scholarly journals The emerging role of the distal Fallopian tube and p53 in pelvic serous carcinogenesis

2010 ◽  
Vol 220 (1) ◽  
pp. 5-6 ◽  
Author(s):  
C Simon Herrington ◽  
W Glenn McCluggage
Keyword(s):  
Fallopian Tube

scholarly journals Role of superoxide dismutase in the fallopian tube function: Immunohistochemical assessment of superoxide dismutase in the fallopian tube.

1991 ◽  
Vol 24 (1) ◽  
pp. 85-91 ◽  
Author(s):  
KATSUHIKO NARIMOTO ◽  
YOICHI NODA ◽  
MASAHIDE SHIOTANI ◽  
SATOSHI NATSUYAMA ◽  
TAKAHIDE MORI ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Fallopian Tube ◽  
Tube Function ◽  
Immunohistochemical Assessment

scholarly journals The role of cytology in preoperative assessment od primary fallopian tube carcinoma: case report

2016 ◽  
Vol 52 (3) ◽  
pp. 415-420
Author(s):  
Roberta Rubeša-Mihaljević ◽  
Damjana Verša Ostojić ◽  
Morana D inter ◽  
Snježana Štemberger-Papić ◽  
Senija Eminović ◽  
...  
Keyword(s):  
Case Report ◽  
Fallopian Tube ◽  
Preoperative Assessment ◽  
Fallopian Tube Carcinoma ◽  
Primary Fallopian Tube Carcinoma

scholarly journals Culprit or Bystander? The Role of the Fallopian Tube in “Ovarian” High-Grade Serous Carcinoma

2016 ◽  
Vol 6 (12) ◽  
pp. 1309-1311 ◽  
Author(s):  
Elizabeth M. Swisher ◽  
Rochelle L. Garcia ◽  
Mark R. Kilgore ◽  
Barbara M. Norquist
Keyword(s):  
Fallopian Tube ◽  
Serous Carcinoma ◽  
High Grade

scholarly journals Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the Ovary

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 884 ◽  
Author(s):  
Matthew Dean ◽  
Vivian Jin ◽  
Tova M. Bergsten ◽  
Julia R. Austin ◽  
Daniel D. Lantvit ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Single Gene ◽  
Similar Rate ◽  
Genetic Alterations ◽  
Wild Type ◽  
Spheroid Formation ◽  
Multicellular Tumor Spheroid ◽  
Ovarian Stroma

High-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By testing a panel of murine oviductal epithelial (MOE) cells with genetic alterations mimicking those seen in HGSOC, we found that loss of PTEN allowed MTS formation under ultra-low adhesion conditions. Confirming these results in vivo, MTS-like structures were observed in the oviducts of PAX8Cre/+ PTENflox/flox mice. MOE PTENshRNA cells could incorporate up to 25% wild type cells into MTS, while higher percentages of wild type cells resulted in a loss of MTS formation. MTS formation allowed MOE PTENshRNA cells to survive better under ultra-low adhesion conditions than control cells. MTS also attached to the ovarian stroma, as would be exposed during ovulation. Interestingly, MTS more robustly cleared monolayers of murine ovarian surface epithelia than murine ovarian fibroblasts. When xenografted into the ovarian bursa, OVCAR8 MTS were able to form tumors in the ovary at a similar rate as an equal number of OVCAR8 cells grown on traditional cell culture plastic. In conclusion, loss of a single gene (PTEN) allows the fallopian tube epithelia to form MTS, which survive better under ultra-low adhesion conditions, attach to the extracellular matrix exposed during ovulation, and colonize the ovary. These results suggest that MTS may contribute to seeding of the ovary in HGSOC patients.

The Role of Prostaglandins in the Spontaneous Motility of the Fallopian Tube

1977 ◽  
Vol 28 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Murdoch George Elder ◽  
Leslie Myatt ◽  
Gautam Chaudhuri
Keyword(s):  
Fallopian Tube ◽  
Spontaneous Motility

The role of fallopian tube anastomosis in training fellows: A survey of current reproductive endocrinology fellows and practitioners

2004 ◽  
Vol 82 (2) ◽  
pp. 495-497 ◽  
Author(s):  
Alicia Armstrong ◽  
Adrienne B Neithardt ◽  
Ruben Alvero ◽  
Fady I Sharara ◽  
Mark Bush ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Reproductive Endocrinology
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