Stimuli‐responsive polyurethane bionanocomposites of poly(ethylene glycol)/poly(ε‐caprolactone) and [poly(ε‐caprolactone)‐grafted‐] cellulose nanocrystals

2020 ◽  
Vol 32 (1) ◽  
pp. 76-86 ◽  
Author(s):  
Hanieh Aghaiee Ranjbar ◽  
Mohammad Nourany ◽  
Majid Mollavali ◽  
Fatemeh Noormohammadi ◽  
Safora Jafari
Keyword(s):  
Ethylene Glycol ◽  
Cellulose Nanocrystals ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-poly(vinyl alcohol)-adamantanate: synthesis and stimuli-responsive micelle properties

Soft Matter ◽  
2012 ◽  
Vol 8 (21) ◽  
pp. 5843 ◽  
Author(s):  
Wei Deng ◽  
Jing Chen ◽  
Aditya Kulkarni ◽  
David H. Thompson
Keyword(s):  
Ethylene Glycol ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Stimuli-Responsive Drug Delivery of Doxorubicin Using Magnetic Nanoparticle Conjugated Poly(ethylene glycol)-g-Chitosan Copolymer

2021 ◽  
Vol 22 (23) ◽  
pp. 13169
Author(s):  
Hyun-Min Yoon ◽  
Min-Su Kang ◽  
Go-Eun Choi ◽  
Young-Joon Kim ◽  
Chang-Hyu Bae ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Anticancer Drug ◽  
Drug Targeting ◽  
Water Soluble ◽  
Morphological Observation ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Magnetic Stimulus ◽  
Magnetic Sensitivity ◽  
Poly Ethylene

Stimuli-responsive nanoparticles are regarded as an ideal candidate for anticancer drug targeting. We synthesized glutathione (GSH) and magnetic-sensitive nanocomposites for a dual-targeting strategy. To achieve this goal, methoxy poly (ethylene glycol) (MePEG) was grafted to water-soluble chitosan (abbreviated as ChitoPEG). Then doxorubicin (DOX) was conjugated to the backbone of chitosan via disulfide linkage. Iron oxide (IO) magnetic nanoparticles were also conjugated to the backbone of chitosan to provide magnetic sensitivity. In morphological observation, images from a transmission electron microscope (TEM) showed that IO nanoparticles were embedded in the ChitoPEG/DOX/IO nanocomposites. In a drug release study, GSH addition accelerated DOX release rate from nanocomposites, indicating that nanocomposites have redox-responsiveness. Furthermore, external magnetic stimulus concentrated nanocomposites in the magnetic field and then provided efficient internalization of nanocomposites into cancer cells in cell culture experiments. In an animal study with CT26 cell-bearing mice, nanocomposites showed superior magnetic sensitivity and then preferentially targeted tumor tissues in the field of external magnetic stimulus. Nanocomposites composed of ChitoPEG/DOX/IO nanoparticle conjugates have excellent anticancer drug targeting properties.

Thermoresponsive poly(poly(ethylene glycol) methylacrylate)s grafted cellulose nanocrystals through SI-ATRP polymerization

Cellulose ◽  
2017 ◽  
Vol 24 (10) ◽  
pp. 4189-4203 ◽  
Author(s):  
Xiuqiang Zhang ◽  
Jinlong Zhang ◽  
Lili Dong ◽  
Suxia Ren ◽  
Qinglin Wu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Cellulose Nanocrystals ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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