Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy

2007 ◽  
Vol 213 (2) ◽  
pp. 190-199 ◽  
Author(s):  
AK Siraj ◽  
P Bavi ◽  
J Abubaker ◽  
Z Jehan ◽  
M Sultana ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Therapy ◽  
Papillary Thyroid Cancer ◽  
Expression Analysis ◽  
Middle Eastern ◽  
Papillary Thyroid ◽  
Genome Wide ◽  
Novel Target ◽  
Genome Wide Expression

scholarly journals Genome-Wide Expression Analysis of Middle Eastern Colorectal Cancer Reveals FOXM1 as a Novel Target for Cancer Therapy

2011 ◽  
Vol 178 (2) ◽  
pp. 537-547 ◽  
Author(s):  
Shahab Uddin ◽  
Maqbool Ahmed ◽  
Azhar Hussain ◽  
Jehad Abubaker ◽  
Nasser Al-Sanea ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Therapy ◽  
Expression Analysis ◽  
Middle Eastern ◽  
Genome Wide ◽  
Novel Target ◽  
Genome Wide Expression

scholarly journals Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy

2005 ◽  
Vol 115 (6) ◽  
pp. 1492-1502 ◽  
Author(s):  
Isabella T. Tai ◽  
Meiru Dai ◽  
David A. Owen ◽  
Lan Bo Chen
Keyword(s):  
Cancer Therapy ◽  
Expression Analysis ◽  
Genome Wide ◽  
Novel Target ◽  
Genome Wide Expression

Abstract 730: Annual hazard rate of recurrence in Middle-Eastern papillary thyroid cancer over a long-term follow-up

2021 ◽  
Author(s):  
Abdul K. Siraj ◽  
Sandeep K. Parvathareddy ◽  
Zeeshan Qadri ◽  
Saud Azam ◽  
Felisa De Vera ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Hazard Rate ◽  
Middle Eastern ◽  
Papillary Thyroid ◽  
Long Term Follow Up

Epigenetic Alterations and Canonical Pathway Disruption in Papillary Thyroid Cancer: A Genome-wide Methylation Analysis

2016 ◽  
Vol 23 (7) ◽  
pp. 2302-2309 ◽  
Author(s):  
Michael G. White ◽  
Sapna Nagar ◽  
Briseis Aschebrook-Kilfoy ◽  
Farzana Jasmine ◽  
Muhammad G. Kibriya ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Canonical Pathway ◽  
Epigenetic Alterations ◽  
Papillary Thyroid ◽  
Methylation Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals Annual Hazard Rate of Recurrence in Middle Eastern Papillary Thyroid Cancer over a Long-Term Follow-Up

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3624
Author(s):  
Abdul K. Siraj ◽  
Sandeep Kumar Parvathareddy ◽  
Zeeshan Qadri ◽  
Khawar Siddiqui ◽  
Saif S. Al-Sobhi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Hazard Rate ◽  
Tumor Recurrence ◽  
Cox Regression ◽  
Middle Eastern ◽  
Treatment Strategies ◽  
Recurrence Risk ◽  
Papillary Thyroid ◽  
Cox Regression Analysis

Predicting the pattern of recurrence in papillary thyroid cancer (PTC) is necessary to establish optimal surveillance and treatment strategies. We analyzed changes in hazard rate (HR) for tumor recurrence over time in 1201 unselected Middle Eastern PTC patients. The changes in risk were further analyzed according to clinical variables predictive of early (≤5 years) and late (>5 years) recurrence using Cox regression analysis to identify patient populations that remain at risk. Tumor recurrence was noted in 18.4% (221/1201) patients. The annualized hazard of PTC recurrence was highest during the first 5 years (2.8%), peaking between 1 and 2 years (3.7%), with a second smaller peak between 13 and 14 years (3.2%). Patients receiving radioactive iodine (RAI) therapy had lower recurrence hazard compared to those who did not (1.5% vs. 2.7%, p = 0.0001). Importantly, this difference was significant even in intermediate-risk PTC patients (0.7% vs. 2.3%; p = 0.0001). Interestingly, patients aged ≥55 years and having lymph node metastasis were at persistent risk for late recurrence. In conclusion, we confirmed the validity of the double-peaked time-varying pattern for recurrence risk in Middle Eastern PTC patients and our findings could help in formulating individualized treatment and surveillance plans.

scholarly journals Genome-wide alterations in gene methylation by the BRAF V600E mutation in papillary thyroid cancer cells

2011 ◽  
Vol 18 (6) ◽  
pp. 687-697 ◽  
Author(s):  
Peng Hou ◽  
Dingxie Liu ◽  
Mingzhao Xing
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Papillary Thyroid Cancer ◽  
Cpg Island ◽  
Epigenetic Mechanism ◽  
Papillary Thyroid ◽  
Cellular Functions ◽  
Gene Methylation ◽  
Genome Wide ◽  
Thyroid Cancer Cells

The BRAF V600E mutation plays an important role in the tumorigenesis of papillary thyroid cancer (PTC). To explore an epigenetic mechanism involved in this process, we performed a genome-wide DNA methylation analysis using a methylated CpG island amplification (MCA)/CpG island microarray system to examine gene methylation alterations after shRNA knockdown of BRAF V600E in thyroid cancer cells. Our results revealed numerous methylation targets of BRAF V600E mutation with a large cohort of hyper- or hypo-methylated genes in thyroid cancer cells, which are known to have important metabolic and cellular functions. As hypomethylation of numerous genes by BRAF V600E was particularly a striking finding, we took a further step to examine the selected 59 genes that became hypermethylated in both cell lines upon BRAF V600E knockdown and found them to be mostly correspondingly under-expressed (i.e. they were normally maintained hypomethylated and over-expressed by BRAF V600E in thyroid cancer cells). We confirmed the methylation status of selected genes revealed on MCA/CpG microarray analysis by performing methylation-specific PCR. To provide proof of concept that some of the genes uncovered here may play a direct oncogenic role, we selected six of them to perform shRNA knockdown and examined its effect on cellular functions. Our results demonstrated that the HMGB2 gene played a role in PTC cell proliferation and the FDG1 gene in cell invasion. Thus, this study uncovered a prominent epigenetic mechanism through which BRAF V600E can promote PTC tumorigenesis by altering the methylation and hence the expression of numerous important genes.

scholarly journals Genome-Wide Methylation Patterns in Papillary Thyroid Cancer Are Distinct Based on Histological Subtype and Tumor Genotype

2014 ◽  
Vol 99 (2) ◽  
pp. E329-E337 ◽  
Author(s):  
Ryan J. Ellis ◽  
Yonghong Wang ◽  
Holly S. Stevenson ◽  
Myriem Boufraqech ◽  
Dhaval Patel ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Histological Subtype ◽  
Papillary Thyroid ◽  
Genome Wide ◽  
Methylation Patterns
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