Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissuein vivo and in bone marrow culturesin vitro: implications for the assessment of lymphangiogenesis

2006 ◽  
Vol 209 (1) ◽  
pp. 67-77 ◽  
Author(s):  
K Schledzewski ◽  
M Falkowski ◽  
G Moldenhauer ◽  
P Metharom ◽  
J Kzhyshkowska ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Lymphatic Endothelium ◽  
Malignant Tumours ◽  
Hyaluronan Receptor

Determinants of wound healing in bone marrow-impregnated collagen matrix treatment: Impact of microcirculatory response to surgical debridement

2009 ◽  
Vol 17 (4) ◽  
pp. 492-497 ◽  
Author(s):  
Shigeru Ichioka ◽  
Hideki Yokogawa ◽  
Naomi Sekiya ◽  
Sachio Kouraba ◽  
Ai Minamimura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Collagen Matrix ◽  
Surgical Debridement

scholarly journals Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

2021 ◽  
Vol 22 (6) ◽  
pp. 3055
Author(s):  
Fahad S. M. Alshehri ◽  
Claire S. Whyte ◽  
Nicola J. Mutch
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Crucial Role ◽  
Factor Xiii ◽  
Severe Bleeding ◽  
Bleeding Diathesis ◽  
Unknown Mechanism ◽  
Protein Substrates ◽  
Physiological Processes ◽  
Isopeptide Bonds

Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε-(γ-glutamyl)lysyl isopeptide bonds into protein substrates. The plasma form, FXIIIA2B2, has an established function in haemostasis, with fibrin being its principal substrate. A deficiency in FXIII manifests as a severe bleeding diathesis emphasising its crucial role in this pathway. The FXIII-A gene (F13A1) is expressed in cells of bone marrow and mesenchymal lineage. The cellular form, a homodimer of the A subunits denoted FXIII-A, was perceived to remain intracellular, due to the lack of a classical signal peptide for its release. It is now apparent that FXIII-A can be externalised from cells, by an as yet unknown mechanism. Thus, three pools of FXIII-A exist within the circulation: plasma where it circulates in complex with the inhibitory FXIII-B subunits, and the cellular form encased within platelets and monocytes/macrophages. The abundance of this transglutaminase in different forms and locations in the vasculature reflect the complex and crucial roles of this enzyme in physiological processes. Herein, we examine the significance of these pools of FXIII-A in different settings and the evidence to date to support their function in haemostasis and wound healing.

scholarly journals Correction: Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145565 ◽  
Author(s):  
Lei Chen ◽  
Yingbin Xu ◽  
Jingling Zhao ◽  
Zhaoqiang Zhang ◽  
Ronghua Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Conditioned Medium

Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

2021 ◽  
pp. 153473462110290
Author(s):  
Nazira Fatima ◽  
Muhammad Saleem
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Sodium Nitroprusside ◽  
Bone Marrow Cells ◽  
Healing Process ◽  
Wound Healing Process ◽  
Inflammatory Infiltration ◽  
Acute Wound ◽  
High Concentrations ◽  
Marrow Cells

The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.

scholarly journals The Role of a Combination of Autogenous Fresh Bone Marrow and Omental Free Graft in the Cervical Esophageal Wound Healing in Dogs

2010 ◽  
Vol 5 (3) ◽  
pp. 202-207
Author(s):  
Omid Azari ◽  
Mohammad Mahdi Molaei ◽  
Reza Kheirandis ◽  
Sara Hamzeh Aliabad
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Free Graft ◽  
Fresh Bone

Improved wound healing of postischemic cutaneous flaps with the use of bone marrow-derived stem cells

2013 ◽  
Vol 124 (3) ◽  
pp. 642-648 ◽  
Author(s):  
Melissa Hu ◽  
David Ludlow ◽  
J. Steven Alexander ◽  
Jerry McLarty ◽  
Timothy Lian
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing

In vivo systemic delivery of bone marrow-derived mesenchymal stromal cells results in enhanced fascial wound healing

2006 ◽  
Vol 203 (3) ◽  
pp. S42
Author(s):  
David S. Kwon ◽  
Tina Gao ◽  
Bo Liu ◽  
Deborah Dulchavsky ◽  
Scott Dulchavsky ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Systemic Delivery
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