Gene amplification is a relatively frequent event leading toZBTB7A(Pokemon) overexpression in non-small cell lung cancer

2007 ◽  
Vol 213 (3) ◽  
pp. 294-302 ◽  
Author(s):  
K Apostolopoulou ◽  
IS Pateras ◽  
K Evangelou ◽  
PK Tsantoulis ◽  
M Liontos ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Amplification ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Frequent Event

O-191 HER1-HER2-HER3 gene amplification and akt activation inpatients with advanced non-small cell lung cancer (NSCLC) treated with gefitinib

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S63-S64
Author(s):  
F. Cappuzzo ◽  
M. Varella-Garcia ◽  
L. Toschi ◽  
I. Domenichini ◽  
G. Ceresoli ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Amplification ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Akt Activation

scholarly journals High MET Receptor Expression But Not Gene Amplification in ALK 2p23 Rearrangement Positive Non–Small-Cell Lung Cancer

2014 ◽  
Vol 9 (5) ◽  
pp. 646-653 ◽  
Author(s):  
Yan Feng ◽  
Eugen C. Minca ◽  
Christopher Lanigan ◽  
Angen Liu ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Amplification ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Receptor Expression ◽  
Small Cell Lung ◽  
Met Receptor

LOSS OF HETEROZYGOSITY AT 5q21 IN NON-SMALL CELL LUNG CANCER: A FREQUENT EVENT BUT WITHOUT EVIDENCE OFAPC MUTATION

1996 ◽  
Vol 180 (1) ◽  
pp. 33-37 ◽  
Author(s):  
CINDY A. COOPER ◽  
VIVIEN J. BUBB ◽  
NICOLA SMITHSON ◽  
ROBERT L. CARTER ◽  
SARAH GLEDHILL ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Loss Of Heterozygosity ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Frequent Event

scholarly journals Modern Radiation Therapy for the Management of Brain Metastases From Non-Small Cell Lung Cancer: Current Approaches and Future Directions

2021 ◽  
Vol 11 ◽  
Author(s):  
Cristina Mantovani ◽  
Alessio Gastino ◽  
Marzia Cerrato ◽  
Serena Badellino ◽  
Umberto Ricardi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Whole Brain ◽  
Clinical Scenarios ◽  
Frequent Event

Brain metastases (BMs) represent the most frequent event during the course of Non-Small Cell Lung Cancer (NSCLC) disease. Recent advancements in the diagnostic and therapeutic procedures result in increased incidence and earlier diagnosis of BMs, with an emerging need to optimize the prognosis of these patients through the adoption of tailored treatment solutions. Nowadays a personalized and multidisciplinary approach should rely on several clinical and molecular factors like patient’s performance status, extent and location of brain involvement, extracranial disease control and the presence of any “druggable” molecular target. Radiation therapy (RT), in all its focal (radiosurgery and fractionated stereotactic radiotherapy) or extended (whole brain radiotherapy) declinations, is a cornerstone of BMs management, either alone or combined with surgery and systemic therapies. Our review aims to provide an overview of the many modern RT solutions available for the treatment of BMs from NSCLC in the different clinical scenarios (single lesion, oligo and poly-metastasis, leptomeningeal carcinomatosis). This includes a detailed review of the current standard of care in each setting, with a presentation of the literature data and of the possible technical solutions to offer a “state-of-art” treatment to these patients. In addition to the validated treatment options, we will also discuss the future perspectives on emerging RT technical strategies (e.g., hippocampal avoidance whole brain RT, simultaneous integrated boost, radiosurgery for multiple lesions), and present the innovative and promising findings regarding the combination of novel targeted agents such as tyrosine kinase inhibitors and immune checkpoint inhibitors with brain irradiation.

The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer

Lung Cancer ◽  
2014 ◽  
Vol 84 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Qingquan Luo ◽  
Lili Tang ◽  
Hao Lin ◽  
Jia Huang ◽  
Tianwei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gene Amplification ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1869
Author(s):  
Laia Coll-SanMartin ◽  
Veronica Davalos ◽  
David Piñeyro ◽  
Margalida Rosselló-Tortella ◽  
Alberto Bueno-Costa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Arsenic Trioxide ◽  
Gene Amplification ◽  
Cell Lung Cancer ◽  
Cell Transformation ◽  
Mrna Translation ◽  
Small Cell ◽  
Rna Modification ◽  
Small Cell Lung

The alteration of RNA modification patterns is emerging as a common feature of human malignancies. If these changes affect key RNA molecules for mRNA translation, such as transfer RNA, they can have important consequences for cell transformation. TRIT1 is the enzyme responsible for the hypermodification of adenosine 37 in the anticodon region of human tRNAs containing serine and selenocysteine. Herein, we show that TRIT1 undergoes gene amplification-associated overexpression in cancer cell lines and primary samples of small-cell lung cancer. From growth and functional standpoints, the induced depletion of TRIT1 expression in amplified cells reduces their tumorigenic potential and downregulates the selenoprotein transcripts. We observed that TRIT1-amplified cells are sensitive to arsenic trioxide, a compound that regulates selenoproteins, whereas reduction of TRIT1 levels confers loss of sensitivity to the drug. Overall, our results indicate a role for TRIT1 as a small-cell lung cancer-relevant gene that, when undergoing gene amplification-associated activation, can be targeted with the differentiation agent arsenic trioxide.

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