Combining a β3 adrenergic receptor agonist with alpha‐lipoic acid reduces inflammation in male mice with diet‐induced obesity

Obesity ◽  
2021 ◽  
Author(s):  
Zahraa Abdul Sater ◽  
Cheryl Cero ◽  
Anne E. Pierce ◽  
Hannah J. Lea ◽  
Houssein Abdul Sater ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Alpha Lipoic Acid ◽  
Male Mice ◽  
Diet Induced Obesity ◽  
Adrenergic Receptor Agonist

scholarly journals An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0168409 ◽  
Author(s):  
Megan D. Montgomery ◽  
Trevor Chan ◽  
Philip M. Swigart ◽  
Bat-erdene Myagmar ◽  
Rajesh Dash ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Male Mice ◽  
Doxorubicin Cardiomyopathy ◽  
Adrenergic Receptor Agonist

scholarly journals Strain-Specific Response toβ3-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice1

Endocrinology ◽  
1997 ◽  
Vol 138 (1) ◽  
pp. 405-413 ◽  
Author(s):  
Sheila Collins ◽  
Kiefer W. Daniel ◽  
Ann E. Petro ◽  
Richard S. Surwit
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Specific Response ◽  
Diet Induced Obesity ◽  
Adrenergic Receptor Agonist

Physiological Responses to Daily Use of Beta-Three Adrenergic Receptor Agonist, Mirabegron

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1146-P
Author(s):  
ALANA O'MARA ◽  
AARON CYPESS ◽  
CHERYL CERO ◽  
JAMES W. JOHNSON ◽  
JOYCE D. LINDERMAN ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Physiological Responses ◽  
Adrenergic Receptor Agonist

scholarly journals Long-acting β2-adrenergic receptor agonist in pediatric asthma

2004 ◽  
Vol 53 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Shigemi Yoshihara ◽  
Yumi Yamada ◽  
Toshio Abe ◽  
Osamu Arisaka
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Pediatric Asthma ◽  
Β2 Adrenergic Receptor ◽  
Long Acting ◽  
Adrenergic Receptor Agonist

scholarly journals Effect of Procaterol, a β2 Selective Adrenergic Receptor Agonist, on Airway Inflammation and Hyperresponsiveness

2007 ◽  
Vol 56 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Hiroyuki Tashimo ◽  
Naomi Yamashita ◽  
Hirofumi Ishida ◽  
Hiroyuki Nagase ◽  
Tetsuya Adachi ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Adrenergic Receptor Agonist

scholarly journals Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256768
Author(s):  
Patrick Munro ◽  
Samah Rekima ◽  
Agnès Loubat ◽  
Christophe Duranton ◽  
Didier F. Pisani ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Acute Infection ◽  
Immunomodulatory Activity ◽  
Inflammatory Parameters ◽  
Brown Adipose ◽  
Thermogenic Adipocytes ◽  
Adrenergic Receptor Agonist

White adipocytes store energy differently than brown and brite adipocytes which dissipate energy under the form of heat. Studies have shown that adipocytes are able to respond to bacteria thanks to the presence of Toll-like receptors at their surface. Despite this, little is known about the involvement of each class of adipocytes in the infectious response. We treated mice for one week with a β3-adrenergic receptor agonist to induce activation of brown adipose tissue and brite adipocytes within white adipose tissue. Mice were then injected intraperitoneally with E. coli to generate acute infection. The metabolic, infectious and inflammatory parameters of the mice were analysed during 48 hours after infection. Our results shown that in response to bacteria, thermogenic activity promoted a discrete and local anti-inflammatory environment in white adipose tissue characterized by the increase of the IL-1RA secretion. More generally, activation of brown and brite adipocytes did not modify the host response to infection including no additive effect with fever and an equivalent bacteria clearance and inflammatory response. In conclusion, these results suggest an IL-1RA-mediated immunomodulatory activity of thermogenic adipocytes in response to acute bacterial infection and open a way to characterize their effect along more chronic infection as septicaemia.

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