Protective role of heat shock protein 27 in gastric mucosal injury

2005 ◽  
Vol 207 (2) ◽  
pp. 177-184 ◽  
Author(s):  
Matthias PA Ebert ◽  
Claus Schäfer ◽  
Jie Chen ◽  
Juliane Hoffmann ◽  
Ping Gu ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Mucosal Injury ◽  
Protective Role ◽  
Heat Shock Protein 27 ◽  
Gastric Mucosal Injury

Protective role of myocardial heat shock protein 70 in burn trauma: Another brick in the wall?

2004 ◽  
Vol 32 (6) ◽  
pp. 1425-1426 ◽  
Author(s):  
Martin Westphal ◽  
Perenlei Enkhbaatar ◽  
Daniel L. Traber
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Role ◽  
Burn Trauma

Role of Heat Shock Protein 27 in Regulation of Glutathione System and Apoptosis of Jurkat Tumor Cells and Blood Lymphocytes

2015 ◽  
Vol 158 (3) ◽  
pp. 377-379 ◽  
Author(s):  
N. V. Ryazantseva ◽  
E. A. Stepovaya ◽  
O. L. Nosareva ◽  
E. V. Konovalova ◽  
D. S. Orlov ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Heat Shock Protein 27 ◽  
Glutathione System ◽  
Blood Lymphocytes

scholarly journals Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment ?

2019 ◽  
Author(s):  
Seul-Ki Choi ◽  
Heejin Kam ◽  
Kye-Young Kim ◽  
Suk In Park ◽  
Yun-Sil Lee
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Treatment ◽  
Poor Prognosis ◽  
Treatment Resistance ◽  
Therapeutic Agents ◽  
Heat Shock Protein 27 ◽  
Cytoskeletal Remodeling ◽  
Protein Chaperone

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-dimensional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a major role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with poor prognosis, as well as treatment resistance whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as strategies for using HSP27 inhibitors for therapeutic purposes.

scholarly journals Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.

1996 ◽  
Vol 10 (11) ◽  
pp. 1371-1378 ◽  
Author(s):  
W Porter ◽  
F Wang ◽  
W Wang ◽  
R Duan ◽  
S Safe
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27

The Role of heat shock protein 27 in extravillous trophoblast differentiation

2008 ◽  
Vol 103 (3) ◽  
pp. 719-729 ◽  
Author(s):  
S. Tartakover Matalon ◽  
L. Drucker ◽  
A. Fishman ◽  
A. Ornoy ◽  
M. Lishner
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Extravillous Trophoblast ◽  
Trophoblast Differentiation

Protective role of Mycobacterium leprae small heat-shock protein in heterologous hosts, Escherichia coli and Mycobacterium smegmatis, grown under stress

2013 ◽  
Vol 62 (7) ◽  
pp. 959-967 ◽  
Author(s):  
Jayapal Jeya Maheshwari ◽  
Kuppamuthu Dharmalingam
Keyword(s):  
Escherichia Coli ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Mycobacterium Smegmatis ◽  
Small Heat Shock Protein ◽  
Mycobacterium Leprae ◽  
Protective Role ◽  
Low Oxygen

The aim of this study is to examine the in vivo role of a small heat-shock protein (sHsp18) from Mycobacterium leprae in the survival of heterologous recombinant hosts carrying the gene encoding this protein under different environmental conditions that are normally encountered by M. leprae during its infection of the human host. Using an Escherichia coli system where shsp18 expression is controlled by its native promoter, we show that expression of shsp18 is induced under low oxygen tension, nutrient depletion and oxidative stress, all of which reflect the natural internal environment of the granulomas where the pathogen resides for long periods. We demonstrate the in vivo chaperone activity of sHsp18 through its ability to confer survival advantage to recombinant E. coli at heat-shock temperatures. Additional evidence for the protective role of sHsp18 was obtained when Mycobacterium smegmatis harbouring a copy of shsp18 was found to multiply better in human macrophages. Furthermore, the autokinase activity of sHsp18 protein demonstrated for what is believed to be the first time in this study implies that some of the functions of sHsp18 might be controlled by the phosphorylation state of this protein. Results from this study suggest that shsp18 might be one of the factors that facilitate the survival and persistence of M. leprae under stress and autophosphorylation of sHsp18 protein could be a mechanism used by this protein to sense changes in the external environment.

Protective Role of Genetic Polymorphism of Heat Shock Protein 70-2 for Gastric Cancer Risk

2008 ◽  
Vol 54 (1) ◽  
pp. 70-74 ◽  
Author(s):  
Tomoyuki Shibata ◽  
Tomiyasu Arisawa ◽  
Tomomitsu Tahara ◽  
Daisuke Yoshioka ◽  
Naoko Maruyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Polymorphism ◽  
Heat Shock ◽  
Cancer Risk ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Role ◽  
Gastric Cancer Risk
Sign in / Sign up

Export Citation Format

Share Document