Sudden onset blindness in sickle cell disease due to retinal artery occlusion

2008 ◽  
Vol 50 (3) ◽  
pp. 624-627 ◽  
Author(s):  
Robert I. Liem ◽  
Diane M. Calamaras ◽  
Manpreet S. Chhabra ◽  
Beatrice Files ◽  
Caterina P. Minniti ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Sudden Onset ◽  
Cell Disease ◽  
Retinal Artery

scholarly journals Concurrent Bilateral Central Retinal Artery Occlusion Secondary to Sickle Cell Crisis

2021 ◽  
Vol 9 ◽  
pp. 232470962110283
Author(s):  
Gowri Renganathan ◽  
Piruthiviraj Natarajan ◽  
Lela Ruck ◽  
Roberto Prieto ◽  
Bharat Ved Prakash ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Vision Loss ◽  
Central Retinal Artery Occlusion ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Cell Disease ◽  
Sickle Cell Crisis ◽  
History Of ◽  
Retinal Artery

Vascular occlusive crisis with a concurrent vision loss on both eyes is one of the most devastating disability for sickle cell disease patients. Reportedly occlusive crisis in the eyes is usually temporary whereas if not appropriately managed can result in permanent vision loss. A carefully managed sickle cell crisis could prevent multiple disabilities including blindness and stroke. We report a case of a 24-year-old female with a history of sickle cell disease who had acute bilateral vision loss during a sickle crisis and recovered significantly with a timely emergent erythrocytapheresis.

Abstract T MP110: Central Retinal Artery Occlusion in Patients with Sickle Cell Disease

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Hashim Khan ◽  
Morad Chughtai ◽  
Ahmed A Malik ◽  
Adnan I Qureshi ◽  
Fareed K Suri
Keyword(s):  
Risk Factors ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Central Retinal Artery Occlusion ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Cell Disease ◽  
History Of ◽  
Retinal Artery

Objective: To determine the rate of and risk factors for incident central retinal artery occlusion (CRAO) among patients with sickle cell disease enrolled in a large cohort with longitudinal follow-up. Background: Sickle cell disease increases the risk of ischemic stroke among women but the risk of CRAO is not studied. Design/Methods: A total of 4085 patients from newborns to 77 years-old, were enrolled in Phase 1 of Cooperative Study of Sickle Cell Disease from 23 centers across the US. Participants underwent a baseline examination for assessment of demographics, prior medical history, lab assessments, and clinical data. Post baseline data included routine follow-up examinations, measures of organ damage, and collection of acute and chronic complications. The risk factors for CRAO were identified using Cox Proportional Hazards analysis. Results: A total of 9 (0.002%) of 4085 patients with sickle cell disease developed CRAO over a mean follow-up of 5.2 (95% CI 0.9 - 11.3) months, with an estimated incidence of 0.02 per 100 patient years. The incidence of CRAO was 0.03 per 100 patient years and 0.05 per 100 patient years in men and women, respectively. The history of previous stroke (2.6% versus 0.0%, p=0.7) and the proportion of patients diagnosed with large arterial occlusive disease (55.6% versus 7.7%, p=<0.001) was greater in those who developed CRAO compared to those who did not develop CRAO. History of exchange transfusions (2.7 % versus 22.2 %, p=0.02) and cigarette smoking (13.7 % versus 22.2 %, p =0.4) were more common among patients who developed CRAO. The hematocrit (%) (mean ± SD) was similar between patients who did or did not develop CRAO (29.5 ± 9.6 versus 27.3 ± 5.6, p=0.3). At completion of follow-up, 22.2% (n=2) patients with CRAO reported disability compared with 11.1% (n=455) patients without CRAO (p=0.7) Conclusions: The incidence of CRAO is relatively high among patients with sickle cell disease and was associated with disability.

Imaging Methods in Retinal Artery Occlusion

2020 ◽  
pp. 13-17
Keyword(s):  
Imaging Techniques ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Sudden Onset ◽  
Diagnosis And Treatment ◽  
Fundus Fluorescein Angiography ◽  
Imaging Methods ◽  
Invasive Method ◽  
Retinal Microcirculation ◽  
Retinal Artery

Advances in ophthalmic imaging methods shed light on the management of retinal artery occlusion (RAO). RAT is an ocular emergency that can cause painless, sudden onset, unilateral vision, or loss of visual field. RAO requires early diagnosis and treatment. Fundus fluorescein angiography (FFA), which can be used in diagnosis and follow-up, is an invasive method requiring intravenous dye application which can cause side effects. In recent years, optical coherence tomography angiography (OCTA) has become widely available as an alternative to FFA in various ophthalmologic diseases. OCTA is a new type of angiography used for fundus imaging. It is a non-invasive method for measuring and quantifying the retinal microcirculation without the use of dyes. Many other imaging modalities used in ophthalmology clinics have been used in many areas of diagnosis and treatment of RAO patients. This review deals with the results of different imaging techniques in patients with RAO.

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