scholarly journals The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies

2021 ◽  
Author(s):  
Michal Kovac ◽  
Baptiste Ameline ◽  
Sebastian Ribi ◽  
Monika Kovacova ◽  
William Cross ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Targeted Treatment

scholarly journals A molecular transmission network of recent hepatitis C infection in people with and without HIV: Implications for targeted treatment strategies

2016 ◽  
Vol 24 (5) ◽  
pp. 404-411 ◽  
Author(s):  
S. R. Bartlett ◽  
J. O. Wertheim ◽  
R. A. Bull ◽  
G. V. Matthews ◽  
F. M. J. Lamoury ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Treatment Strategies ◽  
Targeted Treatment ◽  
Transmission Network ◽  
Hepatitis C Infection

Therapeutic Targets and Opportunities in Endometrial Cancer: Update on Endocrine Therapy and Nonimmunotherapy Targeted Options

2020 ◽  
pp. 245-255
Author(s):  
Helen J. MacKay ◽  
Victor Rodriguez Freixinos ◽  
Gini F. Fleming
Keyword(s):  
Endometrial Cancer ◽  
Endocrine Therapy ◽  
Metastatic Disease ◽  
Early Stage ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Targeted Treatment ◽  
Early Stage Disease ◽  
New Era ◽  
Stage Disease

Worldwide, the incidence of endometrial cancer is increasing. Although the prognosis remains good for patients diagnosed with early-stage disease, for those diagnosed with recurrent or metastatic disease, options have been limited, and prognosis is short. Optimizing and identifying new well-tolerated treatments for women living with endometrial cancer is a top priority. A new era is dawning where we are starting to see the integration of clinically relevant genomic and pathologic data to inform and refine treatment strategies for women with endometrial cancer. Here, we focus on reviewing nonimmunotherapy-based targeted treatment options and emerging directions for women with endometrial cancer.

IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies

Leukemia ◽  
2018 ◽  
Vol 32 (5) ◽  
pp. 1249-1253 ◽  
Author(s):  
Manja Meggendorfer ◽  
Luca Vincenzo Cappelli ◽  
Wencke Walter ◽  
Claudia Haferlach ◽  
Wolfgang Kern ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Targeted Treatment

scholarly journals Molecular Characteristics of Pancreatic Ductal Adenocarcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Niki A. Ottenhof ◽  
Roeland F. de Wilde ◽  
Anirban Maitra ◽  
Ralph H. Hruban ◽  
G. Johan A. Offerhaus
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Treatment Strategies ◽  
Genetic Alterations ◽  
Targeted Treatment ◽  
Ductal Adenocarcinoma ◽  
Molecular Characteristics ◽  
Genetic Characteristics ◽  
Complete Sequencing ◽  
Made In

Pancreatic cancer is an almost universally lethal disease and despite extensive research over the last decades, this has not changed significantly. Nevertheless, much progress has been made in understanding the pathogenesis of pancreatic ductal adenocarcinoma (PDAC) suggesting that different therapeutic strategies based on these new insights are forthcoming. Increasing focus exists on designing the so-called targeted treatment strategies in which the genetic characteristics of a tumor guide therapy. In the past, the focus of research was on identifying the most frequently affected genes in PDAC, but with the complete sequencing of the pancreatic cancer genome the focus has shifted to defining the biological function that the altered genes play. In this paper we aimed to put the genetic alterations present in pancreatic cancer in the context of their role in signaling pathways. In addition, this paper provides an update of the recent advances made in the development of the targeted treatment approach in PDAC.

scholarly journals Tau-targeted treatment strategies in Alzheimer's disease

2012 ◽  
Vol 165 (5) ◽  
pp. 1246-1259 ◽  
Author(s):  
Jürgen Götz ◽  
Arne Ittner ◽  
Lars M Ittner
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Treatment Strategies ◽  
Targeted Treatment
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