SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis

2014 ◽  
Vol 234 (2) ◽  
pp. 178-189 ◽  
Author(s):  
Jia Li ◽  
Jim W Xuan ◽  
Vida Khatamianfar ◽  
Fatma Valiyeva ◽  
Madeleine Moussa ◽  
...  
Keyword(s):  
Centrosome Amplification ◽  
Over Expression

Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification

2007 ◽  
Vol 12 (10) ◽  
pp. 1153-1161 ◽  
Author(s):  
Noritaka Yamaguchi ◽  
Hiroyuki Koizumi ◽  
Junken Aoki ◽  
Yumiko Natori ◽  
Kiyotaka Nishikawa ◽  
...  
Keyword(s):  
Platelet Activating Factor ◽  
Centrosome Amplification ◽  
Type I ◽  
Catalytic Subunits ◽  
Over Expression ◽  
Platelet Activating Factor Acetylhydrolase

scholarly journals Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

Open Biology ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 150209 ◽  
Author(s):  
Paula A. Coelho ◽  
Leah Bury ◽  
Marta N. Shahbazi ◽  
Kifayathullah Liakath-Ali ◽  
Peri H. Tate ◽  
...  
Keyword(s):  
Primary Cilia ◽  
Primary Cultures ◽  
Centrosome Amplification ◽  
Proliferating Cells ◽  
Differentiation Markers ◽  
Over Expression ◽  
Centriole Duplication ◽  
Keratin 5 ◽  
Tumour Formation ◽  
Tumour Suppressor P53

To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4). Over-expression of Plk4 from this transgene advances the onset of tumour formation that occurs in the absence of the tumour suppressor p53. Plk4 over-expression also leads to hyperproliferation of cells in the pancreas and skin that is enhanced in a p53 null background. Pancreatic islets become enlarged following Plk4 over-expression as a result of equal expansion of α- and β-cells, which exhibit centrosome amplification. Mice overexpressing Plk4 develop grey hair due to a loss of differentiated melanocytes and bald patches of skin associated with a thickening of the epidermis. This reflects an increase in proliferating cells expressing keratin 5 in the basal epidermal layer and the expansion of these cells into suprabasal layers. Such cells also express keratin 6, a marker for hyperplasia. This is paralleled by a decreased expression of later differentiation markers, involucrin, filaggrin and loricrin. Proliferating cells showed an increase in centrosome number and a loss of primary cilia, events that were mirrored in primary cultures of keratinocytes established from these animals. We discuss how repeated duplication of centrioles appears to prevent the formation of basal bodies leading to loss of primary cilia, disruption of signalling and thereby aberrant differentiation of cells within the epidermis. The absence of p53 permits cells with increased centrosomes to continue dividing, thus setting up a neoplastic state of error prone mitoses, a prerequisite for cancer development.

1442: CXCL12 Over-Expression and Secretion by Aging Fibroblasts Stimulates Human Prostate Epithelial Proliferation in Vitro

2006 ◽  
Vol 175 (4S) ◽  
pp. 466-466
Author(s):  
Jill A. Macoska ◽  
Lesa Begley ◽  
Christine Monteleon ◽  
James W. MacDonald ◽  
Rajal B. Shah
Keyword(s):  
Human Prostate ◽  
Epithelial Proliferation ◽  
Over Expression ◽  
Proliferation In Vitro
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