High‐fat and high‐sodium diet induces metabolic dysfunction in the absence of obesity

Obesity ◽  
2021 ◽  
Author(s):  
Ryan A. Frieler ◽  
Thomas M. Vigil ◽  
Jianrui Song ◽  
Christy Leung ◽  
Carey N. Lumeng ◽  
...  
Keyword(s):  
Metabolic Dysfunction ◽  
High Fat ◽  
High Sodium ◽  
Sodium Diet ◽  
High Sodium Diet

scholarly journals The Main and Interactive Effects of Fat and Sodium Contents of the Diet on Characteristics of Metabolic Syndrome in Male Wistar Rats (P08-038-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Alireza Jahan-Mihan ◽  
Kea Schwarz ◽  
Leila Nynia ◽  
Tatyana Kimble
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
High Fat Diet ◽  
Sodium Content ◽  
Fat Content ◽  
High Fat ◽  
High Sodium ◽  
Sodium Diet ◽  
Male Wistar Rats ◽  
High Sodium Diet

Abstract Objectives The objective of this study was to investigate the main and interactive effects of fat and sodium content of the diet on food intake, body weight and composition, glucose metabolism and blood pressure in male Wistar rats. Methods Male Wistar Rats (n = 48, initial body weight: 115.30 ± 1.73 g) were allocated into 4 groups (n = 12/group) and received one of the following diets: Normal sodium normal fat (NSNF), normal sodium high fat (NSHF), high sodium normal fat (HSNF), high sodium high fat (HSHF) diet for 12 weeks. Body weight (BW) and food intake (FI) were measured weekly. Short-term food intake (1, 2 and 12 hours food intake after 12 hours fasting) was measured at week 6. Body composition and organs’ weight were measured at week 12. Systolic (SBP) and diastolic (DBP) blood pressure, pulse and fasting blood glucose (FBG) were measured and oral glucose tolerance test (OGTT) was conducted at weeks 1, 4, 8 and 12. Results Regardless of sodium content, a greater FI (both gram and cal) was observed in rats fed normal fat diet compared with those fed high fat diet. Consistently, FI (g) at 1, 2 and 12 hours was higher in rats fed a normal fat diet. However, no difference in calorie intake was observed at any time point. Higher BW and fat (%) was observed in high fat diet groups. Moreover, greater kidneys’ weights was observed in high sodium diet groups. Fasting blood glucose was higher in rats fed a normal sodium diet compared with those fed a high sodium diet while the tAUC glucose response to glucose preload was higher in rats fed a high fat diet compared with those fed a normal fat diet which is consistent with higher body weight in high fat diet groups. Regardless of fat content of the diet, pulse was higher in rats fed a high sodium diet compared with those fed a normal sodium diet. No effect of either dietary sodium or fat content of the diet on SBP or DBP was observed. Conclusions Fat but not sodium content of the diet is a determining factor in regulation of FI and BW. Moreover, both fat and sodium content of the diet influence the glucose metabolism potentially through different mechanisms. While pulse is influenced by sodium content, the results of this study do not support the effect of sodium or fat content of the diet on either SBP or DBP. Funding Sources UNF, Brooks College of Health internal grant.

P1-93 Prenatal hyperglycemia alters kallikrein activity response to high sodium diet in adult rats

2007 ◽  
Vol 83 ◽  
pp. S108
Author(s):  
S.P. Salas ◽  
A. Giacaman ◽  
F.J. Guarda ◽  
J. Acosta ◽  
C.P. Vío
Keyword(s):  
Adult Rats ◽  
High Sodium ◽  
Sodium Diet ◽  
Activity Response ◽  
Kallikrein Activity ◽  
High Sodium Diet

scholarly journals Effects of High Sodium Diet on Dopaminergic Mechanism in Normal and Hypertensive Subjects

1988 ◽  
Vol 64 (11) ◽  
pp. 1157-1168
Author(s):  
Masaki TAKAHASHI ◽  
Yukio MIURA ◽  
Naoki SANO ◽  
Takashi OHZEKI ◽  
Takashi SUGAWARA ◽  
...  
Keyword(s):  
High Sodium ◽  
Sodium Diet ◽  
Dopaminergic Mechanism ◽  
High Sodium Diet

scholarly journals INFLUENCE OF MATERNAL HIGH SODIUM DIET ON SYSTEMIC AND RENAL RENIN ANGIOTENSIN ALDOSTERONE SYSTEM OF MALES AND FEMALES OFFSPRING WISTAR RATS

