Polycaprolactone‐based hotmelt adhesive for hernia‐mesh fixation

2020 ◽  
Vol 31 (12) ◽  
pp. 3194-3201
Author(s):  
Sabrina Roisman ◽  
Ana L. Dotan ◽  
Dan Y. Lewitus
Keyword(s):  
Mesh Fixation ◽  
Hernia Mesh ◽  
Hotmelt Adhesive

scholarly journals P044 ATRAUMATIC AND CONSISTENT HERNIA MESH FIXATION: PERFORMANCE AND SAFETY IN A LAPAROSCOPIC IPOM PORCINE MODEL

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Miguel Lopes ◽  
Elisa Bitton ◽  
Elise Devries ◽  
Maria Pereira
Keyword(s):  
Histological Analysis ◽  
Porcine Model ◽  
Mesh Fixation ◽  
Fixation Strength ◽  
Tissue Ingrowth ◽  
Hernia Mesh ◽  
Local Tissue ◽  
Abdominal Adhesion ◽  
Mesh Shrinkage

Abstract Aim Demonstrate the performance and safety of TISSIUM on-demand activated adhesive for atraumatic hernia mesh fixation in a laparoscopic IPOM porcine model. Material and Methods Full thickness 4 cm in diameter excisional abdominal defects (n = 14) were created in pig (n = 8). The defects were repaired through laparoscopic intraperitoneal mesh placement using commercial composite meshes fixed with TISSIUM adhesive (n = 8) or resorbable tacks (n = 6). The animals were sacrificed after 28 and 90 days. An independent pathologist evaluated abdominal adhesion, mesh shrinkage, local tissue tolerance and tissue ingrowth through histological analysis (H&E and Movat Pentacrome) at sacrifice. Fixation strength of the explanted abdominal walls was also assessed via burst-ball. Results No adverse events were observed at implantation or during the survival period. All the meshes were in place at sacrifice. Mesh shrinkage and abdominal adhesion scores were similar between the two groups. Histological analysis of the mesh demonstrated equivalent quality of tissue ingrowth and excellent local tissue tolerance with minimal/mild foreign body response and mononuclear cells inflammation. The repair strength, evaluated through a burst ball method 90 days after implantation, showed no significant difference between the TISSIUM adhesive and tacks. Usability is currently being evaluated in clinically relevant models. Conclusions In this preclinical study the TISSIUM adhesive demonstrated similar fixation strength and quality of repair when compared to commercial tacks. This technology has the potential to impact hernia procedures standardization and reduce pain often associated with current fixation technologies.

Transcolonic ventral wall hernia mesh fixation in a porcine model

Endoscopy ◽  
2007 ◽  
Vol 39 (10) ◽  
pp. 865-869 ◽  
Author(s):  
D. Fong ◽  
M. Ryou ◽  
R. Pai ◽  
A. Tavakkolizadeh ◽  
D. Rattner ◽  
...  
Keyword(s):  
Porcine Model ◽  
Mesh Fixation ◽  
Hernia Mesh ◽  
Ventral Wall

A Comparative Biomechanical Evaluation of Hernia Mesh Fixation by Fibrin Sealant

2011 ◽  
Vol 171 (2) ◽  
pp. 576-581 ◽  
Author(s):  
René H. Fortelny ◽  
Alexander H. Petter-Puchner ◽  
James Ferguson ◽  
Simone Gruber-Blum ◽  
Julian Brand ◽  
...  
Keyword(s):  
Fibrin Sealant ◽  
Mesh Fixation ◽  
Hernia Mesh ◽  
Biomechanical Evaluation

A comparison of a bovine albumin/glutaraldehyde glue versus fibrin sealant for hernia mesh fixation in experimental onlay and IPOM repair in rats

2010 ◽  
Vol 24 (12) ◽  
pp. 3086-3094 ◽  
Author(s):  
S. Gruber-Blum ◽  
A. H. Petter-Puchner ◽  
K. Mika ◽  
J. Brand ◽  
H. Redl ◽  
...  
Keyword(s):  
Fibrin Sealant ◽  
Mesh Fixation ◽  
Bovine Albumin ◽  
Hernia Mesh

scholarly journals P046 ATRAUMATIC AND CONSISTENT HERNIA MESH FIXATION: PERFORMANCE AND SAFETY IN A LAPAROSCOPIC IPOM PORCINE MODEL

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Miguel Lopes ◽  
Elisa Bitton ◽  
Elise Devries ◽  
Maria Pereira
Keyword(s):  
Histological Analysis ◽  
Porcine Model ◽  
Mesh Fixation ◽  
Fixation Strength ◽  
Tissue Ingrowth ◽  
Hernia Mesh ◽  
Local Tissue ◽  
Abdominal Adhesion ◽  
Mesh Shrinkage

Abstract Aim Demonstrate the performance and safety of TISSIUM on-demand activated adhesive for atraumatic hernia mesh fixation in a laparoscopic IPOM porcine model. Material and Methods Full thickness 4 cm in diameter excisional abdominal defects (n = 14) were created in pig (n = 8). The defects were repaired through laparoscopic intraperitoneal mesh placement using commercial composite meshes fixed with TISSIUM adhesive (n = 8) or resorbable tacks (n = 6). The animals were sacrificed after 28 and 90 days. An independent pathologist evaluated abdominal adhesion, mesh shrinkage, local tissue tolerance and tissue ingrowth through histological analysis (H&E and Movat Pentacrome) at sacrifice. Fixation strength of the explanted abdominal walls was also assessed via burst-ball. Results No adverse events were observed at implantation or during the survival period. All the meshes were in place at sacrifice. Mesh shrinkage and abdominal adhesion scores were similar between the two groups. Histological analysis of the mesh demonstrated equivalent quality of tissue ingrowth and excellent local tissue tolerance with minimal/mild foreign body response and mononuclear cells inflammation. The repair strength, evaluated through a burst ball method 90 days after implantation, showed no significant difference between the TISSIUM adhesive and tacks. Usability is currently being evaluated in clinically relevant models. Conclusions In this preclinical study the TISSIUM adhesive demonstrated similar fixation strength and quality of repair when compared to commercial tacks. This technology has the potential to impact hernia procedures standardization and reduce pain often associated with current fixation technologies.

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