The value of mitotic counting in the assessment of prognosis and proliferation in human tumours

1991 ◽  
Vol 163 (4) ◽  
pp. 361-364 ◽  
Author(s):  
Yrjö Collan ◽  
Hannu Haapasalo ◽  
Cecily M. Quinn ◽  
Nicholas A. Wright
Keyword(s):  
Human Tumours ◽  
Mitotic Counting

Co-purification of bone resorbing activity and adenylate cyclase stimulating activity from human tumours associated with the humoral hypercalcaemia of malignancy

1987 ◽  
Vol 114 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Chohei Shigeno ◽  
Itsuo Yamamoto ◽  
Shegiharu Dokoh ◽  
Megumu Hino ◽  
Jun Aoki ◽  
...  
Keyword(s):  
Bone Resorption ◽  
High Performance ◽  
Basic Protein ◽  
Gel Filtration ◽  
Exchange Chromatography ◽  
Protein Factor ◽  
Human Tumours ◽  
Acid Stable ◽  
Bone Resorbing Activity

Abstract. We have partially purified a tumour factor capable of stimulating both bone resorption in vitro and cAMP accumulation in osteoblastic ROS 17/2 cells from three human tumours associated with humoral hypercalcaemia of malignancy. Purification of tumour factor by sequential acid urea extraction, gel filtration and cation-exchange chromatography, reverse-phase high performance liquid chromatography followed by analytical isoelectric focussing provided a basic protein (pI > 9.3) with a molecular weight of approximately 13 000 as a major component of the final preparation which retained both the two bioactivities. Bone resorbing activity and cAMP-increasing activity in purified factor correlated with each other. cAMP-increasing activity of the factor was heat- and acid-stable, but sensitive to alkaline ambient pH. Treatment with trypsin destroyed cAMP-increasing activity of the factor. Synthetic parathyroid hormone (PTH) antagonist, human PTH-(3– 34) completely inhibited the cAMP-increasing activity of the factor. The results suggest that this protein factor, having its effects on both osteoclastic and osteoblastic functions, may be involved in development of enhanced bone resorption in some patients with humoral hypercalcaemia of malignancy.

scholarly journals Targeting Transforming Growth Factor β to Enhance Cancer Immunotherapy

2006 ◽  
Vol 13 (4) ◽  
pp. 141-143 ◽  
Author(s):  
T. Hahn ◽  
Emmanuel Akporiaye
Keyword(s):  
Immune System ◽  
Growth Factor ◽  
Cancer Immunotherapy ◽  
Immune Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Human Tumours

Human tumours have evolved intricate mechanisms to evade the immune system, either by avoiding recognition or by inhibiting and eliminating immune cells. [...]

Cell proliferation in human tumours measured byin-vivolabelling with bromodeoxyuridine

1988 ◽  
Vol 61 (725) ◽  
pp. 419-422 ◽  
Author(s):  
G. D. Wilson ◽  
N. J. McNally ◽  
S. Dische ◽  
M. H. Bennett
Keyword(s):  
Cell Proliferation ◽  
Human Tumours

Effect of Colchicine on Human Tumours transplanted in Cheek Pouch of Syrian Hamster

Nature ◽  
1964 ◽  
Vol 203 (4940) ◽  
pp. 90-92 ◽  
Author(s):  
GIUSEPPE CARDINALI ◽  
GIULIANA CARDINALI ◽  
ALFRED H. HANDLER
Keyword(s):  
Syrian Hamster ◽  
Cheek Pouch ◽  
Human Tumours

The biological significance of lymphangiogenesis in human tumours

2010 ◽  
Vol 16 (6) ◽  
pp. 295-305 ◽  
Author(s):  
Daniela Massi ◽  
Özay Gököz
Keyword(s):  
Biological Significance ◽  
Human Tumours

Relevance of chromosome 13 aberrations in canine tumours

2012 ◽  
Vol 40 (04) ◽  
pp. 267-270 ◽  
Author(s):  
H. Escobar ◽  
I. Nolte ◽  
N. Reimann-Berg
Keyword(s):  
Chromosome Aberrations ◽  
Human Chromosomes ◽  
High Homology ◽  
Chromosome 13 ◽  
Human Tumours ◽  
Cytogenetic Studies ◽  
Canine Chromosome ◽  
Chromosomal Changes

SummaryFor human tumours there are many reports documenting the correlation between chromosome aberrations and tumour entities. Due to the complex canine karyotypic pattern (78 chromosomes), cytogenetic studies of tumours of the dog are rare. However, the reports in the literature show, that canine chromosome 13 (CFA 13) is predominantly involved in chromosomal changes. Interestingly, CFA 13 shows high homology to regions on the human chromosomes 4 (HSA 4) and 8 (HSA 8), which harbour the proto-oncogenes c-KIT and c-MYC. Both of these genes are involved in the development and progression of some human and canine tumour diseases.

The expression profile of alternatively spliced neuronalc-src RNA distinguishes between human tumours of the sympatho-adrenal lineage

1995 ◽  
Vol 60 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Eva Örtoft ◽  
Catarina Bjelfman ◽  
Fredrik Hedborg ◽  
Lars Grimelius ◽  
Svcn Påhlman
Keyword(s):  
Expression Profile ◽  
Human Tumours ◽  
Alternatively Spliced

Angiogenic Polypeptides in Breast Cancer: Expression of Mrna’s in Primary Human Tumours, MCF-7 Cell Transfection and Xenograft Models

Angiogenesis ◽  
1998 ◽  
pp. 213-221
Author(s):  
Hua-Tang Zhang ◽  
Rangana Choudhuri ◽  
Prudence AE Scott ◽  
Lyna Zhang ◽  
Marina Ziche ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Transfection ◽  
Human Tumours ◽  
Xenograft Models ◽  
Mcf 7

TESTING CHEMOSENSITIVITY OF HUMAN TUMOURS

The Lancet ◽  
1983 ◽  
Vol 321 (8316) ◽  
pp. 134 ◽  
Author(s):  
Jürgen Mattern
Keyword(s):  
Human Tumours
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