Electron microscopy of rat liver cells in hypoxia

1960 ◽  
Vol 79 (1) ◽  
pp. 179-183 ◽  
Author(s):  
Maria Bassi ◽  
A. Bernelli-Zazzera ◽  
Elena Cassi
Keyword(s):  
Electron Microscopy ◽  
Rat Liver ◽  
Liver Cells ◽  
Rat Liver Cells

Effects of Hypophysectomy on the Fine Structure of Rat Liver Cells

1967 ◽  
Vol 25 ◽  
pp. 156-157
Author(s):  
Robert R. Cardell
Keyword(s):  
Electron Microscopy ◽  
Fine Structure ◽  
Rat Liver ◽  
Liver Cell ◽  
Anterior Pituitary ◽  
Liver Cells ◽  
Biochemical Studies ◽  
Liver Functions ◽  
Rat Liver Cells ◽  
And Control

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.

scholarly journals A LIGHT AND ELECTRON MICROSCOPE STUDY OF THE MORPHOLOGICAL CHANGES INDUCED IN RAT LIVER CELLS BY THE AZO DYE 2-ME-DAB

1964 ◽  
Vol 22 (1) ◽  
pp. 143-172 ◽  
Author(s):  
J. G. Lafontaine ◽  
C. Allard
Keyword(s):  
Electron Microscopy ◽  
Rat Liver ◽  
Morphological Changes ◽  
Light And Electron Microscopy ◽  
Specific Effect ◽  
Liver Cells ◽  
Cytoplasmic Inclusions ◽  
Morphological Alterations ◽  
Hepatic Cells ◽  
Rat Liver Cells

The cytological changes induced in rat liver cells by the aminoazo dye 2-Me-DAB have been examined by light and electron microscopy. It is observed that this non-carcinogenic compound duplicates most of the morphological alterations produced by other hepatotoxins, some of which, such as the closely related aminoazo dye 3'-Me-DAB, are potent carcinogens. These non-specific effects involve both the granular and agranular forms of the endoplasmic reticulum as well as the glycogen content of hepatic cells. The arrays of cisternal profiles of the granular reticulum in normal hepatic cells become disorganized and the dispersed cisternae often appear fragmented and irregular. Large cytoplasmic inclusions, consisting of loosely organized tubules and vesicles, are also observed which result from a hypertrophy of the agranular reticulum. The glycogen in the cells progressively decreases in amount. The most specific effect of 2-Me-DAB is to induce an increase in the number of mitochondria per cell. Many of these organelles are characterized by the presence of a median double membrane continuous with the inner limiting membrane of the mitochondrial envelope. Evidence is presented in favor of the view that this partition is directly related to the phenomenon of mitochondrial division. It was noted also in the course of the experiment that an increasing number of cells appear which stain quite intensely with methylene blue and appear denser than normal under electron microscopy. The significance of these cells is not known.

Vacuolar Degeneration of Rat Liver Cells by Electron Microscopy

Nature ◽  
1957 ◽  
Vol 179 (4553) ◽  
pp. 256-257 ◽  
Author(s):  
MARIA BASSI ◽  
ALDO BERNELLI-ZAZZERA
Keyword(s):  
Electron Microscopy ◽  
Rat Liver ◽  
Liver Cells ◽  
Vacuolar Degeneration ◽  
Rat Liver Cells

Heterogeneity of carboxylesterases in rat liver cells

1992 ◽  
Vol 44 (4) ◽  
pp. 827-829 ◽  
Author(s):  
Rolf Gaustad ◽  
Trond Berg ◽  
Frode Fonnum
Keyword(s):  
Rat Liver ◽  
Liver Cells ◽  
Rat Liver Cells
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