scholarly journals HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition

2017 ◽  
Vol 242 (4) ◽  
pp. 409-420 ◽  
Author(s):  
Mingang Hao ◽  
Yue Li ◽  
Jinglong Wang ◽  
Jun Qin ◽  
Yingying Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Prostate Cancer Metastasis

THE IMPACT OF DAB2IP ON EPITHELIAL-MESENCHYMAL TRANSITION (EMT) LEADING TO PROSTATE CANCER METASTASIS

2009 ◽  
Vol 181 (4S) ◽  
pp. 512-512
Author(s):  
Daxing Xie ◽  
Jun Liu ◽  
Crystal Gore ◽  
Guiyang Hao ◽  
Michael Long ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Prostate Cancer Metastasis ◽  
The Impact

scholarly journals DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis

Neoplasia ◽  
2016 ◽  
Vol 18 (9) ◽  
pp. 553-566 ◽  
Author(s):  
Eunsohl Lee ◽  
Jingcheng Wang ◽  
Kenji Yumoto ◽  
Younghun Jung ◽  
Frank C. Cackowski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Prostate Cancer Metastasis

Evidence of epithelial–mesenchymal transition in canine prostate cancer metastasis

2015 ◽  
Vol 100 ◽  
pp. 176-181 ◽  
Author(s):  
Carlos Eduardo Fonseca-Alves ◽  
Priscila Emiko Kobayashi ◽  
Luis Gabriel Rivera-Calderón ◽  
Renée Laufer-Amorim
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Prostate Cancer Metastasis

scholarly journals Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

2020 ◽  
Vol 21 (12) ◽  
pp. 4449 ◽  
Author(s):  
Timothy O. Adekoya ◽  
Ricardo M. Richardson
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Expression Patterns ◽  
Matrix Remodeling ◽  
Aberrant Expression ◽  
Mesenchymal Transition ◽  
Sequence Of Events ◽  
Prostate Cancer Metastasis ◽  
Metastatic Process

The consequences of prostate cancer metastasis remain severe, with huge impact on the mortality and overall quality of life of affected patients. Despite the convoluted interplay and cross talk between various cell types and secreted factors in the metastatic process, cytokine and chemokines, along with their receptors and signaling axis, constitute important factors that help drive the sequence of events that lead to metastasis of prostate cancer. These proteins are involved in extracellular matrix remodeling, epithelial-mesenchymal-transition, angiogenesis, tumor invasion, premetastatic niche creation, extravasation, re-establishment of tumor cells in secondary organs as well as the remodeling of the metastatic tumor microenvironment. This review presents an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis. We also provide extensive description of their aberrant expression patterns in both advanced disease states and metastatic sites, as well as their functional involvement in the various stages of the prostate cancer metastatic process.

miRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial–Mesenchymal Transition Signaling

2012 ◽  
Vol 11 (5) ◽  
pp. 1166-1173 ◽  
Author(s):  
Peng Ru ◽  
Robert Steele ◽  
Philip Newhall ◽  
Nancy J. Phillips ◽  
Karoly Toth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Prostate Cancer Metastasis

scholarly journals The SPOP-ITCH Signaling Axis Protects Against Prostate Cancer Metastasis

2021 ◽  
Vol 11 ◽  
Author(s):  
Jinlu Ma ◽  
Mengjiao Cai ◽  
Yaqi Mo ◽  
Joshua S. Fried ◽  
Xinyue Tan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Clinical Stage ◽  
Subsequent Increase ◽  
Mesenchymal Transition ◽  
Common Causes ◽  
Signaling Axis ◽  
Prostate Cancer Metastasis ◽  
Candidate Protein

Prostate cancer is one of the most common causes of cancer incidence and death in men, with the mortality caused primarily by the late-stage and metastatic forms of the disease. The mechanisms and molecular markers for prostate cancer metastasis are not fully understood. Speckle type Poz Protein (SPOP) is an E3 ubiquitin ligase adaptor that is often mutated in prostate cancer. In this study, we sequenced the SPOP gene in 198 prostate cancer patients and found 16 mutations in the cohort. Multivariate analysis revealed that SPOP mutations correlated with the clinical stage of the disease and strongly with metastasis. We identified ITCH as a candidate protein for SPOP-mediated degradation via mass spectrometry. We demonstrated the interaction between SPOP and ITCH, and found that the SPOP F133L mutation disrupted the SPOP-ITCH interaction, leading to a subsequent increase in the ITCH protein level. Further, we found that the SPOP knockdown led to higher levels of Epithelial- mesenchymal transition (EMT) proteins and increased cell invasion. Together, our results highlight the functional significance of the SPOP-ITCH pathway in prostate cancer metastasis.

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