Obesity Predicts Liver Function Testing and Abnormal Liver Results

Obesity ◽  
2019 ◽  
Vol 28 (1) ◽  
pp. 132-138 ◽  
Author(s):  
Wenhao Li ◽  
Kate Homer ◽  
Sally Hull ◽  
Kambiz Boomla ◽  
John Robson ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Testing ◽  
Function Testing

Liver Function Testing Is Not Helpful for Early Diagnosis of Metastatic Uveal Melanoma

Ophthalmology ◽  
2012 ◽  
Vol 119 (8) ◽  
pp. 1590-1595 ◽  
Author(s):  
Frédéric Mouriaux ◽  
Caroline Diorio ◽  
Dan Bergeron ◽  
Célia Berchi ◽  
Alain Rousseau
Keyword(s):  
Early Diagnosis ◽  
Liver Function ◽  
Uveal Melanoma ◽  
Liver Function Testing ◽  
Function Testing

scholarly journals Health outcomes following liver function testing in primary care: a retrospective cohort study

2009 ◽  
Vol 26 (4) ◽  
pp. 251-259 ◽  
Author(s):  
David J McLernon ◽  
Peter T Donnan ◽  
Stephen Ryder ◽  
Paul Roderick ◽  
Frank M Sullivan ◽  
...  
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Liver Function ◽  
Health Outcomes ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Liver Function Testing ◽  
Function Testing

scholarly journals A Paper-Based Multiplexed Transaminase Test for Low-Cost, Point-of-Care Liver Function Testing

2012 ◽  
Vol 4 (152) ◽  
pp. 152ra129-152ra129 ◽  
Author(s):  
N. R. Pollock ◽  
J. P. Rolland ◽  
S. Kumar ◽  
P. D. Beattie ◽  
S. Jain ◽  
...  
Keyword(s):  
Liver Function ◽  
Point Of Care ◽  
Low Cost ◽  
Liver Function Testing ◽  
Function Testing

scholarly journals Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic phenotyping and liver function testing

2021 ◽  
Author(s):  
Jan Grzegorzewski ◽  
Florian Bartsch ◽  
Adrian Köller ◽  
Matthias König
Keyword(s):  
Liver Function ◽  
Quality Data ◽  
Pharmacokinetic Parameters ◽  
Test Substance ◽  
Confounding Factors ◽  
Data Set ◽  
Metabolic Phenotyping ◽  
Systematic Analysis ◽  
Liver Function Testing ◽  
Function Testing

Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages. Caffeine is almost completely metabolized in the liver by the cytochrome P-450 enzyme system mainly to paraxanthine and the additional products theobromine and theophylline. Besides its stimulating properties, two important applications of caffeine are metabolic phenotyping of cytochrome P450 1A2 (CYP1A2) and liver function testing. An open challenge in this context is to identify underlying causes of the large inter-individual variability in caffeine pharmacokinetics. Data is urgently needed to understand and quantify confounding factors such as lifestyle (e.g. smoking), the effects of drug-caffeine interactions (e.g. medication metabolized via CYP1A2), and the effect of disease. Here we report the first integrative and systematic analysis of data on caffeine pharmacokinetics from 147 publications and provide a comprehensive high-quality data set on the pharmacokinetics of caffeine, caffeine metabolites, and their metabolic ratios in human adults. The data set is enriched by meta-data on the characteristics of studied patient cohorts and subjects (e.g. age, body weight, smoking status, health status), the applied interventions (e.g. dosing, substance, route of application), measured pharmacokinetic time-courses, and pharmacokinetic parameters (e.g. clearance, half-life, area under the curve). We demonstrate via multiple applications how the data set can be used to solidify existing knowledge and gain new insights relevant for metabolic phenotyping and liver function testing based on caffeine. Specifically, we analyzed (i) the alteration of caffeine pharmacokinetics with smoking and oral contraceptive use; (ii) drug-drug interactions with caffeine as possible confounding factors of caffeine pharmacokinetics or source of adverse effects; (iii) alteration of caffeine pharmacokinetics in disease; and (iv) the applicability of caffeine as a salivary test substance by comparison of plasma and saliva data. In conclusion, our data set and analyses provide important resources which could enable more accurate caffeine-based metabolic phenotyping and liver function testing.

Quantitative liver function testing as a preoperative parameter in hepatic resection

1994 ◽  
pp. 301-306
Author(s):  
Peter Lamesch ◽  
Burckhardt Ringe ◽  
Christian Rabe ◽  
Michael Oellerich ◽  
Martin Burdelski ◽  
...  
Keyword(s):  
Liver Function ◽  
Hepatic Resection ◽  
Liver Function Testing ◽  
Function Testing ◽  
Preoperative Parameter
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