scholarly journals The choroid plexus stroma constitutes a sanctuary for paediatric B ‐cell precursor acute lymphoblastic leukaemia in the central nervous system

2020 ◽  
Vol 252 (2) ◽  
pp. 189-200 ◽  
Author(s):  
Lidia M Fernández‐Sevilla ◽  
Jaris Valencia ◽  
Miguel A Flores‐Villalobos ◽  
África Gonzalez‐Murillo ◽  
Rosa Sacedón ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Choroid Plexus ◽  
Lymphoblastic Leukaemia ◽  
Cell Precursor ◽  
The Central Nervous System

scholarly journals New cellular markers at diagnosis are associated with isolated central nervous system relapse in paediatric B-cell precursor acute lymphoblastic leukaemia

2015 ◽  
Vol 172 (5) ◽  
pp. 769-781 ◽  
Author(s):  
Vincent H. J. van der Velden ◽  
Daphne de Launaij ◽  
Jeltje F. de Vries ◽  
Valerie de Haas ◽  
Edwin Sonneveld ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Central Nervous System Relapse ◽  
Cell Precursor ◽  
Cellular Markers

scholarly journals Outcome of Central Nervous System Relapses In Childhood Acute Lymphoblastic Leukaemia – Prospective Open Cohort Analyses of the ALLR3 Trial

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e108107 ◽  
Author(s):  
Ashish Narayan Masurekar ◽  
Catriona A. Parker ◽  
Milensu Shanyinde ◽  
Anthony V. Moorman ◽  
Jeremy P. Hancock ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Cohort Analyses

Cerebrospinal Fluid Cytology of Lyme Neuroborreliosis: A Report of 3 Cases with Literature Review

2015 ◽  
Vol 59 (4) ◽  
pp. 339-344 ◽  
Author(s):  
Juan Xing ◽  
Lisa Radkay ◽  
Sara E. Monaco ◽  
Christine G. Roth ◽  
Liron Pantanowitz
Keyword(s):  
Central Nervous System ◽  
Flow Cytometry ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Lyme Disease ◽  
B Cell ◽  
Plasma Cells ◽  
Lyme Neuroborreliosis ◽  
Chain Analysis ◽  
The Central Nervous System

Lyme disease can affect the central nervous system causing a B-cell-predominant lymphocytic pleocytosis. Since most reactions to infection in the cerebrospinal fluid (CSF) are typically T-cell predominant, a B-cell-predominant lymphocytosis raises concern for lymphoma. We present 3 Lyme neuroborreliosis cases in order to illustrate the challenging cytomorphological and immunophenotypic features of their CSF specimens. Three male patients who presented with central nervous system manifestations were diagnosed with Lyme disease. The clinical presentation, laboratory tests, CSF cytological examination and flow-cytometric studies were described for each case. CSF cytology showed lymphocytic pleocytosis with increased plasmacytoid cells and/or plasma cells. Flow cytometry showed the presence of polytypic B lymphocytes with evidence of plasmacytic differentiation in 2 cases. In all cases, Lyme disease was confirmed by the Lyme screening test and Western blotting. In such cases of Lyme neuroborreliosis, flow cytometry of CSF samples employing plasmacytic markers and cytoplasmic light-chain analysis is diagnostically helpful to exclude lymphoma.

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