Severity of glomerulonephritis induced in different strains of suckling mice by infection with lymphocytic choriomeningitis virus: Correlation with amounts of endogenous interferon and circulating immune complexes

1982 ◽  
Vol 138 (4) ◽  
pp. 325-336 ◽  
Author(s):  
D. Woodrow ◽  
P. Ronco ◽  
Y. Riviere ◽  
J. Moss ◽  
I. Gresser ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Circulating Immune Complexes ◽  
Suckling Mice ◽  
Different Strains

scholarly journals IMMUNIZATION OF GUINEA PIGS WITH A MODIFIED STRAIN OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS

1937 ◽  
Vol 66 (3) ◽  
pp. 317-324 ◽  
Author(s):  
Erich Traub
Keyword(s):  
Guinea Pigs ◽  
Serial Passage ◽  
Lymphocytic Choriomeningitis ◽  
White Mouse ◽  
Lymphocytic Choriomeningitis Virus ◽  
High Virulence ◽  
Different Strains ◽  
Highly Virulent

A strain of choriomeningitis virus which was highly virulent for guinea pigs, as isolated from a naturally infected white mouse, has been markedly attenuated for guinea pigs by serial intracerebral passage through white mice. The change of virulence occurred before the 8th serial passage. The modified virus as a rule produces fever in guinea pigs but no other symptoms, and the infection is followed by a very solid immunity. Parallel passages of the same strain through guinea pigs have maintained its high virulence for this species but slightly reduced its pathogenicity for mice. These observations indicate that the differences in virulence for guinea pigs noted before (1, 2) with different strains of choriomeningitis virus obtained from infected stock mice may be due not only to differences in the susceptibility of guinea pigs but also to variations in the virulence of the virus. A marked degree of resistance was demonstrable in several guinea pigs on the 4th, 8th, and 10th day after injection with modified virus, when antivirus could not yet be detected in the serum. Circulating antivirus appears therefore to play a secondary part in their immunity, which seems to be closely associated with the tissues as in mice.

scholarly journals Severity of lymphocytic choriomeningitis virus disease in different strains of suckling mice correlates with increasing amounts of endogenous interferon.

1980 ◽  
Vol 152 (3) ◽  
pp. 633-640 ◽  
Author(s):  
Y Rivière ◽  
I Gresser ◽  
J C Guillon ◽  
M T Bandu ◽  
P Ronco ◽  
...  
Keyword(s):  
Virus Disease ◽  
Lymphocytic Choriomeningitis ◽  
Liver Lesions ◽  
Suckling Mice ◽  
Severity Of Disease ◽  
Swiss Mice ◽  
C3h Mice ◽  
Different Strains ◽  
Extent Of Disease ◽  
Intermediate Pattern

A marked difference was observed in the severity of disease in lymphocytic choriomeningitis (LCM) virus-infected suckling BALB/c, Swiss, and C3H mice. BALB/c mice had minimal liver lesions and none died, whereas C3H mice had extensive liver lesions and all mice died. An intermediate pattern was oberved for Swiss mice (36% mortality). Although there was no difference in the titers of LCM virus in the plasma or liver between these three strains of mice, there was a marked difference in the amount of interferon produced and the duration of interferonemia. C3H mice produced more interferon than Swiss mice which produced more interferon than BALB/c mice, indicating a direct correlation between the amount of interferon induced by LCM virus and the extent of disease. Inoculation of a potent anti-mouse interferon globulin markedly reduced the incidence of mortality in virus-infected C3H mice. BALB/c mice were as sensitive to the effects of interferon as C3H mice because daily administration of potent interferon preparations did induce disease in this strain. This ensemble of results supports our contention that endogenous interferon is in large part responsible for the manifestaions of acute LCM virus disease in suckling mice.

PARTICULARITIES OF THE IMMUNE RESPONSE IN PERSONS PROFESSIONNALLY EXPOSED TO BERYLLIUM

2016 ◽  
pp. 26-30
Author(s):  
K. I. Stosman ◽  
L. V. Lukovnikova
Keyword(s):  
Immune Response ◽  
Immune Complexes ◽  
Immunoglobulin E ◽  
Circulating Immune Complexes ◽  
Professional Contact ◽  
Beryllium Compounds

An examination was performed of 50 employees at an enterprise where they were in professional contact with beryllium. In most workers, it was detected an increase of interleukine-8, interferon- , growing level of immunoglobulin E and circulating immune complexes. It was shown that the contact with beryllium compounds leads to the interferon- level growth only in women. In men, alterations are identified in the direction of increased concentrations of common immunoglobulin E and circulating immune complexes.

Isolation of Circulating Immune Complexes from TB Patient Serum for Serodiagnosis

BIO-PROTOCOL ◽  
2012 ◽  
Vol 2 (11) ◽  
Author(s):  
Uma Ranganathan ◽  
Ramalingam Bethunaickan ◽  
Alamelu Raja
Keyword(s):  
Immune Complexes ◽  
Circulating Immune Complexes
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