Exercise echocardiography reveals subclinical cardiac dysfunction in young adult survivors of childhood acute lymphoblastic leukemia

2007 ◽  
Vol 49 (6) ◽  
pp. 835-840 ◽  
Author(s):  
M. Jarfelt ◽  
V. Kujacic ◽  
D. Holmgren ◽  
R. Bjarnason ◽  
B. Lannering
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Cardiac Dysfunction ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Exercise Echocardiography ◽  
Young Adult Survivors

Endothelial Function in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

2008 ◽  
Vol 30 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Donald R. Dengel ◽  
Kirsten K. Ness ◽  
Stephen P. Glasser ◽  
Eric B. Williamson ◽  
K. Scott Baker ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Endothelial Function ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Young Adult Survivors

Comparison of psychologic outcome in adult survivors of childhood acute lymphoblastic leukemia versus sibling controls: a cooperative Children's Cancer Group and National Institutes of Health study.

1997 ◽  
Vol 15 (2) ◽  
pp. 547-556 ◽  
Author(s):  
L K Zeltzer ◽  
E Chen ◽  
R Weiss ◽  
M D Guo ◽  
L L Robison ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Lymphoblastic Leukemia ◽  
Negative Mood ◽  
Affective State ◽  
Adult Survivors ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Childhood All ◽  
Cancer Group ◽  
Young Adult Survivors

PURPOSE To determine psychologic outcome, with the focus on emotional or mood state, of young adult survivors of childhood acute lymphoblastic leukemia (ALL) compared with sibling controls and to identify vulnerable subgroups at highest risk for negative mood. PATIENTS AND METHODS Adult survivors (n = 580), aged > or = 18 years, who were treated before age 20 years on Children's Cancer Group (CCG) protocols for ALL and 396 sibling controls were administered a structured telephone interview and the Profile of Moods State (POMS), a standardized measure of affective state. RESULTS Survivors had higher total mood scores (which indicates greater negative mood) than sibling controls (P<.01) and reported more tension (P< .01), depression (P<.01), anger (P<.01), and confusion (P<.01), but not more fatigue or less vigor. Female, minority, and unemployed survivors reported the highest total mood disturbance. Overall, survivors were more likely to be unemployed (P<.05) or working less than half-time (P<.01) compared with controls. CONCLUSION This large, sibling-controlled, multisite study of young adult survivors of childhood ALL treated on CCG protocols after 1970 found significant increased negative mood in survivors, not accounted for by reported energy level differences, which suggests that these emotional effects are not likely the result of current illness. Survivors are less likely to be fully employed. Female, minority, and unemployed survivors are at greatest risk for emotional sequelae, a finding that indicates the need for targeted, preventive intervention.

scholarly journals Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging

Cancer ◽  
2017 ◽  
Vol 123 (21) ◽  
pp. 4207-4214 ◽  
Author(s):  
Hany Ariffin ◽  
Mohamad Shafiq Azanan ◽  
Sayyidatul Syahirah Abd Ghafar ◽  
Lixian Oh ◽  
Kee Hie Lau ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Chronic Inflammation ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Cellular Aging ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Show Evidence ◽  
Young Adult Survivors

Long-term Neurocognitive Outcomes in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

2011 ◽  
Vol 33 (6) ◽  
pp. 450-458 ◽  
Author(s):  
Kim Edelstein ◽  
Norma DʼAgostino ◽  
Lori J. Bernstein ◽  
Paul C. Nathan ◽  
Mark L. Greenberg ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Neurocognitive Outcomes ◽  
Young Adult Survivors
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