scholarly journals Farnesoid X receptor ‐ a molecular predictor of weight loss after vertical sleeve gastrectomy?

2019 ◽  
Vol 5 (3) ◽  
pp. 273-280 ◽  
Author(s):  
F. Scott ◽  
S. Elahi ◽  
M. Adebibe ◽  
U. Parampalli ◽  
K. Mannur ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Farnesoid X Receptor ◽  
Vertical Sleeve Gastrectomy ◽  
Molecular Predictor

scholarly journals Effect of vertical sleeve gastrectomy on food selection and satiation in rats

2012 ◽  
Vol 303 (8) ◽  
pp. E1076-E1084 ◽  
Author(s):  
Adam P. Chambers ◽  
Hilary E. Wilson-Perez ◽  
Sean McGrath ◽  
Bernadette E. Grayson ◽  
Karen K. Ryan ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Area Postrema ◽  
Food Selection ◽  
Nutrient Sensing ◽  
Ingestive Behavior ◽  
Neuronal Activation ◽  
Vertical Sleeve Gastrectomy ◽  
Caloric Density ◽  
Dietary Preferences

Vertical sleeve gastrectomy (VSG) is a restrictive procedure that reduces food intake to produce weight loss. Here we assess volume and nutrient effects on the ingestive behavior of VSG and sham surgery animals. Rats given access to Ensure or pelleted chow were used to determine if liquid foods would adversely affect weight loss after surgery. Volume effects were studied by altering the caloric density of Ensure, and dietary preferences for fat and carbohydrate (sucrose) were assessed using a two-bottle test. c-Fos was used to measure neuronal activation in the nucleus of the solitary tract and area postrema in response to intragastric infusions of water, sucrose, or Intralipid. The degree of colocalization with catecholaminergic neurons was also assessed. VSG rats did not show the expected preference for a liquid diet over chow and lacked dietary preferences for fat seen in shams. Preferences for carbohydrate/sucrose solutions were unaffected by surgery. Meal size was reduced by VSG; however, VSG rats were able to alter their volume of intake to compensate for changes in caloric density, and intragastric infusions of water produced similar levels of neuronal activation among VSG, sham, and pair-fed rats. In comparison, nutrient-induced c-Fos activation was substantially increased by VSG. Colocalization between c-Fos and catecholaminergic-expressing neurons was similar among rats treated with water, sucrose, or Intralipid. VSG alters nutrient sensing in a manner that lowers the threshold for satiety and reduces fat preference to induce and maintain weight loss.

scholarly journals Elevated Plasma Endothelin‐1 is Associated with Reduced Weight Loss Post‐Vertical Sleeve Gastrectomy

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Haley N Jenkins ◽  
London J Williams ◽  
Adam S Dungey ◽  
Kenneth D Vick ◽  
Bernadette E Grayson ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Elevated Plasma ◽  
Vertical Sleeve Gastrectomy ◽  
Endothelin 1

scholarly journals Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy

2019 ◽  
Vol 15 (7) ◽  
pp. 1044-1050 ◽  
Author(s):  
Haley N. Jenkins ◽  
London J. Williams ◽  
Adam Dungey ◽  
Kenneth D. Vick ◽  
Bernadette E. Grayson ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Elevated Plasma ◽  
Vertical Sleeve Gastrectomy ◽  
Endothelin 1

Comparative Effectiveness of Gastric Bypass and Vertical Sleeve Gastrectomy for Hypertension Remission and Relapse: The ENGAGE CVD Study

Hypertension ◽  
2021 ◽  
Author(s):  
Kristi Reynolds ◽  
Lee J. Barton ◽  
Anirban Basu ◽  
Heidi Fischer ◽  
David E. Arterburn ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Vertical Sleeve Gastrectomy ◽  
Variable Approach ◽  
Study Population ◽  
Instrumental Variable Approach

Weight loss is an effective strategy for the management of hypertension, and bariatric surgery is the most effective weight loss and maintenance strategy for obesity. The importance of bariatric surgery in the long-term management of hypertension and which operation is most effective is less clear. We compared the effectiveness of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) for remission and relapse of hypertension after surgery in the ENGAGE CVD cohort study (Effectiveness of Gastric Bypass Versus Gastric Sleeve for Cardiovascular Disease). Operations were done by 23 surgeons across 9 surgical practices. Hypertension remission and relapse were assessed in each year of follow-up beginning 30 days and up to 5 years postsurgery. We used a local instrumental variable approach to account for selection bias in the choice of VSG or RYGB. The study population included 4964 patients with hypertension at the time of surgery (n=3186 VSG and n=1778 RYGB). At 1 year, 27% of patients with RYGB and 28% of patients with VSG achieved remission. After 5 years, without accounting for relapse, 42% of RYGB and 43% of VSG patients had experienced hypertension remission. After accounting for relapse, only 17% of RYGB and 18% of VSG patients remained in remission 5 years after surgery. There were no statistically significant differences between VSG and RYGB for hypertension remission, relapse, or mean systolic and diastolic blood pressure at any time during follow-up.

