Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis

2019 ◽  
Vol 249 (1) ◽  
pp. 102-113 ◽  
Author(s):  
Juliana Y Sakita ◽  
Michael Bader ◽  
Emerson S Santos ◽  
Sergio B Garcia ◽  
Stefania B Minto ◽  
...  
Keyword(s):  
Dna Damage ◽  
Colonic Crypt ◽  
Serotonin Synthesis ◽  
Colorectal Tumorigenesis

Role of the Oxidative DNA Damage Repair Gene OGG1 in Colorectal Tumorigenesis

2013 ◽  
Vol 105 (16) ◽  
pp. 1249-1253 ◽  
Author(s):  
Christopher G. Smith ◽  
Hannah West ◽  
Rebecca Harris ◽  
Shelley Idziaszczyk ◽  
Timothy S. Maughan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Dna Damage Repair ◽  
Repair Gene ◽  
Colorectal Tumorigenesis ◽  
Damage Repair

scholarly journals Re: Role of the Oxidative DNA Damage Repair Gene OGG1 in Colorectal Tumorigenesis

2014 ◽  
Vol 106 (5) ◽  
Author(s):  
Ben Kinnersley ◽  
Stephan Buch ◽  
Sergi Castellví-Bel ◽  
Susan Mary Farrington ◽  
Asta Forsti ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Dna Damage Repair ◽  
Repair Gene ◽  
Colorectal Tumorigenesis ◽  
Damage Repair

1576: Prediction of Spermatozoal DNA Damage by a Novel Semen Quality Score

2004 ◽  
Vol 171 (4S) ◽  
pp. 416-416
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Sijo J. Parekattil ◽  
...  
Keyword(s):  
Dna Damage ◽  
Semen Quality ◽  
Quality Score

Dietary intake of tryptophan tied emotion-related impulsivity in humans

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Florian Javelle ◽  
Descartes Li ◽  
Philipp Zimmer ◽  
Sheri L. Johnson
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Food Intake ◽  
Essential Amino Acid ◽  
Food Habits ◽  
Psychological Disorder ◽  
Serotonin Synthesis ◽  
Amino Acid Tryptophan ◽  
Pass Through ◽  
Three Factor

Abstract. Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system. Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. Objective: The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Methods: Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Results: Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r =  –.502, p < . 010, and (lack-of) Follow-Through scores, r =  –.407, p < . 050. Conclusion: Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits. It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.

A safe fix for alcohol-derived DNA damage

Nature ◽  
2020 ◽  
Vol 579 (7800) ◽  
pp. 499-500
Author(s):  
Irene Gallina ◽  
Julien P. Duxin
Keyword(s):  
Dna Damage
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