scholarly journals Low Serum Insulinlike Growth Factor II Levels Correlate with High BMI in American Indian Adults

Obesity ◽  
2020 ◽  
Vol 28 (3) ◽  
pp. 676-682
Author(s):  
Yunhua L. Muller ◽  
Robert L. Hanson ◽  
Darin Mahkee ◽  
Paolo Piaggi ◽  
Sayuko Kobes ◽  
...  
Keyword(s):  
Growth Factor ◽  
American Indian ◽  
Insulinlike Growth Factor ◽  
Factor Ii ◽  
High Bmi ◽  
Low Serum

scholarly journals The retinoblastoma gene product regulates Sp1-mediated transcription.

1992 ◽  
Vol 12 (6) ◽  
pp. 2455-2463 ◽  
Author(s):  
S J Kim ◽  
U S Onwuta ◽  
Y I Lee ◽  
R Li ◽  
M R Botchan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Product ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Control Element ◽  
Retinoblastoma Gene ◽  
Insulinlike Growth Factor ◽  
Factor Ii ◽  
Retinoblastoma Gene Product

We have demonstrated that the retinoblastoma gene product (Rb) can positively regulate transcription from the fourth promoter of the insulinlike growth factor II gene. Two copies of a motif (the retinoblastoma control element) similar to that found in the human c-fos, transforming growth factor beta 1, and c-myc promoters are responsible for conferring Rb regulation to the fourth promoter of the insulinlike growth factor II gene. We have shown that the transcription factor Sp1 can bind to and stimulate transcription from the retinoblastoma control element motif. Moreover, by using a GAL4-Sp1 fusion protein, we have directly demonstrated that Rb positively regulates Sp1 transcriptional activity in vivo. These results indicate that Rb can function as a positive regulator of transcription and that Sp1 is one potential target, either directly or indirectly, for transcriptional regulation by Rb.

The retinoblastoma gene product regulates Sp1-mediated transcription

1992 ◽  
Vol 12 (6) ◽  
pp. 2455-2463
Author(s):  
S J Kim ◽  
U S Onwuta ◽  
Y I Lee ◽  
R Li ◽  
M R Botchan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Product ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Control Element ◽  
Retinoblastoma Gene ◽  
Insulinlike Growth Factor ◽  
Factor Ii ◽  
Retinoblastoma Gene Product

We have demonstrated that the retinoblastoma gene product (Rb) can positively regulate transcription from the fourth promoter of the insulinlike growth factor II gene. Two copies of a motif (the retinoblastoma control element) similar to that found in the human c-fos, transforming growth factor beta 1, and c-myc promoters are responsible for conferring Rb regulation to the fourth promoter of the insulinlike growth factor II gene. We have shown that the transcription factor Sp1 can bind to and stimulate transcription from the retinoblastoma control element motif. Moreover, by using a GAL4-Sp1 fusion protein, we have directly demonstrated that Rb positively regulates Sp1 transcriptional activity in vivo. These results indicate that Rb can function as a positive regulator of transcription and that Sp1 is one potential target, either directly or indirectly, for transcriptional regulation by Rb.

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