scholarly journals miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR ‐451a/ ATF2 axis

2020 ◽  
Vol 252 (3) ◽  
pp. 239-251 ◽  
Author(s):  
Moritz A Loeffler ◽  
Jun Hu ◽  
Martina Kirchner ◽  
Xiyang Wei ◽  
Yi Xiao ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Distal Cholangiocarcinoma ◽  
Mirna Profiling ◽  
Biliary Intraepithelial Neoplasia

Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia

2008 ◽  
Vol 39 (6) ◽  
pp. 939-947 ◽  
Author(s):  
Shinichi Aishima ◽  
Yunosuke Nishihara ◽  
Eiji Tsujita ◽  
Kenichi Taguchi ◽  
Yuji Soejima ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Intraepithelial Neoplasia ◽  
Intraductal Spread ◽  
Biliary Intraepithelial Neoplasia

scholarly journals Smooth Muscle Distribution Patterns of Choledochal Cysts and Their Implications for Pathogenesis and Postoperative Complications

2020 ◽  
Vol 153 (6) ◽  
pp. 760-771
Author(s):  
Hee Sang Hwang ◽  
Mee-Jeong Kim ◽  
Seung-Soo Lee ◽  
Jae Hoon Lee ◽  
Ki Byung Song ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Biliary Stricture ◽  
Intraepithelial Neoplasia ◽  
Distribution Patterns ◽  
Postoperative Management ◽  
Clinical Implications ◽  
Type I ◽  
Choledochal Cysts ◽  
Biliary Intraepithelial Neoplasia ◽  
Chronic Irritation

Abstract Objectives Histopathologic characteristics of choledochal cysts and their clinical implications have not been previously comprehensively studied. Methods Smooth muscle distribution patterns and other histologic findings (inflammation, metaplasia, dysplasia, and heterotopia) in 233 surgically resected choledochal cysts were evaluated. Results Mean patient age was 23.3 ± 19.8 years, with male:female ratio of 0.3. Most cases were Todani type I (175 cases, 75.1%) or IVa (56 cases, 24.1%). Choledochal cysts with thin scattered/no muscle fiber (175 cases, 75.1%) were the predominant pattern and were associated with more frequent postoperative biliary stricture (P = .031), less frequent pyloric metaplasia (P = .016), and mucosal smooth muscle aggregates (P < .001) compared to cysts with thick muscle bundles. Severe chronic cholangitis (P = .049), pyloric metaplasia (P = .019), mucosal smooth muscle aggregates (P < .001), biliary intraepithelial neoplasia (P = .021), and associated bile duct (P = .021) and gallbladder carcinomas (P = .03) were more common in adults (age >20 years vs ≤20 years), suggesting that chronic irritation in association with developmental anomalies involves tumorigenesis from choledochal cysts. Conclusion Smooth muscle distribution pattern of choledochal cyst may predict postoperative complication, raising clinical implications of smooth muscle patterns in postoperative management of choledochal cysts.

Sign in / Sign up

Export Citation Format

Share Document