Immunologic monitoring of maintenance therapy for acute lymphoblastic leukaemia in children?preliminary report

2004 ◽  
Vol 42 (5) ◽  
pp. 416-420 ◽  
Author(s):  
Wlodzimierz Luczynski ◽  
Anna Stasiak-Barmuta ◽  
Maryna Krawczuk-Rybak
Keyword(s):  
Maintenance Therapy ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Preliminary Report ◽  
Immunologic Monitoring

scholarly journals Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Santeri Karppinen ◽  
Olli Lohi ◽  
Matti Vihola
Keyword(s):  
Maintenance Therapy ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Leukocyte Count ◽  
Peripheral Blood Leukocyte ◽  
Reactive Protein ◽  
Leukocyte Counts ◽  
Nonlinear State Space Models ◽  
Blood Leukocyte ◽  
The Individual

AbstractMaintenance chemotherapy with oral 6-mercaptopurine and methotrexate remains a cornerstone of modern therapy for acute lymphoblastic leukaemia. The dosage and intensity of therapy are based on surrogate markers such as peripheral blood leukocyte and neutrophil counts. Dosage based leukocyte count predictions could provide support for dosage decisions clinicians face trying to find and maintain an appropriate dosage for the individual patient. We present two Bayesian nonlinear state space models for predicting patient leukocyte counts during the maintenance therapy. The models simplify some aspects of previously proposed models but allow for some extra flexibility. Our second model is an extension which accounts for extra variation in the leukocyte count due to a treatment adversity, infections, using C-reactive protein as a surrogate. The predictive performances of our models are compared against a model from the literature using time series cross-validation with patient data. In our experiments, our simplified models appear more robust and deliver competitive results with the model from the literature.

scholarly journals Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia.

1987 ◽  
Vol 62 (2) ◽  
pp. 172-176 ◽  
Author(s):  
J M Chessells ◽  
A D Leiper ◽  
K Tiedemann ◽  
R M Hardisty ◽  
S Richards
Keyword(s):  
Maintenance Therapy ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Oral Methotrexate

Can anthocyanins improve maintenance therapy of Ph+acute lymphoblastic leukaemia?

2013 ◽  
Vol 90 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Joachim Köchling ◽  
Manuel Schmidt ◽  
Yvonne Rott ◽  
Michael Sagner ◽  
Hendrik Ungefroren ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia
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