A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer

2012 ◽  
Vol 228 (3) ◽  
pp. 310-321 ◽  
Author(s):  
Rong-Zong Liu ◽  
Kathryn Graham ◽  
Darryl D Glubrecht ◽  
Raymond Lai ◽  
John R Mackey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Triple Negative Breast Cancer ◽  
Fatty Acid Binding Protein ◽  
Triple Negative ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer

2010 ◽  
Vol 206 (2) ◽  
pp. 98-101 ◽  
Author(s):  
Xiao Yan Tang ◽  
Shinobu Umemura ◽  
Hideo Tsukamoto ◽  
Nobue Kumaki ◽  
Yutaka Tokuda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Differential expression of fatty acid binding protein 4 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Differential Expression ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding fatty acid binding protein 4, FABP4, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FABP4 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FABP4 in primary tumors of the breast was correlated with recurrence-free survival in patients with HER2+ cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. FABP4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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