scholarly journals Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease

2009 ◽  
Vol 53 (3) ◽  
pp. 479-481 ◽  
Author(s):  
Amber Mayfield Yates ◽  
Jane S. Hankins ◽  
Nicole A. Mortier ◽  
Banu Aygun ◽  
Russell E. Ware
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Splenic Sequestration ◽  
Aplastic Crisis ◽  
Transient Aplastic Crisis

scholarly journals Acute kidney injury during parvovirus B19-induced transient aplastic crisis in sickle cell disease

2018 ◽  
Vol 93 (8) ◽  
pp. E198-E200 ◽  
Author(s):  
Jamie Oakley ◽  
Rima Zahr ◽  
Inmaculada Aban ◽  
Varsha Kulkarni ◽  
Rakesh P. Patel ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Kidney Injury ◽  
Cell Disease ◽  
Aplastic Crisis ◽  
Transient Aplastic Crisis

scholarly journals A case of severe multi-system disease in a sickle cell SC patient caused by parvovirus B19 infection

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Mohamed Almuqamam ◽  
◽  
Swetha Madhavarapu ◽  
Nataly Apollonsky ◽  
◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Parvovirus B19 ◽  
Acute Infection ◽  
Organ Injury ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Splenic Sequestration ◽  
Increased Risk ◽  
Parvovirus B19 Infection

Sickle Cell Disease (SCD) is an inherited hemoglobinopathy, which results in production of abnormal hemoglobin S. HbSC disease is a variant of SCD, which shares a similar clinical complication profile to HbSS disease, but often thought to be a milder condition. In patients with SCD, Hb S in deoxygenated state undergoes polymerization, leading to hemolysis, vaso-occlusive events, and eventually end-organ damage. Among other complications in patients with SCD is increased risk of complications caused by parvovirus B19. We present a case of a 14-year-old female with HbSC disease who presented to the emergency room with complaint of abdominal pain and found to have splenic sequestration. Splenic sequestration progressed rapidly, Hemoglobin (hb) dropped to 4.6 g/dl and acute chest syndrome (ACS) developed. She was treated following the ACS protocol, received 4 units of Packed Red Blood Cells (PRBC) and subsequently underwent a single volume PRBC exchange transfusion. Considering her unusual presentation, with severe ARDS from alveolar hemorrhage requiring mechanical ventilation and multi-organ injury, several autoimmune and infectious conditions with a cytokine storm component including COVID-19 disease, were considered. Results of viral testing revealed parvovirus B19 IgM antibodies signifying an acute infection. She fully recovered with supportive care and was discharged home. Multisystem involvement simulating connective tissue disorders or malignancies with acute parvovirus B19 infection has been reported and is considered extremely rare. To our knowledge, there were no reports of pediatric patients with SC disease presenting with splenic sequestration and ACS in the setting of parvovirus B19 multisystem disease. Keywords: sickle cell disease; acute respiratory distress syndrome; acute chest syndrome; parvovirus B19.

CT imaging of splenic sequestration in sickle cell disease

2000 ◽  
Vol 30 (12) ◽  
pp. 830-833 ◽  
Author(s):  
S. Sheth ◽  
C. Ruzal-Shapiro ◽  
S. Piomelli ◽  
W. E. Berdon
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Ct Imaging ◽  
Cell Disease ◽  
Splenic Sequestration

Prevalence and predictive factors of splenic sequestration crisis among 423 pediatric patients with sickle cell disease in Tunisia

2020 ◽  
Vol 80 ◽  
pp. 102374
Author(s):  
Monia Ben Khaled ◽  
Monia Ouederni ◽  
Yosra Mankai ◽  
Samia Rekaya ◽  
Ilhem Ben Fraj ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Predictive Factors ◽  
Pediatric Patients ◽  
Cell Disease ◽  
Splenic Sequestration

scholarly journals Clinical events in the first decade in a cohort of infants with sickle cell disease. Cooperative Study of Sickle Cell Disease [see comments]

Blood ◽  
1995 ◽  
Vol 86 (2) ◽  
pp. 776-783 ◽  
Author(s):  
FM Gill ◽  
LA Sleeper ◽  
SJ Weiner ◽  
AK Brown ◽  
R Bellevue ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Clinical Course ◽  
The United States ◽  
Beta Thalassemia ◽  
Acute Chest Syndrome ◽  
Cooperative Study ◽  
Cell Disease ◽  
Splenic Sequestration ◽  
Clinical Events

Within the Cooperative Study of Sickle Cell Disease, 694 infants with confirmed sickle cell disease were enrolled at less than 6 months of age. Information about the nature and frequency of complications was collected prospectively over a 10-year period. Painful crises and acute chest syndrome were the most common sickle cell-related events in homozygous sickle cell anemia (SS), hemoglobin SC disease (SC), and S beta thalassemia patients (overall incidence in SS patients of 32.4 and 24.5 cases per 100 person-years, respectively). Bacteremia occurred most frequently in SS children under 4 years of age and in SC patients less than 2 years of age. The mortality rate was low in this cohort compared with that found in previous reports. Twenty children, all with Hb SS, died (1.1 deaths per 100 person-years among SS patients). Infection, most commonly with Streptococcus pneumoniae and Hemophilus influenzae, caused 11 deaths. Two children died of splenic sequestration, 1 of cerebrovascular accident, and 6 of unclear causes. Two patients underwent cholecystectomies, and 17 underwent splenectomies after one or more splenic sequestration crises. The experience of this cohort should reflect closely the true clinical course of those children with Hb SS and Hb SC disease who are observed in sickle cell centers in the United States.

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