Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: A case report and review of the literature

2005 ◽  
Vol 45 (3) ◽  
pp. 333-339 ◽  
Author(s):  
Hidemi Shimonodan ◽  
Jun Nagayama ◽  
Yoshihisa Nagatoshi ◽  
Michiki Hatanaka ◽  
Akiko Takada ◽  
...  
Keyword(s):  
Case Report ◽  
Parathyroid Hormone ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Review Of The Literature ◽  
Osteolytic Lesions ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide

scholarly journals Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature

2015 ◽  
Vol 11 (2) ◽  
pp. 1143-1145 ◽  
Author(s):  
DANYI XU ◽  
GUANHUA XU ◽  
LIQIN XU ◽  
HENG CAO ◽  
BEI XU ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Review Of The Literature

scholarly journals Richter’s Syndrome with Hypercalcemia Induced by Tumor-Associated Production of Parathyroid Hormone-Related Peptide

2017 ◽  
Vol 10 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Naoki Watanabe ◽  
Hajime Yasuda ◽  
Soji Morishita ◽  
Yasuo Aota ◽  
Junichi Tomomatsu ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Lymphocytic Leukemia ◽  
Rt Pcr ◽  
Adult T Cell Leukemia ◽  
Related Peptide ◽  
Associated Production ◽  
Humoral Hypercalcemia ◽  
Pcr Method ◽  
Parathyroid Hormone Related Peptide ◽  
Richter’S Syndrome

Humoral hypercalcemia due to parathyroid hormone-related peptide (PTHrP) elevation is a well-known complication of various malignancies, but the situation is rare concerning hematological malignancies except for adult T-cell leukemia/lymphoma. We report a case of Richter’s syndrome with humoral hypercalcemia, and demonstrate by reverse transcription polymerase chain reaction (RT-PCR) that peripheral blood PTHrP levels were 2,500-fold higher compared to healthy controls. PTHrP production by tumor cells in chronic lymphocytic leukemia (CLL) and Richter’s syndrome has been previously demonstrated by nonquantitative methods such as immunohistochemistry and northern blot analysis, but this is the first report using the RT-PCR method. The presented case did not have hypercalcemia when initially diagnosed as small lymphocytic lymphoma (SLL), and as reported earlier, the development of hypercalcemia may be an indication of the transformation to Richter’s syndrome in patients with CLL/SLL.

Case Report of Multimodality Treatment for Metastatic Parathyroid Hormone-related Peptide-secreting Pancreatic Neuroendocrine Tumour

2014 ◽  
Vol 100 (4) ◽  
pp. e153-e156 ◽  
Author(s):  
Roberta Elisa Rossi ◽  
Keval Naik ◽  
Shaunak Navalkissoor ◽  
Charles Imber ◽  
James O'Beirne ◽  
...  
Keyword(s):  
Case Report ◽  
Parathyroid Hormone ◽  
Neuroendocrine Tumour ◽  
Multimodality Treatment ◽  
Related Peptide ◽  
Pancreatic Neuroendocrine Tumour ◽  
Parathyroid Hormone Related Peptide
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