The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer

2003 ◽  
Vol 200 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Didier Ferbus ◽  
Christophe Bovin ◽  
Pierre Validire ◽  
Gérard Goubin
Keyword(s):  
Colorectal Cancer ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein

scholarly journals Diagnostic Potential of Zinc Finger Protein-Specific Autoantibodies and Associated Linear B-Cell Epitopes in Colorectal Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123469 ◽  
Author(s):  
Julie-Ann O’Reilly ◽  
Jenny Fitzgerald ◽  
Seán Fitzgerald ◽  
Dermot Kenny ◽  
Elaine W. Kay ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
B Cell ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
B Cell Epitopes ◽  
Finger Protein ◽  
Diagnostic Potential ◽  
Linear B

Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation

2015 ◽  
Vol 466 (3) ◽  
pp. 499-509 ◽  
Author(s):  
Yongsheng Huang ◽  
Peng Wang ◽  
Hua Chen ◽  
Yi Ding ◽  
Ye-Guang Chen
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Wnt Signalling ◽  
Negative Regulator ◽  
Proliferative Effect ◽  
Finger Protein ◽  
And Migration ◽  
Wnt3a Stimulation

Wnt signalling regulates embryonic development and tissue homoeostasis by modulating cell proliferation, differentiation and migration. Dapper1 (Dpr1) has been shown to be an important key negative regulator of Wnt signalling by promoting Dishevelled (Dvl) degradation. In the present study, we found that Myc-interacting zinc-finger protein 1 (MIZ1) interacts with Dpr1 and this interaction attenuates the ability of Dpr1 to induce Dvl2 degradation, thus enhancing Wnt signalling. Mechanistically, MIZ1 is translocated from the nucleus to the cytoplasm upon Wnt3a stimulation or overexpression of Dpr1 and Dvl2, disrupting the interaction between Dpr1 and Dvl2. Furthermore, MIZ1 can promote the proliferation of breast cancer MDA-MB-231 and BT-549 cells through Wnt signalling and reverse the anti-proliferative effect of Dpr1 on colorectal cancer Caco-2. Together, our findings establish a novel layer of Wnt signalling regulation via the MIZ1–Dpr1–Dvl axis.

scholarly journals Identification of zinc finger protein of the cerebellum 5 as a survival factor of prostate and colorectal cancer cells

2017 ◽  
Vol 108 (12) ◽  
pp. 2405-2412 ◽  
Author(s):  
Reiko Satow ◽  
Shota Inagaki ◽  
Chiaki Kato ◽  
Makoto Shimozawa ◽  
Kiyoko Fukami
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Survival Factor ◽  
Finger Protein ◽  
Colorectal Cancer Cells

scholarly journals Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abdul K. Siraj ◽  
Sandeep Kumar Parvathareddy ◽  
Nabil Siraj ◽  
Khadija Al-Obaisi ◽  
Saud M. Aldughaither ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Protein Expression ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Middle Eastern ◽  
Clinical Prognosis ◽  
Mesenchymal Transition ◽  
Finger Protein ◽  
Potential Biomarker

AbstractZinc-finger proteins are transcription factors with a “finger-like” domain that are widely involved in many biological processes. The zinc-finger protein 677 (ZNF677) belongs to the zinc-finger protein family. Previous reports have highlighted the tumor suppressive role of ZNF677 in thyroid and lung cancer. However, its role in colorectal cancer (CRC) has not been explored. ZNF677 protein expression was analyzed by immunohistochemistry in a large cohort of 1158 CRC patients. ZNF677 loss of expression was more frequent in CRC tissues (45.3%, 525/1158), when compared to that of normal tissue (5.1%, 11/214) (p < 0.0001) and was associated with mucinous histology (p = 0.0311), advanced pathological stage (p < 0.0001) and lymph node (LN) metastasis (p = 0.0374). Further analysis showed ZNF677 loss to be significantly enriched in LN metastatic CRC compared to overall cohort (p = 0.0258). More importantly, multivariate logistic regression analysis showed that ZNF677 loss is an independent predictor of LN metastasis in CRC (Odds ratio = 1.41; 95% confidence interval 1.05–1.87; p = 0.0203).The gain- and loss-of-function studies in CRC cell lines demonstrated that loss of ZNF677 protein expression prominently increased cell proliferation, progression of epithelial-mesenchymal transition and conferred chemoresistance, whereas its overexpression reversed the effect. In conclusion, loss of ZNF677 protein expression is common in Middle Eastern CRC and contributes to the prediction of biological aggressiveness of CRC. Therefore, ZNF677 could not only serve as a marker in predicting clinical prognosis in patient with CRC but also as a potential biomarker for personalized targeted therapy.

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