Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice by oral immune regulation towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels

2005 ◽  
Vol 208 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Eran Elinav ◽  
Orit Pappo ◽  
Miriam Sklair-Levy ◽  
Maya Margalit ◽  
Oren Shibolet ◽  
...  
Keyword(s):  
Glucose Intolerance ◽  
Immune Regulation ◽  
Alcoholic Steatohepatitis ◽  
Nkt Lymphocytes

scholarly journals Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 959
Author(s):  
Victor Sánchez ◽  
Annette Brandt ◽  
Cheng Jun Jin ◽  
Dragana Rajcic ◽  
Anna Janina Engstler ◽  
...  
Keyword(s):  
Soybean Oil ◽  
Mrna Expression ◽  
Glucose Intolerance ◽  
Barrier Function ◽  
Control Diet ◽  
Saturated Fatty Acids ◽  
Interleukin 1 ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Alcoholic Steatohepatitis

The addition of plant oils such as soybean oil (S) to a diet rich in saturated fatty acids is discussed as a possible route to prevent or diminish the development of metabolic disease. Here, we assessed whether a butterfat-rich diet fortified with S affects the development of early non-alcoholic steatohepatitis (NASH) and glucose intolerance. Female C57BL/6J mice were fed a standard-control diet (C); a fat-, fructose-, and cholesterol-rich diet (FFC, 25E% butterfat, 50% (wt./wt.) fructose, 0.16% (wt./wt.) cholesterol); or FFC supplemented with S (FFC + S, 21E% butterfat + 4E% S) for 13 weeks. Indicators of liver damage, inflammation, intestinal barrier function, and glucose metabolism were measured. Lipopolysaccharide (LPS)-challenged J774A.1 cells were incubated with linolenic and linoleic acids (ratio 1:7.1, equivalent to S). The development of early NASH and glucose intolerance was significantly attenuated in FFC + S–fed mice compared to FFC-fed mice associated with lower hepatic toll-like receptor-4 mRNA expression, while markers of intestinal barrier function were significantly higher than in C-fed mice. Linolenic and linoleic acid significantly attenuated LPS-induced formation of reactive nitrogen species and interleukin-1 beta mRNA expression in J774A.1 cells. Our results indicate that fortifying butterfat with S may attenuate the development of NASH and glucose intolerance in mice.

692 Adoptive transfer of regulatory NKT lymphocytes ameliorates steatohepatitis and glucose intolerance in leptin-deficient mice

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 493-493
Author(s):  
E ELINAV ◽  
O PAPPO ◽  
M SKLAIRLEVY ◽  
M GOMORI ◽  
O SHIBOLET ◽  
...  
Keyword(s):  
Glucose Intolerance ◽  
Adoptive Transfer ◽  
Deficient Mice ◽  
Nkt Lymphocytes

Non-alcoholic steatohepatitis sensitizes to TLR9-induced liver injury

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
T Csak ◽  
A Dolganiuc ◽  
B Nath ◽  
J Patrasek ◽  
K Kodys ◽  
...  
Keyword(s):  
Liver Injury ◽  
Alcoholic Steatohepatitis
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