Bone mineral density in children and young adults with beta-thalassemia major conventionally treated—RESPONSE

2006 ◽  
Vol 47 (1) ◽  
pp. 115-115
Author(s):  
A. Lal ◽  
E.B. Fung ◽  
Z. Pakbaz ◽  
E.P. Vichinsky
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Mineral Density ◽  
Beta Thalassemia Major ◽  
Children And Young Adults

Bone mineral density in children and young adults with beta-thalassemia major conventionally treated

2006 ◽  
Vol 47 (1) ◽  
pp. 113-114 ◽  
Author(s):  
Athanasios Christoforidis ◽  
Emmanouil Hatzipantelis ◽  
Ioanna Tsatra ◽  
Eirini Kazantzidou ◽  
George Katzos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Mineral Density ◽  
Beta Thalassemia Major ◽  
Children And Young Adults

scholarly journals EVALUATION OF GLUTATHIONE-S-TRANSFERASE P1 POLYMORPHISM AND ITS RELATION TO BONE MINERAL DENSITY IN EGYPTIAN CHILDREN AND ADOLESCENTS WITH BETA- THALASSEMIA MAJOR

2016 ◽  
Vol 8 ◽  
pp. 2016004 ◽  
Author(s):  
Seham Ragab
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Z Score ◽  
Glutathione S Transferase ◽  
Mineral Density ◽  
Beta Thalassemia Major ◽  
Egyptian Children ◽  
Z Scores

Background:Osteoporosis is a major problem in beta thalassemia major (TM) patients. Increased oxidative stress and its controlling genes were linked to osteoporosis. Glutathione S-transferase P1 (GSTP1),Ile105 Val variant  is a functional  mutation with  reduced ant-oxidative property  .No data are available about this variant  or its association with osteoporosis  among thalassemia patients yet. Objectives: The aim of this study was to investigate Ile105Val polymorphism and its possible association with bone mineral density (BMD) values in a group of TM  children. Methods:Thirty five TM patients and 30 age and sex matched healthy controls were included. Liver and renal functions, serum ferritin, calcium, phosphorous, alkaline phosphatase and osteocalcin were assayed. BMD was determined by DXA with calculation of  Z-scores at lumbar spine (Ls) and femoral neck (Fn).Height for age z- score (HAZ) adjusted BMD Z-scores were considered . GSTP1 Ile105Val polymorphism was studied by polymerase chain reaction-restriction fragment length polymorphism. Results:The relative frequency of 105 Val allele was significantly higher in TM patients than the controls (P<0.0001). Significant association between genotype subgroups and BMD parameters was detected. Mutant homozygotes had significant lower BMD , Z –score and haz -adjusted BMD  Z-score at both Ls and Fn compared to wild homozygotes ( Ps =0.029, 0.008, 0.011, 0.001,0.02, 0.001) with significant higher osteocalcin level compared to heterozygotes and wild homozygotes (P=0.012 and P=0.013,respectively). Conclusion:  The results indicated that 105Val allele was frequent among TM patients and could increase their susceptibility to osteoporosis. Large sample studies are required to confirm these findings.  

scholarly journals Zoledronic Acid for Treatment of Low Bone Mineral Density in Patients with Beta Thalassemia Major

2018 ◽  
Vol 34 (4) ◽  
pp. 648-652
Author(s):  
Rahul Naithani ◽  
Tulika Seth ◽  
Nikhil Tandon ◽  
Jagdish Chandra ◽  
V. P. Choudhry ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Zoledronic Acid ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Beta Thalassemia Major

scholarly journals Fractures and Low Bone Mineral Density in Patients with Beta Thalassemia Major

2017 ◽  
Vol 34 (1) ◽  
pp. 163-165 ◽  
Author(s):  
Rahul Naithani ◽  
Tulika Seth ◽  
Nikhil Tandon ◽  
Jagdish Chandra ◽  
H. Pati ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Beta Thalassemia Major

Bone mineral density in children with beta-thalassemia major in Diyarbakir

Bone ◽  
2011 ◽  
Vol 49 (4) ◽  
pp. 819-823 ◽  
Author(s):  
Ayfer Gözü Pirinççioğlu ◽  
Veysi Akpolat ◽  
Orhan Köksal ◽  
Kenan Haspolat ◽  
Murat Söker
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Mineral Density ◽  
Beta Thalassemia Major

Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults

2004 ◽  
Vol 74 (6) ◽  
pp. 495-500 ◽  
Author(s):  
A. M. Boot ◽  
I. M. van der Sluis ◽  
S. M. P. F. de Muinck Keizer-Schrama ◽  
J. B. J. van Meurs ◽  
E. P. Krenning ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Estrogen Receptor ◽  
Young Adults ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Estrogen Receptor Α ◽  
Healthy Children ◽  
Mineral Density ◽  
Children And Young Adults ◽  
Estrogen Receptor Α Gene

Activin-A is elevated in patients with thalassemia major and double heterozygous sickle cell/beta-thalassemia and correlates with markers of hemolysis and bone mineral density

2019 ◽  
Vol 98 (7) ◽  
pp. 1583-1592
Author(s):  
Ersi Voskaridou ◽  
Ioannis Ntanasis-Stathopoulos ◽  
Dimitrios Christoulas ◽  
Maria Dimopoulou ◽  
Veroniki Komninaka ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Sickle Cell ◽  
Bone Mineral ◽  
Thalassemia Major ◽  
Activin A ◽  
Beta Thalassemia ◽  
Mineral Density

Bone Mineral Density in Children and Young Adults with Crohnʼs Disease

1999 ◽  
Vol 5 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Edisio J. Semeao ◽  
Abbas F. Jawad ◽  
Babette S. Zemel ◽  
Kristin M. Neiswender ◽  
David A. Piccoli ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Mineral Density ◽  
Children And Young Adults
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