scholarly journals IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer

2019 ◽  
Vol 248 (3) ◽  
pp. 377-389 ◽  
Author(s):  
Claudia Corrò ◽  
Marc E Healy ◽  
Stefanie Engler ◽  
Bernd Bodenmiller ◽  
Zhe Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Renal Cancer ◽  
Clear Cell ◽  
Cell Renal Cancer

scholarly journals Identification of a Novel Stem Cell Subtype for Clear Cell Renal Cell Carcinoma Based on Stem Cell Gene Profiling

2021 ◽  
Vol 11 ◽  
Author(s):  
Hongzhi Wang ◽  
Hanjiang Xu ◽  
Quan Cheng ◽  
Chaozhao Liang
Keyword(s):  
Renal Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Renal Cancer ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Gene Sets ◽  
Cell Gene ◽  
Stem Cell Gene

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and is characterized by high rates of metastasis. Cancer stem cell is a vital cause of renal cancer metastasis and recurrence. However, little is known regarding the change and the roles of stem cells during the development of renal cancer. To clarify this problem, we developed a novel stem cell clustering strategy. Based on The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) genomic datasets, we used 19 stem cell gene sets to classify each dataset. A machine learning method was used to perform the classification. We classified ccRCC into three subtypes—stem cell activated (SC-A), stem cell dormant (SC-D), and stem cell excluded (SC-E)—based on the expressions of stem cell-related genes. Compared with the other subtypes, C2(SC-A) had the highest degree of cancer stem cell concentration, the highest level of immune cell infiltration, a distinct mutation landscape, and the worst prognosis. Moreover, drug sensitivity analysis revealed that subgroup C2(SC-A) had the highest sensitivity to immunotherapy CTLA-4 blockade and the vascular endothelial growth factor receptor (VEGFR) inhibitor sunitinib. The identification of ccRCC subtypes based on cancer stem cell gene sets demonstrated the heterogeneity of ccRCC and provided a new strategy for its treatment.

The effect of sunitinib on immune parameters and haemopoetic stem cell markers in patients with untreated clear cell renal cancer.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 4620-4620
Author(s):  
S. Chowdhury ◽  
T. S. O’Brien ◽  
N. Sarwar ◽  
J. Shamash ◽  
S. McGrath ◽  
...  
Keyword(s):  
Stem Cell ◽  
Renal Cancer ◽  
Clear Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Immune Parameters ◽  
Cell Renal Cancer

scholarly journals Familial clear cell renal cancer

2011 ◽  
Author(s):  
A Bonné ◽  
D Bodmer ◽  
M Eleveld ◽  
EFPMG Schoenmakers ◽  
van Kessel A Geurts
Keyword(s):  
Renal Cancer ◽  
Clear Cell ◽  
Cell Renal Cancer

scholarly journals Biomarkers of Prognosis and Efficacy of Anti-angiogenic Therapy in Metastatic Clear Cell Renal Cancer

2019 ◽  
Vol 9 ◽  
Author(s):  
Carmine D'Aniello ◽  
Massimiliano Berretta ◽  
Carla Cavaliere ◽  
Sabrina Rossetti ◽  
Bianca Arianna Facchini ◽  
...  
Keyword(s):  
Renal Cancer ◽  
Clear Cell ◽  
Angiogenic Therapy ◽  
Cell Renal Cancer

Familial non-VHL non-papillary clear-cell renal cancer

The Lancet ◽  
1997 ◽  
Vol 349 (9055) ◽  
pp. 848-849 ◽  
Author(s):  
Bin Tean Teh ◽  
Sophie Giraud ◽  
Nora Fatiha Sari ◽  
Su Ing Hii ◽  
Jean Pierre Bergerat ◽  
...  
Keyword(s):  
Renal Cancer ◽  
Clear Cell ◽  
Cell Renal Cancer

scholarly journals Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e21037 ◽  
Author(s):  
Sunil Sudarshan ◽  
Karthigayan Shanmugasundaram ◽  
Susan L. Naylor ◽  
Shu Lin ◽  
Carolina B. Livi ◽  
...  
Keyword(s):  
Renal Cancer ◽  
Clear Cell ◽  
Fumarate Hydratase ◽  
Migration And Invasion ◽  
Cell Renal Cancer

Updated EAU Guidelines for Clear Cell Renal Cancer Patients Who Fail VEGF Targeted Therapy

2016 ◽  
Vol 69 (1) ◽  
pp. 4-6 ◽  
Author(s):  
Thomas Powles ◽  
Michael Staehler ◽  
Börje Ljungberg ◽  
Karim Bensalah ◽  
Steven E. Canfield ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cancer Patients ◽  
Renal Cancer ◽  
Clear Cell ◽  
Cell Renal Cancer
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