Renal damage caused by gentamicin: A study of the effects on renal morphology and urinary enzyme excretion

1976 ◽  
Vol 118 (3) ◽  
pp. 171-182 ◽  
Author(s):  
J. M. Wellwood ◽  
D. Lovell ◽  
A. E. Thompson ◽  
J. R. Tighe
Keyword(s):  
Renal Damage ◽  
Urinary Enzyme ◽  
Renal Morphology ◽  
Urinary Enzyme Excretion

Effect of Amikacin and Gentamicin on Urinary Enzyme Excretion

1983 ◽  
Vol 17 (10) ◽  
pp. 752-753
Author(s):  
Juan Jimenez-Alonso ◽  
Luciano Barrios ◽  
Rafael Bejarano ◽  
Laura Jaimez ◽  
Francisco Perez-Jimenez ◽  
...  
Keyword(s):  
Urinary Enzyme ◽  
Urinary Enzyme Excretion

Urinary enzyme excretion by renal-transplant recipients in relation to interval after transplantation.

1982 ◽  
Vol 28 (8) ◽  
pp. 1762-1764 ◽  
Author(s):  
K Jung ◽  
J Diego ◽  
D Scholz ◽  
K Schröder ◽  
V Strobelt
Keyword(s):  
Renal Transplant ◽  
Reference Group ◽  
Transplant Rejection ◽  
Early Period ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Renal Disorder ◽  
Urinary Enzyme ◽  
Daily Dose ◽  
Urinary Enzyme Excretion

Abstract We determined the urinary excretion of the enzymes aminopeptidase (EC 3.4.11.2), alkaline phosphatase (EC 3.1.3.1), gamma-glutamyltransferase (EC 2.3.2.2), and N-acetyl-beta-glucosaminidase (EC 3.2.1.30) in two groups of renal-transplant recipients at different times after transplantation (1.8 months and 52 months, respectively). Both groups of patients showed a higher rate of enzyme excretion than did a reference group of healthy persons. More aminopeptidase and N-acetyl-beta-glucosaminidase were excreted during the early period after transplantation than later. The time-dependence of urinary enzyme excretion was confirmed in six renal-transplant recipients studied during the course of 15 months after transplantation. There was a general correlation between the extent of urinary enzyme excretion and both the time after transplantation and the daily dose of prednisolone. Therefore, it is necessary to take into account this influence on the extent of urinary enzyme in renal-transplant recipients if urinary enzyme excretion is used as an indicator of renal disorder and especially as an early predictor of transplant rejection.

scholarly journals Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Rizwana Afroz ◽  
E. M. Tanvir ◽  
Md. Fuad Hossain ◽  
Siew Hua Gan ◽  
Mashud Parvez ◽  
...  
Keyword(s):  
Honey Bees ◽  
Renal Damage ◽  
Serum Alkaline Phosphatase ◽  
Antioxidant Properties ◽  
Organ Damage ◽  
Modern Medicine ◽  
Complex Compounds ◽  
Protective Effects ◽  
Renal Morphology ◽  
Male Wistar Rats

Honey, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine. In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and nephrotoxicity in experimental rats were investigated. Adult male Wistar rats were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of hepatotoxicity and nephrotoxicity via the oral administration of a single dose of APAP (2 g/kg). Organ damage was confirmed by measuring the elevation of serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total protein (TP), total bilirubin (TB), urea, creatinine, and malondialdehyde (MDA). Histopathological alterations observed in the livers and the kidneys further confirmed oxidative damage to these tissues. Animals pretreated with Sundarban honey showed significantly markedly reduced levels of all of the investigated parameters. In addition, Sundarban honey ameliorated the altered hepatic and renal morphology in APAP-treated rats. Overall, our findings indicate that Sundarban honey protects against APAP-induced acute hepatic and renal damage, which could be attributed to the honey’s antioxidant properties.

scholarly journals Effects of Isoproterenol on urinary enzyme excretion in anesthetized dog

1982 ◽  
Vol 32 ◽  
pp. 57
Author(s):  
Satoshi Akabane ◽  
Minoru Kawamura ◽  
Koichi Ogino ◽  
Keiichi Ito
Keyword(s):  
Urinary Enzyme ◽  
Urinary Enzyme Excretion
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