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Débora Rothstein Ramos ◽  
Nauilo Lima Costa ◽  
Karen Lucasechi Lopes Jang ◽  
Ivone Braga Oliveira ◽  
Luzia Naoko Shinohara Furukawa
Keyword(s):  
Wistar Rats ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
High Sodium ◽  
Sodium Diet ◽  
Males And Females ◽  
High Sodium Diet

Upregulation of renal eNOS by high-sodium diet facilitates hypertension in doxorubicin-treated rats through enhanced oxidative stress

Toxicology ◽  
2006 ◽  
Vol 225 (2-3) ◽  
pp. 81-89 ◽  
Author(s):  
Toshihisa Hirai ◽  
Kenji Okumura ◽  
Yasuhiro Nishimoto ◽  
Takanori Shumiya ◽  
Ryuichiro Murakami ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Sodium ◽  
Sodium Diet ◽  
High Sodium Diet

Burden of high sodium diet in Brazilian population: Global Burden of Disease 2017 estimates

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
I Machado ◽  
L Guedes ◽  
M Felisbino-Mendes
Keyword(s):  
Burden Of Disease ◽  
Population Attributable Fraction ◽  
Mortality Rates ◽  
Brazilian Population ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
High Sodium ◽  
Sodium Diet ◽  
Life Years ◽  
High Sodium Diet

Abstract High-sodium diet leads to significant health problems such as high blood pressure, chronic kidney disease, ventricular hypertrophy and stroke. In Brazil, 2008 survey data have shown an average intake of 4.7 g/day of sodium, equivalent to 12 g/day of salt. In 2014, the average ofsalt intake estimated was 9.3 g/day. In both surveys, the numbers are higher than the international recommendation of 5g/day of salt. Considering this excessive consumption and the invisibility of the major consequences of such lifestyle, the aim of this study was to estimate the burden of diseases due to a high-sodium diet in Brazil. We used the high-sodium diet attributable disability-adjusted life-years (DALYs) and deaths estimates of the Global Burden of Disease study in 2017 among Brazilian. The burden of high-sodium diet was assessed using a comparative risk assessment approach, which allows the calculation of the population attributable fraction of each disease that has an established relation with this behavior. Input data from Brazil to reach such estimates have included surveys that report the dietary sodium. Data on disease occurrence and mortality were obtained from health information systems and health surveys. In 2017, high-sodium diet contributed with a significant number of deaths (51,434, 95% U.I.: 9,266-105,118) and DALYs (988,258, 95% U.I.: 139,943-2,149,179) in Brazil. The states of Northern Region presented lower mortality rates (Roraima: 11.1/100,000; 95% U.I.: 1.5-24.0 and Amapa: 10.6/100,000; 1.5-23.5), while those in the Southeast have higher mortality rates (Rio de Janeiro: 33.2/100,000; 95% U.I.: 5.4-68.1 and São Paulo: 32.0/100,000; 95% U.I.: 3.5-49.6). The same pattern by states was observed for DALYs. These findings are significant and support the urgent necessity of strategies to reinforce the promotion of a healthy diet, restricted in ultra-processed foods high in sodium, among the Brazilian population in order to prevent early morbidity and mortality. Key messages Salt consumption in Brazil is high and contributes to a significant number of deaths and DALYs. It is necessary to increase and reinforce actions that promote the Brazilian traditional food, such as the Brazilian Food Guide, and also the sodium reduction agreements with industries.

scholarly journals Sodium Intake and Heart Failure

2020 ◽  
Vol 21 (24) ◽  
pp. 9474
Author(s):  
Yash Patel ◽  
Jacob Joseph
Keyword(s):  
Heart Failure ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Mechanical Performance ◽  
Sodium Intake ◽  
Heart Association ◽  
Dietary Practices ◽  
High Sodium ◽  
Sodium Diet ◽  
High Sodium Diet

Sodium is an essential mineral and nutrient used in dietary practices across the world and is important to maintain proper blood volume and blood pressure. A high sodium diet is associated with increased expression of β—myosin heavy chain, decreased expression of α/β—myosin heavy chain, increased myocyte enhancer factor 2/nuclear factor of activated T cell transcriptional activity, and increased salt-inducible kinase 1 expression, which leads to alteration in myocardial mechanical performance. A high sodium diet is also associated with alterations in various proteins responsible for calcium homeostasis and myocardial contractility. Excessive sodium intake is associated with the development of a variety of comorbidities including hypertension, chronic kidney disease, stroke, and cardiovascular diseases. While the American College of Cardiology/American Heart Association/Heart Failure Society of America guidelines recommend limiting sodium intake to both prevent and manage heart failure, the evidence behind such recommendations is unclear. Our review article highlights evidence and underlying mechanisms favoring and contradicting limiting sodium intake in heart failure.

Sign in / Sign up

Export Citation Format

Share Document