scholarly journals Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H

2008 ◽  
Vol 50 (4) ◽  
pp. 917-919 ◽  
Author(s):  
Mwe Mwe Chao ◽  
John E. Levine ◽  
James L. Ferrara ◽  
Laura Cooling ◽  
Kenneth R. Cooke ◽  
...  
Keyword(s):  
Cord Blood ◽  
Successful Treatment ◽  
Immune Hemolysis ◽  
Cord Blood Transplant ◽  
Unrelated Cord Blood

scholarly journals Results of Unrelated Cord Blood Transplant in Fanconi Anemia Patients: Risk Factor Analysis for Engraftment and Survival

2007 ◽  
Vol 13 (9) ◽  
pp. 1073-1082 ◽  
Author(s):  
Eliane Gluckman ◽  
Vanderson Rocha ◽  
Irina Ionescu ◽  
Marc Bierings ◽  
Richard E. Harris ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
Cord Blood ◽  
Fanconi Anemia ◽  
Risk Factor Analysis ◽  
Cord Blood Transplant ◽  
Unrelated Cord Blood

Efficacy and safety of micafungin in unrelated cord blood transplant recipients

2019 ◽  
Vol 98 (11) ◽  
pp. 2593-2600
Author(s):  
Takeo Yasu ◽  
Takaaki Konuma ◽  
Maki Oiwa-Monna ◽  
Mai Mizusawa ◽  
Masamichi Isobe ◽  
...  
Keyword(s):  
Cord Blood ◽  
Efficacy And Safety ◽  
Transplant Recipients ◽  
Cord Blood Transplant ◽  
Unrelated Cord Blood

The Effect of Obesity On Outcome of Unrelated Cord Blood Transplant in Children with Malignant Diseases.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 2278-2278
Author(s):  
S. Pine Meghann ◽  
Li Wang ◽  
Frank Harrell ◽  
Richard Ho ◽  
Jennifer Domm ◽  
...  
Keyword(s):  
Cord Blood ◽  
Performance Status ◽  
Chronic Gvhd ◽  
Hla Antigens ◽  
Normal Weight ◽  
Obese Patients ◽  
Malignant Diseases ◽  
Cord Blood Transplant ◽  
Cord Blood Unit ◽  
Unrelated Cord Blood

Abstract Abstract 2278 Poster Board II-255 Obesity has become a pandemic in the US, affecting both children and adults. In the adult population, evidence suggests that obesity has an adverse impact on outcomes of hematopoietic stem cell transplant for various malignancies. We investigated the influence of obesity on children undergoing unrelated cord blood transplant utilizing data from the Cord Blood Transplant Study. To our knowledge, no data exists on the effect obesity has on key prognostic indicators for cord blood transplant for malignant diseases in children. There were 191 patients '18 years of age with malignant diseases prospectively enrolled on a National Heart Lung Blood Institute (NHLBI) sponsored cord blood transplant study between 1999 and 2003. Data set was obtained after signed agreement with the NHLBI and local IRB approval. All patients received myeloablative preparative regimens with either total body irradiation and cyclophosphamide (N=172) or busulfan and melphalan (N=19). In addition, all patients received anti-thymocyte globulin as part of their conditioning regimens. Graft versus host disease (GVHD) prophylaxis included cyclosporine and prednisone. Children were classified into groups according to body mass index (BMI) percentile. Normal weight was defined as BMI between the 5th and 85th percentile, overweight between the 85th and 95th percentile, obesity above 95th percentile for age and gender according to the Center for Disease Control and Prevention (CDC) guidelines. For the overall survival (OS) and disease free survival (DFS), the Cox regression model was used to test the effect of BMI while controlling for age, gender, performance status (<90 versus ≥90), HLA match (≤4/6 versus ≥5/6 HLA match), total nucleated cell count (TNC) per kg infused and CMV status. For neutrophil and platelet engraftment, transplant related mortality (TRM), grade II-IV acute GVHD, and chronic GVHD, competing risks regression analyses were used to test effect of BMI while controlling for other covariates. The median age was 7.59 years (range 2.07 – 17.90) with 113 (59%) male. 160 patients (84%) had a performance status of ≥90. 51 patients (27%) had acute myelogenous leukemia (AML), 109 patients (57%) had acute lymphoblastic leukemia (ALL) and 30 patients (16%) had other malignant diseases. 119 patients (62%) received a cord blood unit matched at 3/6 or 4/6 HLA antigens and 72 patients (38%) received a cord blood unit matched at 5/6 or 6/6 HLA antigens. The median TNC per kg infused was 5.2 × 107/kg (range 0.15-80.9 × 107/kg). Of the 191 total patients who were classified by their BMI percentiles, 117 patients (61%) were normal weight, 35 patients (18%) were overweight and 39 patients (20%) were obese. The two groups were not significantly different in sex distribution (p=0.25), diagnosis (p=0.13), performance status (p=0.91), median TNC received (p=0.49) or CMV status (p=0.47). Obese patients were significantly younger with a median age of 5.7 years compared to 8.9 years in normal weight children (p=0.002). Time to neutrophil and platelet engraftment, TRM, risk of grade II-IV acute GVHD, DFS and OS were not significantly different in overweight or obese patients compared to normal weight patients. There was a trend towards increased risk of chronic GVHD in obese patients (p=0.045) compared to normal weight patients. In conclusion, obesity has no significant effect on multiple outcomes after unrelated cord blood transplant in children with malignant diseases. Disclosures: No relevant conflicts of interest to declare.

Unrelated cord blood transplant for refractory langerhan cell histocytosis

2000 ◽  
Vol 22 (4) ◽  
pp. 385
Author(s):  
R. Nagarajan ◽  
J. P. Neglia ◽  
N. K.C. Ramsay ◽  
K. S. Baker
Keyword(s):  
Cord Blood ◽  
Cord Blood Transplant ◽  
Unrelated Cord Blood

scholarly journals Donor-derived 47, XXY in an unrelated cord blood transplant recipient

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 72 ◽  
Author(s):  
Kuniki Kawaguchi ◽  
Takayuki Nakamura ◽  
Masayuki Nohara ◽  
Satoko Koteda ◽  
Kei Nomura ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Cord Blood ◽  
Cord Blood Transplant ◽  
Unrelated Cord Blood
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