scholarly journals Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Hepatology ◽  
2016 ◽  
Vol 64 (3) ◽  
pp. 760-773 ◽  
Author(s):  
Lili Ding ◽  
Kyle M. Sousa ◽  
Lihua Jin ◽  
Bingning Dong ◽  
Byung‐Wook Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Fatty Liver ◽  
Vertical Sleeve Gastrectomy

scholarly journals Effects of vitamin D deficiency on the improvement of metabolic disorders in obese mice after vertical sleeve gastrectomy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jie Zhang ◽  
Min Feng ◽  
Lisha Pan ◽  
Feng Wang ◽  
Pengfei Wu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Vitamin D Deficiency ◽  
Hepatic Steatosis ◽  
Metabolic Disorders ◽  
Obese Mice ◽  
Vertical Sleeve Gastrectomy ◽  
Obesity And Diabetes

AbstractVertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries for the remission of obesity and diabetes. Its effects include weight loss, improved insulin resistance, and the improvement of hepatic steatosis. Epidemiologic studies demonstrated that vitamin D deficiency (VDD) is associated with many diseases, including obesity. To explore the role of vitamin D in metabolic disorders for patients with obesity after VSG. We established a murine model of diet-induced obesity + VDD, and we performed VSGs to investigate VDD's effects on the improvement of metabolic disorders present in post-VSG obese mice. We observed that in HFD mice, the concentration of VitD3 is four fold of HFD + VDD one. In the post-VSG obese mice, VDD attenuated the improvements of hepatic steatosis, insulin resistance, intestinal inflammation and permeability, the maintenance of weight loss, the reduction of fat loss, and the restoration of intestinal flora that were weakened. Our results suggest that in post-VSG obese mice, maintaining a normal level of vitamin D plays an important role in maintaining the improvement of metabolic disorders.

scholarly journals Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner

Obesity ◽  
2013 ◽  
Vol 22 (2) ◽  
pp. 390-400 ◽  
Author(s):  
Andriy Myronovych ◽  
Michelle Kirby ◽  
Karen K. Ryan ◽  
Wujuan Zhang ◽  
Pinky Jha ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Bile Acids ◽  
Hepatic Steatosis ◽  
Vertical Sleeve Gastrectomy ◽  
Independent Manner ◽  
Serum Bile Acids

The Use of Predictive Markers for the Development of a Model to Predict Weight Loss Following Vertical Sleeve Gastrectomy

2018 ◽  
Vol 28 (12) ◽  
pp. 3769-3774 ◽  
Author(s):  
Samuel Cottam ◽  
Daniel Cottam ◽  
Austin Cottam ◽  
Hinali Zaveri ◽  
Amit Surve ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Predictive Markers ◽  
Vertical Sleeve Gastrectomy ◽  
Predict Weight Loss

scholarly journals THE ROLE OF THE SLEEVE GASTRECTOMY AND THE MANAGEMENT OF TYPE 2 DIABETES

2017 ◽  
Vol 30 (4) ◽  
pp. 283-286 ◽  
Author(s):  
Taíse FUCHS ◽  
Marcelo LOUREIRO ◽  
Gabriela Heloise BOTH ◽  
Heloise Helena SKRABA ◽  
Thaís Andrade COSTA-CASAGRANDE
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Glycemic Control ◽  
Published Data ◽  
Clinical Group ◽  
Vertical Sleeve Gastrectomy ◽  
Obesity And Diabetes ◽  
Pubmed Database

ABSTRACT Background : Currently, bariatric surgery has promoted weight loss and improved glycemic control in obese patients through different techniques, including vertical sleeve gastrectomy. Aim : Present and update the different vertical sleeve gastrectomy ways of action, both in the treatment of obesity and diabetes, approaching its potential effect on gastrointestinal physiology, as well as the benefits achieved by this manipulation. Methods : Pubmed database search was used crossing the headings: obesity, type 2 diabetes and sleeve gastrectomy. Results : Published data have shown that short-term weight loss tends to be higher in patients undergoing vertical sleeve gastrectomy compared to Roux-en-Y gastric bypass. In relation to glycemic control, the procedure demonstrated remission of diabetes in up to 60% after one year of surgery. After three years, however, differences in remission rate between surgical and clinical group was not observed, questioning the durability of the technical in a long-term. Conclusion : Despite showing good results, both in the weight loss and co-morbidities, conflicting results reinforce the need for more studies to prove the efficiency of the vertical sleeve gastrectomy as well as to understand its action about the molecular mechanisms involved in the disease.

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