scholarly journals Poly(2‐ethyl‐2‐oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

2021 ◽  
Author(s):  
Janni Lavikainen ◽  
Moldir Dauletbekova ◽  
Gaukhar Toleutay ◽  
Maria Kaliva ◽  
Maria Chatzinikolaidou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Gellan Gum

Co-polymerized Gellan Gum: A Carrier for Controlled Drug Delivery

2016 ◽  
Vol 5 (3) ◽  
pp. 151-162
Author(s):  
Ranjeet Pareek ◽  
Shakuntla Verma ◽  
Viney Lather ◽  
Deepti Pandita
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Gellan Gum

Synthesis of PMMA-b-PS Block Copolymer by Emulsion ATRP and its Self-Assembly Property

2013 ◽  
Vol 705 ◽  
pp. 115-119
Author(s):  
Bao Yong Tian ◽  
Er Jun Tang ◽  
Miao Yuan ◽  
Rui Xia Hao ◽  
Cun Man Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Self Assembly ◽  
Potential Application ◽  
Morphological Characteristic ◽  
Living Polymerization ◽  
The Self ◽  
Emulsion System ◽  
Copolymer Concentration ◽  
Ft Ir

The well-defined block copolymer PMMA-b-PS was prepared by two-step ATRP in emulsion system. GPC results indicate that Mn increased linearly with conversion and polydispersity remained relatively narrow. It presents the characteristics of living polymerization in emulsion system. FT-IR demonstrated that block copolymer PMMA-b-PS could be successfully synthesized by ATRP with macroinitiator PMMA-Cl in emulsion system. The morphological characteristic of the self-assembly depends on the block copolymer concentration and transforms between spheres and rodlike micelles. The property indicates a perfect potential application in drug delivery materials.

Synthesis of calcium carbonate nanocrystals and their potential application as vessels for drug delivery

2015 ◽  
Author(s):  
Viviana Vergaro ◽  
Elisabetta Carata ◽  
Elisa Panzarini ◽  
Francesca Baldassare ◽  
Luciana Dini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Potential Application

Sericin/RBA embedded gellan gum based smart nanosystem for pH responsive drug delivery

2018 ◽  
Vol 120 ◽  
pp. 1561-1571 ◽  
Author(s):  
Mukherjee Arjama ◽  
Sivaraj Mehnath ◽  
Mariappan Rajan ◽  
Murugaraj Jeyaraj
Keyword(s):  
Drug Delivery ◽  
Gellan Gum ◽  
Ph Responsive

scholarly journals Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery

2014 ◽  
Vol 5 (22) ◽  
pp. 6461-6471 ◽  
Author(s):  
Sarah Decato ◽  
Troy Bemis ◽  
Eric Madsen ◽  
Sandro Mecozzi
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Amphiphilic Polymers ◽  
Synthesis And Characterization ◽  
Hydrophobic Drug ◽  
Tert Butyl ◽  
Theranostic Applications ◽  
Polymer Surfactants

Semifluorinated polymer surfactants containing one, two, or three perfluoro-tert-butyl groups were synthesized and fully characterized. Theranostic applications are discussed.

scholarly journals Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 187 ◽  
Author(s):  
Alessandra Adrover ◽  
Patrizia Paolicelli ◽  
Stefania Petralito ◽  
Laura Di Muzio ◽  
Jordan Trilli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vitamin B12 ◽  
Drug Delivery Systems ◽  
Moving Boundary ◽  
Delivery Systems ◽  
Gellan Gum ◽  
Simulated Gastric Fluid ◽  
Sustained Drug Delivery ◽  
Porous Beads ◽  
Swelling Model

In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare polymeric beads. Rheological studies and preliminary experiments of beads preparation allowed to identify the GG and the CaCl2 concentrations suitable for obtaining stable and spherical particles. GG beads were formed, through ionotropic gelation technique, with and without the presence of the synthetic clay laponite. The resultant beads were analyzed for dimensions (before and after freeze-drying), morphological aspects and ability to swell in different media miming biological fluids, namely SGF (Simulated Gastric Fluid, HCl 0.1 M) and SIF (Simulated Intestinal Fluid, phosphate buffer, 0.044 M, pH 7.4). The swelling degree was lower in SGF than in SIF and further reduced in the presence of laponite. The GG and GG-layered silicate composite beads were loaded with two model drugs having different molecular weight, namely theophylline and cyanocobalamin (vitamin B12) and subjected to in-vitro release studies in SGF and SIF. The presence of laponite in the bead formulation increased the drug entrapment efficiency and slowed-down the release kinetics of both drugs in the gastric environment. A moving-boundary swelling model with “diffuse” glassy-rubbery interface was proposed in order to describe the swelling behavior of porous freeze-dried beads. Consistently with the swelling model adopted, two moving-boundary drug release models were developed to interpret release data from highly porous beads of different drugs: drug molecules, e.g., theophylline, that exhibit a typical Fickian behavior of release curves and drugs, such as vitamin B12, whose release curves are affected by the physical/chemical interaction of the drug with the polymer/clay complex. Theoretical results support the experimental observations, thus confirming that laponite may be an effective additive for fabricating sustained drug delivery systems.

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