Dietary management of obesity‐associated neuropathy: Implications for clinical practice and trial design

Obesity ◽  
2021 ◽  
Author(s):  
A. Gordon Smith ◽  
J. Robinson Singleton
Keyword(s):  
Clinical Practice ◽  
Trial Design ◽  
Dietary Management

Extracranial-Intracranial Bypass for Stroke—Is This the End of the Line or a Bump in the Road?

Neurosurgery ◽  
2012 ◽  
Vol 71 (3) ◽  
pp. 557-561 ◽  
Author(s):  
◽  
Sepideh Amin-Hanjani ◽  
Fred G. Barker ◽  
Fady T. Charbel ◽  
E. Sander Connolly ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Medical Therapy ◽  
Trial Design ◽  
Carotid Occlusion ◽  
Design Study ◽  
Perioperative Morbidity ◽  
The Road ◽  
Future Developments ◽  
Study Population ◽  
Limited Application

Abstract The results of the recently published Carotid Occlusion Surgery Study, which failed to show a benefit of extracranial-intracranial (EC-IC) bypass over medical therapy in patients with symptomatic hemodynamically significant carotid occlusion, have been interpreted by some as the end of the line for EC-IC bypass in the management of stroke. Despite being carefully conceived and executed, several aspects of the trial design, study population, and underlying assumptions deserve further examination to determine how best to translate these results into clinical practice. Although a general expansion of EC-IC bypass use in this population would not be supported by the trial results, a select subset of patients with medically refractory hemodynamic symptoms may well benefit from surgery performed with sufficiently low perioperative morbidity. The potential for beneficial functional or cognitive impact of revascularization also remains under investigation. Limited application and further study with an eye to future developments, rather than complete abandonment, is warranted.

Trial design from a clinical perspective

ESC CardioMed ◽  
2018 ◽  
pp. 3067-3071
Author(s):  
John G. F. Cleland ◽  
Ian Ford
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Trial Design ◽  
Statistical Significance ◽  
Well Being ◽  
Phase Iii ◽  
Practical Significance ◽  
Commercial Company ◽  
Phase Iii Trials ◽  
General Guidance

This chapter is written primarily from the perspective of investigators with limited resources designing clinical trials to assess the effects of interventions on patient well-being and outcomes with the hope that the results might influence clinical practice and guidelines. Other perspectives should be taken into account. The advice may be less applicable when resources are abundant (e.g. phase III trials sponsored by a large commercial company). Much research is funded by commercial companies hoping for a return on investment; they will design clinical trials to increase the chance of a statistically positive result. Many investigators will do the same although their motivation may differ. However, practising clinicians, patients, and health services want trials that help inform their daily clinical practice rather than merely achieving statistical significance. Large studies may be statistically positive but of dubious practical significance. This chapter gives some general guidance on selecting patients, comparators, endpoints, and study design.

Incomplete Cross-Resistance Between Taxanes for Advanced Urothelial Carcinoma: Implications for Clinical Practice and Trial Design

2015 ◽  
Vol 13 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Guru Sonpavde ◽  
Gregory R. Pond ◽  
Stephanie Mullane ◽  
Angela Q. Qu ◽  
Giuseppe Di Lorenzo ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Urothelial Carcinoma ◽  
Trial Design ◽  
Cross Resistance ◽  
Advanced Urothelial Carcinoma

M1319 Do IBS Patients Understand the Difference Between Abdominal Pain vs. Discomfort? Implications for Clinical Practice and Clinical Trial Design

2010 ◽  
Vol 138 (5) ◽  
pp. S-379
Author(s):  
Brennan M. Spiegel ◽  
Roger E. Bolus ◽  
Lucinda A. Harris ◽  
Susan L. Lucak ◽  
Eric Esrailian ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Abdominal Pain ◽  
Clinical Practice ◽  
Trial Design ◽  
Clinical Trial Design ◽  
The Difference

Foundations of clinical practice

2011 ◽  
Author(s):  
Thomas Hughes
Keyword(s):  
Randomized Controlled Trial ◽  
Clinical Practice ◽  
Placebo Effect ◽  
Critical Review ◽  
Trial Design ◽  
Teaching And Learning ◽  
Controlled Trial ◽  
Clinical Governance ◽  
Review Of The Literature ◽  
Randomized Controlled

♦ Conscious and unconscious competency♦ Clinical research and the placebo effect♦ Trial design and the randomized controlled trial♦ Critical review of the literature♦ Clinical governance and audit♦ Capacity and consent♦ Principles of teaching and learning.

Intratumoral Immunotherapy: from Trial Design to Clinical Practice

2020 ◽  
pp. clincanres.0473.2020 ◽  
Author(s):  
Stephane Champiat ◽  
Lambros Tselikas ◽  
Siham FARHANE ◽  
Thibault Raoult ◽  
Matthieu Texier ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Trial Design

Outcomes for metastatic triple-negative (TN) breast cancer: Impact for clinical practice and trial design

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 1121-1121
Author(s):  
F. Kassam ◽  
K. Enright ◽  
R. Dent ◽  
C. Flynn ◽  
J. Myers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Practice ◽  
Trial Design ◽  
Triple Negative
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