Age-related deposition of amyloid P component in normal human testis

1989 ◽  
Vol 157 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Richard Herriot ◽  
Frederick Walker
Keyword(s):  
Human Testis ◽  
Amyloid P Component ◽  
Age Related ◽  
Normal Human ◽  
Amyloid P

Age-Related Appearance of Amyloid P Component in Human Renal Glomeruli

Nephron ◽  
1997 ◽  
Vol 77 (4) ◽  
pp. 399-403 ◽  
Author(s):  
Immo S. Rantala ◽  
Heikki J. Helin ◽  
Jukka T. Mustonen ◽  
Timo Reunala
Keyword(s):  
Amyloid P Component ◽  
Renal Glomeruli ◽  
Age Related ◽  
Amyloid P

Amyloid P component is located on elastic fibre microfibrils in normal human tissue

Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 652-654 ◽  
Author(s):  
S. M. Breathnach ◽  
Susan M. Melrose ◽  
B. Bhogal ◽  
F. C. de Beer ◽  
R. F. Dyck ◽  
...  
Keyword(s):  
Human Tissue ◽  
Elastic Fibre ◽  
Amyloid P Component ◽  
Normal Human Tissue ◽  
Normal Human ◽  
Amyloid P

Amyloid P component in normal human placentae

Placenta ◽  
1985 ◽  
Vol 6 (6) ◽  
pp. 551-554 ◽  
Author(s):  
A.M. Khan ◽  
F. Walker
Keyword(s):  
Amyloid P Component ◽  
Normal Human ◽  
Amyloid P ◽  
Human Placentae

scholarly journals Immunohistochemical Studies of Amyloid P Component Distribution in Normal Human Skin

1983 ◽  
Vol 80 (2) ◽  
pp. 86-90 ◽  
Author(s):  
Stephen M. Breathnach ◽  
Susan M. Melrose ◽  
Balbir Bhogal ◽  
Frederick C. De Beer ◽  
Martin M. Black ◽  
...  
Keyword(s):  
Human Skin ◽  
Normal Human Skin ◽  
Amyloid P Component ◽  
Component Distribution ◽  
Normal Human ◽  
Immunohistochemical Studies ◽  
Amyloid P

scholarly journals Serum amyloid P component binds to cell nuclei in vitro and to in vivo deposits of extracellular chromatin in systemic lupus erythematosus.

1989 ◽  
Vol 170 (4) ◽  
pp. 1433-1438 ◽  
Author(s):  
S M Breathnach ◽  
H Kofler ◽  
N Sepp ◽  
J Ashworth ◽  
D Woodrow ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Amyloid P Component ◽  
Calcium Dependent ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Normal Human ◽  
Amyloid P

Serum amyloid P component (SAP) is the single plasma protein that, from the milieu of whole normal human serum, undergoes specific calcium-dependent binding to isolated DNA and chromatin in vitro. We now report for the first time that SAP in whole serum also undergoes calcium-dependent binding to nuclei of epidermal cells in sections of normal human skin and to nuclei of fixed Hep-2 cells, a human epithelial cell line. Furthermore, and most importantly, SAP was detected in association with unusual globular dermal deposits of nuclear material in skin biopsies from two patients with systemic lupus erythematosus. This is the first evidence for binding of SAP to extracellular chromatin in vivo and supports the idea that SAP may have an important physiological role in the disposal of this material.

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