Kynurenine‐Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia

Obesity ◽  
2021 ◽  
Vol 29 (2) ◽  
pp. 337-349
Author(s):  
Itzel Y. Rojas ◽  
Benjamin J. Moyer ◽  
Carol S. Ringelberg ◽  
Owen M. Wilkins ◽  
Darcy B. Pooler ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Body Mass ◽  
Liver Steatosis ◽  
Mass Gain ◽  
Receptor Signaling ◽  
Aryl Hydrocarbon ◽  
Body Mass Gain

Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats

2021 ◽  
Author(s):  
Keisuke Fukumura ◽  
Kenshiro Shikano ◽  
Yuaki Narimatsu ◽  
Eiko Iwakoshi-Ukena ◽  
Megumi Furumitsu ◽  
...  
Keyword(s):  
Food Intake ◽  
Feeding Behavior ◽  
Body Mass ◽  
Mass Gain ◽  
Chow Diet ◽  
Tissue Mass ◽  
Fat Accumulation ◽  
Intracerebroventricular Infusion ◽  
Body Mass Gain ◽  
Sucrose Diet

Abstract We recently identified a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), which is involved in energy homeostasis in birds and mammals. However, whether the action of NPGL is influenced by nutritional composition remains unknown. Thus, we investigated the effect of chronic intracerebroventricular infusion of NPGL for 13 days on feeding behavior and body mass gain under a normal chow diet (NC), high-fat diet, high-sucrose diet (HSD), and medium-fat/medium-sucrose diet (MFSD) in rats. NPGL stimulated food intake of NC and MFSD, especially during the light period. By contrast, NPGL decreased body mass gain under NC and increased total white adipose tissue mass in HSD- and MFSD-fed rats. These data suggest that the effects of NPGL on feeding behavior, body mass gain, and fat accumulation depend on nutrient type. Among them, sucrose in diets seems to contribute to fat accumulation elicited by NPGL.

Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling

2021 ◽  
Vol 70 ◽  
pp. 33-39
Author(s):  
Andreia Barroso ◽  
João V Mahler ◽  
Pedro H Fonseca-Castro ◽  
Francisco J Quintana
Keyword(s):  
Dendritic Cells ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Signaling ◽  
Aryl Hydrocarbon ◽  
Tolerogenic Dendritic Cells

scholarly journals A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility

2017 ◽  
Vol 27 (2) ◽  
pp. 57-69 ◽  
Author(s):  
Alexey V. Polonikov ◽  
Olga Yu. Bushueva ◽  
Irina V. Bulgakova ◽  
Maxim B. Freidin ◽  
Mikhail I. Churnosov ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Signaling Pathway ◽  
Receptor Signaling ◽  
Aryl Hydrocarbon ◽  
Receptor Signaling Pathway

scholarly journals Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

2008 ◽  
Vol 375 (3) ◽  
pp. 331-335 ◽  
Author(s):  
Christoph F.A. Vogel ◽  
Samuel R. Goth ◽  
Bin Dong ◽  
Isaac N. Pessah ◽  
Fumio Matsumura
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Signaling ◽  
Indoleamine 2,3 Dioxygenase ◽  
Aryl Hydrocarbon
Sign in / Sign up

Export Citation Format

Share Document