scholarly journals Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles

ChemistryOpen ◽  
2016 ◽  
Vol 5 (6) ◽  
pp. 507-507
Author(s):  
Yoshitsugu Akiyama ◽  
Guoqing Wang ◽  
Shota Shiraishi ◽  
Naoki Kanayama ◽  
Tohru Takarada ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Naked Eye ◽  
Functionalized Gold Nanoparticles

scholarly journals Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles

ChemistryOpen ◽  
2016 ◽  
Vol 5 (6) ◽  
pp. 508-512 ◽  
Author(s):  
Yoshitsugu Akiyama ◽  
Guoqing Wang ◽  
Shota Shiraishi ◽  
Naoki Kanayama ◽  
Tohru Takarada ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Naked Eye ◽  
Functionalized Gold Nanoparticles

Non-enzymatic colorimetric sensor strip based on melamine-functionalized gold nanoparticles assembled on polyamide nanofiber membranes for the detection of metronidazole

2019 ◽  
Vol 11 (29) ◽  
pp. 3706-3713 ◽  
Author(s):  
Mohammed Awad Abedalwafa ◽  
Yan Li ◽  
Chunfang Ni ◽  
Gang Yang ◽  
Lu Wang
Keyword(s):  
Gold Nanoparticles ◽  
Color Change ◽  
High Sensitivity ◽  
Colorimetric Sensor ◽  
Eye Detection ◽  
Naked Eye ◽  
Functionalized Gold Nanoparticles ◽  
Sensitivity And Selectivity ◽  
Nanofiber Membranes ◽  
Naked Eye Detection

Non-enzymatic colorimetric sensor strip for detection of metronidazole (MTZ) was designed and constructed, with high sensitivity and selectivity. Which can be used for naked-eye detection of MTZ with a visible color change from pink to purple.

Naked eye detection of glutathione in living cells using rhodamine B-functionalized gold nanoparticles coupled with FRET

2012 ◽  
Vol 92 (1) ◽  
pp. 778-782 ◽  
Author(s):  
Huai-Hong Cai ◽  
Hui Wang ◽  
Jinhui Wang ◽  
Wei Wei ◽  
Pei-Hui Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Rhodamine B ◽  
Living Cells ◽  
Eye Detection ◽  
Naked Eye ◽  
Functionalized Gold Nanoparticles ◽  
Naked Eye Detection

scholarly journals pH Dependence on Colorimetric Detection of Hg2+ by Histidine-Functionalized Gold Nanoparticles

2020 ◽  
Vol 20 (4) ◽  
pp. 941
Author(s):  
Dewi Eviane ◽  
Dwi Siswanta ◽  
Sri Juari Santosa
Keyword(s):  
Gold Nanoparticles ◽  
Color Change ◽  
Ph Dependence ◽  
Colorimetric Detection ◽  
Trisodium Citrate ◽  
Industrial Facility ◽  
Naked Eye ◽  
Functionalized Gold Nanoparticles ◽  
Relative Standard ◽  
Optimum Ph

In this study, we successfully developed gold nanoparticles capped with histidine (His-AuNPs) for Hg2+ detection using trisodium citrate as the reducing agent. The optimum pH for the detection of Hg2+ by His-AuNPs was 12. The addition of Hg2+ to the His-AuNPs caused the color change from red to black-blue, which is readily detectable by the naked eye. This color change is followed by a decrease in the intensity of the primary Surface Plasmon Resonance (SPR) peak at a wavelength (λ) of 525 nm and an increase in the secondary peak at λ = 650 nm. His-AuNPs effectively detected Hg2+ with limits of detection and quantitation of 1.77 µM and 5.89 µM, respectively. His-AuNPs exhibited good performance for the detection of Hg2+ in waste water collected from a steel industrial facility in Banten Province, with a recovery and a percent relative standard deviation of 115% and 1.02%, respectively.

Associations of CYP2A6 Gene Polymorphism with Smoking Status Among Jordanians: Gender-Related Differences

2019 ◽  
Vol 20 (9) ◽  
pp. 765-770 ◽  
Author(s):  
Hana M. Hammad ◽  
Amer Imraish ◽  
Belal Azab ◽  
Al M. Best ◽  
Yousef S. Khader ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Smoking Status ◽  
Hepatic Enzyme ◽  
Nicotine Metabolism ◽  
Significant Frequency ◽  
Cytochrome P450 2A6 ◽  
Study Population ◽  
Major Metabolic Pathway ◽  
Cyp2a6 Gene

Background: Cytochrome P450 2A6 enzyme (CYP2A6), an essential hepatic enzyme involved in the metabolism of drugs, is responsible for a major metabolic pathway of nicotine. Variation in the activity of polymorphic CYP2A6 alleles has been implicated in inter-individual differences in nicotine metabolism. Aims: The objective of the current study was to assess the association between the smoking status and the cytochrome P450 2A6 enzyme (CYP2A6) genotype in Jordanians. Methods: In the current study, 218 (117 Male and 101 female) healthy unrelated Jordanian volunteers were recruited. CYP2A6*1B, CYP2A6*4 and CYP2A6*9 were determined and correlated with subject smoking status. Results: *1A/*1A was the most common genetic polymorphism in the overall study population, with no significant frequency differences between smokers and non-smokers. When the population was divided according to gender, only male smokers showed a significant correlation between genotype and smoking status. Considering the CYP2A6*9 genotype, the results showed differences in distribution between smokers and non-smokers, but only women showed a significant association between CYP2A6*9 allele genotype and smoking status. Conclusion: The results of this study show that there is a significant association between CYP2A6*9 genotype and smoking status. They also show that CYP2A6 genotype is significantly influenced by gender.

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