeostasis modulator 1 (CALHM1), volume-regulated anion channels (VRACs) and maxi-anion channels (MACs)). Extracellular ATP acts at P2 purinergic receptors, among which P2X7R is a key mediator of the final ATP-dependent biological effects. Over the years, P2 receptor- or ecto-nucleotidase-targeting for cancer therapy has been proposed and actively investigated, while comparatively fewer studies have explored the suitability of TME ATP as a target. In this review, we briefly summarize the available evidence suggesting that TME ATP has a central role in determining tumor fate and is, therefore, a suitable target for cancer therapy.

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

Tetracycline Resolves Cancer Therapy Rash

2007 ◽  
Vol 37 (14) ◽  
pp. 23
Author(s):  
KERRI WACHTER
Keyword(s):  
Cancer Therapy
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