A prospective, blinded analysis of A-PROTEIN (recoverin or CAR protein) levels in pediatric patients with central nervous system tumors

2009 ◽  
Vol 53 (3) ◽  
pp. 343-347
Author(s):  
Peter Manley ◽  
Xiaochun Li ◽  
Christopher Turner ◽  
Susan Chi ◽  
Mary Ann Zimmerman ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pediatric Patients ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
Protein Levels

Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection

2021 ◽  
pp. 1-8
Author(s):  
Al Flores-Bustamante ◽  
Laura Hernández-Regino ◽  
Manuel-De-Jesús Castillejos-López ◽  
Daniel Martínez-Rodríguez ◽  
Arnoldo Aquino-Gálvez ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Overall Survival ◽  
Nervous System ◽  
Surgical Resection ◽  
Pediatric Patients ◽  
Poor Response ◽  
Response To Treatment ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
Lymphocyte Ratio

BACKGROUND: Changes in neutrophil to lymphocyte ratio (ΔNLR) have been used as a clinical tool for stratification and prognosis of patients with solid tumors, there is scarce evidence of their clinical relevance in patients with tumors of the central nervous system who have also undergone surgical resection. OBJECTIVE: Determine if (ΔNLR) are associated with poor response to treatment and worse prognosis in pediatric patients with central nervous system tumors (CNST) who underwent surgical resection. METHODS: We performed a retrospective cohort study; demographic, clinical, and hematological variables were evaluated, Kaplan-Meier survival curves and Cox proportional hazards regression model were performed to evaluate prognosis. RESULTS: The ΔNLR cutoff value obtained through the third interquartile range was 4.30; The probability of survival and complete response to treatment was different between patients with high ΔNLR when compared to patients with low ΔNLR (p= 0.013, p=≪ 0.001, respectively). A high ΔNLR behaved as an independent predictor of worse Overall Survival (HR 2,297; 95% CI: 1,075–4.908, p= 0.032). CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.

scholarly journals Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors

2021 ◽  
Vol 10 (3) ◽  
pp. 843-856
Author(s):  
Leo Mascarenhas ◽  
Chitose Ogawa ◽  
Theodore W. Laetsch ◽  
Brenda J. Weigel ◽  
Michael W. Bishop ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pediatric Patients ◽  
Phase 1 ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
Phase 1 Trial

Pharmacokinetics of O6-benzylguanine in Pediatric Patients with Central Nervous System Tumors

2004 ◽  
Vol 10 (15) ◽  
pp. 5072-5075 ◽  
Author(s):  
Kathleen Neville ◽  
Susan Blaney ◽  
Mark Bernstein ◽  
Patrick Thompson ◽  
Denise Adams ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pediatric Patients ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors
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