Wnt signalling and the mechanistic basis of tumour development

2005 ◽  
Vol 205 (2) ◽  
pp. 130-144 ◽  
Author(s):  
Mohammad Ilyas
Keyword(s):  
Wnt Signalling ◽  
Tumour Development ◽  
Mechanistic Basis

scholarly journals WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Atsushi Sato ◽  
Masahiro Shimizu ◽  
Toshiyasu Goto ◽  
Hiroyuki Masuno ◽  
Hiroyuki Kagechika ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Therapeutic Target ◽  
E3 Ubiquitin Ligase ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Tumour Development ◽  
Wnt Signalling Pathway

Abstractβ-Catenin is an important component of the Wnt signalling pathway. As dysregulation or mutation of this pathway causes many diseases, including cancer, the β-Catenin level is carefully regulated by the destruction complex in the Wnt signalling pathway. However, the mechanisms underlying the regulation of β-Catenin ubiquitination and degradation remain unclear. Here, we find that WNK (With No Lysine [K]) kinase is a potential regulator of the Wnt signalling pathway. We show that WNK protects the interaction between β-Catenin and the Glucose-Induced degradation Deficient (GID) complex, which includes an E3 ubiquitin ligase targeting β-Catenin, and that WNK regulates the β-Catenin level. Furthermore, we show that WNK inhibitors induced β-Catenin degradation and that one of these inhibitors suppressed xenograft tumour development in mice. These results suggest that WNK is a previously unrecognized regulator of β-Catenin and a therapeutic target of cancer.

scholarly journals PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Coralie Drelon ◽  
Annabel Berthon ◽  
Isabelle Sahut-Barnola ◽  
Mickaël Mathieu ◽  
Typhanie Dumontet ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Malignant Tumour ◽  
Wnt Signalling ◽  
Tumour Development

scholarly journals Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint

2018 ◽  
Vol 373 (1759) ◽  
pp. 20170329 ◽  
Author(s):  
Rebecca A. Rolfe ◽  
Claire A. Shea ◽  
Pratik Narendra Pratap Singh ◽  
Amitabha Bandyopadhyay ◽  
Paula Murphy
Keyword(s):  
Mechanical Stimulation ◽  
Wnt Pathway ◽  
Molecular Mechanisms ◽  
Skeletal Development ◽  
Wnt Signalling ◽  
Mechanical Stimuli ◽  
Mechanistic Basis ◽  
Bmp Signalling ◽  
Canonical Wnt ◽  
Mechanical Influence

Embryo movement is essential to the formation of a functional skeleton. Using mouse and chick models, we previously showed that mechanical forces influence gene regulation and tissue patterning, particularly at developing limb joints. However, the molecular mechanisms that underpin the influence of mechanical signals are poorly understood. Wnt signalling is required during skeletal development and is altered under reduced mechanical stimulation. Here, to explore Wnt signalling as a mediator of mechanical input, the expression of Wnt ligand and Fzd receptor genes in the developing skeletal rudiments was profiled. Canonical Wnt activity restricted to the developing joint was shown to be reduced under immobilization, while overexpression of activated β-catenin following electroporation of chick embryo limbs led to joint expansion, supporting the proposed role for Wnt signalling in mechanoresponsive joint patterning. Two key findings advance our understanding of the interplay between Wnt signalling and mechanical stimuli: first, loss of canonical Wnt activity at the joint shows reciprocal, coordinated misregulation of BMP signalling under altered mechanical influence. Second, this occurs simultaneously with increased expression of several Wnt pathway component genes in a territory peripheral to the joint, indicating the importance of mechanical stimulation for a population of potential joint progenitor cells. This article is part of the Theo Murphy meeting issue ‘Mechanics of Development’.

Down regulation of osteopontin interferes with HCV replication by inhibition of WNT signalling in vitro

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
C Loscher ◽  
R Bartenschlager ◽  
V Lohmann ◽  
G Tiegs ◽  
G Sass
Keyword(s):  
Wnt Signalling ◽  
Down Regulation

Severe Head Injury linked to Subsequent Development of Malignant Brain Tumour within a Short Period- A Case Report

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Head Injury ◽  
Brain Tumour ◽  
Severe Head Injury ◽  
Case Reports ◽  
Subsequent Development ◽  
Malignant Brain Tumour ◽  
Tumour Development ◽  
Short Period ◽  
The Brain

There have been a few case reports of head injury leading to brain tumour development in the same region as the brain injury. Here we report a case where the patient suffered a severe head injury with contusion. He recovered clinically with conservative management. Follow up Computed Tomography scan of the brain a month later showed complete resolution of the lesion. He subsequently developed malignant brain tumour in the same region as the original contusion within a very short period of 15 months. Head injury patients need close follow up especially when severe. The link between severity of head injury and malignant brain tumour development needs further evaluation. Role of anti-inflammatory agents for prevention of post traumatic brain tumours needs further exploration.

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