Sarcomatoid tumours of lymph nodes showing follicular dendritic cell differentiation

1991 ◽  
Vol 163 (3) ◽  
pp. 205-216 ◽  
Author(s):  
Kevin Hollowood ◽  
Christopher Pease ◽  
Alasdair M. Mackay ◽  
Christopher D. M. Fletcher
Keyword(s):  
Cell Differentiation ◽  
Dendritic Cell ◽  
Lymph Nodes ◽  
Follicular Dendritic Cell ◽  
Dendritic Cell Differentiation ◽  
Follicular Dendritic

scholarly journals Repeated Antigen Challenge Modulates Expression of Follicular Dendritic Cell (FDC) Related Molecule in Draining Lymph Nodes.

2001 ◽  
Vol 34 (4) ◽  
pp. 265-273 ◽  
Author(s):  
Yoshiaki Ohmori ◽  
Toshiko Yoshida ◽  
Motonori Okabe ◽  
Kenichi Takaya ◽  
Fumitomo Koizumi ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lymph Nodes ◽  
Follicular Dendritic Cell ◽  
Antigen Challenge ◽  
Related Molecule ◽  
Follicular Dendritic ◽  
Draining Lymph Nodes

scholarly journals Establishment of Lymphotoxin β Receptor Signaling-Dependent Cell Lines with Follicular Dendritic Cell Phenotypes from Mouse Lymph Nodes

2006 ◽  
Vol 177 (8) ◽  
pp. 5204-5214 ◽  
Author(s):  
Yumiko Nishikawa ◽  
Masaki Hikida ◽  
Masaki Magari ◽  
Naoki Kanayama ◽  
Masaharu Mori ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lymph Nodes ◽  
Cell Lines ◽  
Follicular Dendritic Cell ◽  
Receptor Signaling ◽  
Dependent Cell ◽  
Follicular Dendritic ◽  
Β Receptor ◽  
Cell Phenotypes

Follicular dendritic cell sarcoma arising from the hypopharynx

2004 ◽  
Vol 118 (4) ◽  
pp. 317-318 ◽  
Author(s):  
Christos Georgalas ◽  
Jeeve Kanagalingam ◽  
Andrew Gallimore ◽  
Paul O’Flynn
Keyword(s):  
Dendritic Cell ◽  
Lymph Nodes ◽  
Follicular Dendritic Cell ◽  
Malignant Tumours ◽  
Dendritic Cell Sarcoma ◽  
First Case ◽  
Accessory Cells ◽  
Rare Tumours ◽  
Node Metastases ◽  
Follicular Dendritic

Follicular dendritic cell (FDC) tumours have been described recently as malignant tumours arising from accessory cells of the lymph nodes. They are rare tumours with fewer than 70 cases occurring worldwide. They usually present in cervical or abdominal lymph nodes,with very few occurring extranodally. We present the first case of an FDC tumour to occur in the hypopharynx with simultaneous cervical node metastases. The pathology is discussed and the literature reviewed.

scholarly journals POS0782 FOLLICULAR DENDRITIC CELL NETWORKS IN MINOR SALIVARY GLAND BIOPSIES: A MARKER OF DISEASE ACTIVITY AT BASELINE AND DURING THE FOLLOW-UP IN SJÖGREN’S SYNDROME

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 644.2-644
Author(s):  
C. Baldini ◽  
F. Ferro ◽  
G. Fulvio ◽  
G. La Rocca ◽  
S. Fonzetti ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Dendritic Cell ◽  
Disease Activity ◽  
Inflammatory Infiltrate ◽  
Minor Salivary Gland ◽  
Sjogren’S Syndrome ◽  
Follicular Dendritic Cell ◽  
Sjogren's Syndrome ◽  
Follicular Dendritic

Background:Minor salivary gland biopsy (MSGB) has been increasingly recognized as an important tool for the stratification of patients with primary Sjögren’s syndrome (pSS). Recently, the presence of follicular dendritic cell (FDC) networks in the inflammatory infiltrate has been associated with more severe biological and serological abnormalities compared with less organized infiltrates.Objectives:To investigate the associations between the presence and number of FDC networks in foci and pSS glandular and extra-glandular disease activity at baseline and during the follow-up.Methods:Consecutive MSGBs performed in daily practice for clinically suspected pSS from January 2017 to October 2020 were reviewed. Patients’ demographic, clinical, biological and serological data were obtained from medical records. The ESSDAI was used to measure disease activity at baseline and at the end of the follow-up in pSS patients. For histopathology, 3 µm sections were cut from each formalin-fixed paraffin-embedded block of MSGBs and stained with haematoxylin and eosin (H&E). Immunohistochemical stainings were performed on additional 3 μm sections in order to detect T lymphocytes (CD3), B lymphocytes (CD20) and follicular dendritic cells (CD21). Glandular tissue areas, number of foci, focus score (FS) and the presence and number of FDC networks were assessed.Results:We reviewed 330 consecutive MSGBs from patients with suspected pSS: out of them 146/330 (44%) were classified as nonspecific chronic sialadenitis (NSCS) whereas 184/330 (56%) as focal lymphocytic sialadenitis (FLS). According to the ACR/EULAR criteria the diagnosis of pSS was confirmed in 130 patients (117 F:13 M, age 56±13 yrs). The mean (S.D) surface area of the MSGBs was 7.8 (3.9) mm2. The number of foci in the FLS samples ranged from 1 to 12 (mean (S.D)=3.1 (2.6)), whereas the FS ranged from 0.3 to 9.0 (mean (S.D) = 1.4 (1.2)).The presence of FDC networks was documented in 106/330 (32%) of the samples; in 54/106 (51%) of these MSGBs the number of FDC networks ranged from 2 to 8 (mean (S.D)=3.1 (1.4)). The number of FDC networks significantly correlated with the number of foci (r=0.721**) and FS (r=0.707**). Patients with FDC networks in the inflammatory infiltrate presented more serological abnormalities (i.e anti-Ro/SSA, anti-LA/SSB, Rheumatoid factor) and elevated IgG levels (p<0.001). In pSS patients, the number of FDC networks slightly correlated also with C4 levels (r=-0.216*), peripheral lymphocyte count (r=-0.274**) and with glandular (r=0.213*), and biological (r=0.230**) domains of the ESSDAI at baseline. After a mean (S.D) follow-up of 21(13) months, the number of FDC networks still correlated with the final total ESSDAI (r=0.312**).Conclusion:The presence and number of FDC networks in foci represent a useful histopathological parameter able to reflect disease activity at baseline and during the follow-up, thus allowing more personalized interventions.Disclosure of Interests:None declared

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