The effect of recently isolated strains of rift valley fever virus on lamb testis cell cultures

1963 ◽  
Vol 86 (2) ◽  
pp. 530-532 ◽  
Author(s):  
W. Coackley
Keyword(s):  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Lethal mutagenesis of Rift Valley fever virus induced by favipiravir

2019 ◽  
Author(s):  
Belén Borrego ◽  
Ana I. de Ávila ◽  
Esteban Domingo ◽  
Alejandro Brun
Keyword(s):  
Animal Models ◽  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Nucleotide Sequence Analysis ◽  
African Countries ◽  
Valley Fever ◽  
Lethal Mutagenesis

ABSTRACTRift Valley fever virus (RVFV) is an emerging, mosquito-borne, zoonotic pathogen with recurrent outbreaks paying a considerable toll of human deaths in many African countries, for which no effective treatment is available. In cell culture studies and with laboratory animal models, the nucleoside analogue favipiravir (T-705) has demonstrated great potential for the treatment of several seasonal, chronic and emerging RNA virus infections of humans, suggesting applicability to control some viral outbreaks. Treatment with favipiravir was shown to reduce the infectivity of Rift Valley fever virus both in cell cultures and in experimental animal models, but the mechanism of this protective effect is not understood. In this work we show that favipiravir at concentrations well below the toxicity threshold estimated for cells is able to extinguish RVFV from infected cell cultures. Nucleotide sequence analysis has documented RVFV mutagenesis associated with virus extinction, with a significant increase in G to A and C to U transition frequencies, and a decrease of specific infectivity, hallmarks of lethal mutagenesis.

scholarly journals Evaluation of Factors Related to Growth of Rift Valley Fever Virus in Suspended Cell Cultures

1969 ◽  
Author(s):  
Jerry S. Walker ◽  
Richard C. Carter ◽  
Frederick Klein ◽  
Shirley E. Snowden ◽  
Ralph E. Lincoln
Keyword(s):  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Suspended Cell ◽  
Valley Fever

Morphology and development of Rift Valley fever virus in vero cell cultures

1988 ◽  
Vol 24 (2) ◽  
pp. 161-174 ◽  
Author(s):  
D. S. Ellis ◽  
P. V. Shirodaria ◽  
Elizabeth Fleming ◽  
D. I. H. Simpson
Keyword(s):  
Vero Cell ◽  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Evaluation of Factors Related to Growth of Rift Valley Fever Virus in Suspended Cell Cultures

1969 ◽  
Vol 17 (5) ◽  
pp. 658-664 ◽  
Author(s):  
Jerry S. Walker ◽  
Richard C. Carter ◽  
Frederick Klein ◽  
Shirley E. Snowden ◽  
Ralph E. Lincoln
Keyword(s):  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Suspended Cell ◽  
Valley Fever

scholarly journals Lethal Mutagenesis of Rift Valley Fever Virus Induced by Favipiravir

2019 ◽  
Vol 63 (8) ◽  
Author(s):  
Belén Borrego ◽  
Ana I. de Ávila ◽  
Esteban Domingo ◽  
Alejandro Brun
Keyword(s):  
Animal Models ◽  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Nucleotide Sequence Analysis ◽  
African Countries ◽  
Valley Fever ◽  
Lethal Mutagenesis

ABSTRACT Rift Valley fever virus (RVFV) is an emerging, mosquito-borne, zoonotic pathogen with recurrent outbreaks taking a considerable toll in human deaths in many African countries, for which no effective treatment is available. In cell culture studies and with laboratory animal models, the nucleoside analogue favipiravir (T-705) has demonstrated great potential for the treatment of several seasonal, chronic, and emerging RNA virus infections in humans, suggesting applicability to control some viral outbreaks. Treatment with favipiravir was shown to reduce the infectivity of Rift Valley fever virus both in cell cultures and in experimental animal models, but the mechanism of this protective effect is not understood. In this work, we show that favipiravir at concentrations well below the toxicity threshold estimated for cells is able to extinguish RVFV from infected cell cultures. Nucleotide sequence analysis has documented RVFV mutagenesis associated with virus extinction, with a significant increase in G to A and C to U transition frequencies and a decrease of specific infectivity, hallmarks of lethal mutagenesis.

scholarly journals Evaluation of Factors Related to Growth of Rift Valley Fever Virus in Suspended Cell Cultures

1969 ◽  
Vol 17 (5) ◽  
pp. 658-664
Author(s):  
Jerry S. Walker ◽  
Richard C. Carter ◽  
Frederick Klein ◽  
Shirley E. Snowden ◽  
Ralph E. Lincoln
Keyword(s):  
Cell Cultures ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Suspended Cell ◽  
Valley Fever

Complement fixation reaction of Rift Valley fever virus

1950 ◽  
Vol 5 (5) ◽  
pp. 243-247
Author(s):  
Minoru MATSUMOTO ◽  
Saburo IWASA ◽  
Motosige ENDO
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Complement Fixation ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Fixation Reaction
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