ILK over-expression in human colon cancer progression correlates with activation of β-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway

2005 ◽  
Vol 208 (1) ◽  
pp. 91-99 ◽  
Author(s):  
V Bravou ◽  
G Klironomos ◽  
E Papadaki ◽  
S Taraviras ◽  
J Varakis
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Human Colon ◽  
Down Regulation ◽  
Human Colon Cancer ◽  
Over Expression ◽  
Colon Cancer Progression ◽  
E Cadherin

scholarly journals Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression

Cell Cycle ◽  
2009 ◽  
Vol 8 (3) ◽  
pp. 473-481 ◽  
Author(s):  
Sabina Pucci ◽  
Paola Mazzarelli ◽  
Fabiola Sesti ◽  
David A. Boothman ◽  
Luigi G. Spagnoli
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Progression ◽  
Interleukin 6 ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Progression

Is acetylcholine a signaling molecule for human colon cancer progression?

2011 ◽  
Vol 46 (4) ◽  
pp. 446-455 ◽  
Author(s):  
Ann Novotny ◽  
Kristin Ryberg ◽  
Jenny Heiman Ullmark ◽  
Linn Nilsson ◽  
Amir Khorram-Manesh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Signaling Molecule ◽  
Colon Cancer Progression

scholarly journals LINC02418 promotes colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jun Tian ◽  
Peng Cui ◽  
Yifei Li ◽  
Xuequan Yao ◽  
Xiaoyu Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Kaplan Meier ◽  
Lovo Cells ◽  
Colon Cancer Progression ◽  
Prediction Of Prognosis

Abstract Background LncRNAs act as functional regulators in tumor progression through interacting with various signaling pathways in multiple types of cancer. However, the effect of LINC02418 on colorectal cancer (CRC) progression and the underling mechanisms remain unclear. Methods LncRNA expression profile in CRC tissues was investigated by the TCGA database. The expressional level of LINC02418 in CRC patients was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Kaplan–Meier analyses was used to investigate the correlation between LINC02418 and overall survival (OS) of CRC patients. Cell proliferative, migratory and invasive abilities were detected by CCK-8 assays, colony formation assays and trans-well assays in HCT116 and LoVo cells which were stably transduced with sh-LINC02418 or sh-NC. The binding between LINC02418 and miR-34b-5p, and the interaction between miR-34b-5p and BCL2 were determined by dual-luciferase assays. Western blot experiments were conducted to further explore the effect of miR-34b-5p on BCL2 signaling pathway. Rescue experiments were performed to uncover the role of LINC02418/miR-34b-5p/BCL2 axis in CRC progression. Results LINC02418 was upregulated in human colon cancer samples when compared with adjacent tissue, and its high expressional level correlated with poor prognosis of CRC patients. LINC02418 promoted cancer progression by enhancing tumor growth, cell mobility and invasiveness of colon cancer cells. Additionally, LINC02418 could physically bind to miR-34b-5p and subsequently affect BCL2 signaling pathway. Down-regulation of LINC02418 reduced cell proliferation, while transfection of miR-34b-5p inhibitor or BCL2 into LINC02418-silenced CRC cells significantly promoted CRC cells growth. Conclusions LINC02418 was upregulated in human CRC samples and could be used as the indicator for prediction of prognosis. LINC02418 acted as a tumor driver by negatively regulating cell apoptosis through LINC02418/miR-34b-5p/BCL2 axis in CRC.

scholarly journals Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival

Oncoscience ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 131-141 ◽  
Author(s):  
Esther Martínez-Martínez ◽  
Irene Gómez ◽  
Paloma Martín ◽  
Antonio Sánchez ◽  
Laura Román ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Patient Survival ◽  
Human Colon ◽  
Receptor Type ◽  
Human Colon Cancer ◽  
Colon Cancer Progression

scholarly journals LINC02418 promotes colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis

2020 ◽  
Author(s):  
Jun Tian ◽  
Peng Cui ◽  
Yifei Li ◽  
Xuequan Yao ◽  
Xiaoyu Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Kaplan Meier ◽  
Lovo Cells ◽  
Colon Cancer Progression ◽  
Prediction Of Prognosis

Abstract Background LncRNAs act as functional regulators in tumor progression through interacting with various signaling pathways in multiple types of cancer. However, the effect of LINC02418 on colorectal cancer (CRC) progression and the underling mechanisms remain unclear.Methods LncRNA expression profile in CRC tissues was investigated by the TCGA database. The expressional level of LINC02418 in CRC patients was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Kaplan-Meier analyses was used to investigate the correlation between LINC02418 and overall survival (OS) of CRC patients. Cell proliferative, migratory and invasive abilities were detected by CCK-8 assays, colony formation assays and trans-well assays in HCT116 and LoVo cells which were stably transduced with sh-LINC02418 or sh-NC. The binding between LINC02418 and miR-34b-5p, and the interaction between miR-34b-5p and BCL2 were determined by dual-luciferase assays. Western blot experiments were conducted to further explore the effect of miR-34b-5p on BCL2 signaling pathway. Rescue experiments were performed to uncover the role of LINC02418 /miR-34b-5p/ BCL2 axis in CRC progression.Results LINC02418 was upregulated in human colon cancer samples when compared with adjacent tissue, and its high expressional level correlated with poor prognosis of CRC patients. LINC02418 promoted cancer progression by enhancing tumor growth, cell mobility and invasiveness of colon cancer cells. Additionally, LINC02418 could physically bind to miR-34b-5p and subsequently affect BCL2 signaling pathway. Down-regulation of LINC02418 reduced cell proliferation, while transfection of miR-34b-5p inhibitor or BCL2 into LINC02418-silenced CRC cells significantly promoted CRC cells growth.Conclusions LINC02418 was upregulated in human CRC samples and could be used as the indicator for prediction of prognosis. LINC02418 acted as a tumor driver by negatively regulating cell apoptosis through LINC02418 /miR-34b-5p/ BCL2 axis in CRC.

scholarly journals Cdx1 homeobox gene during human colon cancer progression

Oncogene ◽  
2003 ◽  
Vol 22 (39) ◽  
pp. 7913-7921 ◽  
Author(s):  
Claire Domon-Dell ◽  
Anne Schneider ◽  
Virginie Moucadel ◽  
Eric Guerin ◽  
Dominique Guenot ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Homeobox Gene ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Progression

scholarly journals The Critical Role of Dysregulated FOXM1–PLAUR Signaling in Human Colon Cancer Progression and Metastasis

2012 ◽  
Vol 19 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Dawei Li ◽  
Ping Wei ◽  
Zhihai Peng ◽  
Chen Huang ◽  
Huamei Tang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Critical Role ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Colon Cancer Progression
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