scholarly journals Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity‐Prone and Resistant Adults

Obesity ◽  
2018 ◽  
Vol 26 (11) ◽  
pp. 1758-1766 ◽  
Author(s):  
Corey A. Rynders ◽  
Rocio I. Pereira ◽  
Audrey Bergouignan ◽  
Elizabeth H. Kealey ◽  
Daniel H. Bessesen
2017 ◽  
Vol 66 (2) ◽  
pp. 181-185 ◽  
Author(s):  
Yasutoshi Ando ◽  
Shinichiro Saito ◽  
Nami Yamanaka ◽  
Chizuka Suzuki ◽  
Takahiro Ono ◽  
...  

2005 ◽  
Vol 51 (2) ◽  
pp. 248-252 ◽  
Author(s):  
Ushio Harada ◽  
Akiro Chikama ◽  
Shinichiro Saito ◽  
Hideto Takase ◽  
Tomonori Nagao ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94181 ◽  
Author(s):  
Audrey Bergouignan ◽  
Elizabeth H. Kealey ◽  
Stacy L. Schmidt ◽  
Matthew R. Jackman ◽  
Daniel H. Bessesen

1999 ◽  
Vol 2 (3a) ◽  
pp. 341-347 ◽  
Author(s):  
Arne Astrup

AbstractObservational cross-sectional and longitudinal studies suggest that a high fat diet and physical inactivity are independent risk factors for weight gain and obesity. Mechanistic and intervention studies support that fat possesses a lower satiating power than carbohydrate and protein, and a diet low in fat therefore decreases energy intake. The effect of dietary fat on energy balance is enhanced in susceptible subjects, particularly in sedentary individuals with a genetic predisposition to obesity who consume a high fat diet.Dietary carbohydrate promotes its own oxidation by an insulin-mediated stimulation of glucose oxidation. In contrast, high fat meals do not increase fat oxidation acutely. A sedentary life-style and low physical fitness cause a low muscular fat oxidation capacity, and the consumption of a high fat diet by these individuals promotes fat storage in a synergistic fashion.Ad libitum low fat diets cause weight loss proportional to pre-treatment body weight in a dose-dependent way, i.e. weight loss is correlated positively to the reduction in dietary fat content. Increased physical activity prevents relapse after weight loss and studies have shown that those who keep up a higher level of physical activity are more successful in maintaining the reduced body weight. In conclusion, important interactions exist between genetic make up, dietary fat and physical fitness, so that a low fitness level and susceptible genes reduce muscular fat oxidation capacity which may decrease the tolerance of dietary fat. Increasing daily physical activity and reducing dietary fat content may be more effective when combined than when separate in preventing weight gain and obesity.


2008 ◽  
Vol 87 (1) ◽  
pp. 132-135 ◽  
Author(s):  
Klaas R Westerterp ◽  
Astrid Smeets ◽  
Manuela P Lejeune ◽  
Mirjam PE Wouters-Adriaens ◽  
Margriet S Westerterp-Plantenga

2019 ◽  
Vol 126 (4) ◽  
pp. 984-992 ◽  
Author(s):  
Nathan P. De Jong ◽  
Corey A. Rynders ◽  
David A. Goldstrohm ◽  
Zhaoxing Pan ◽  
Andrew H. Lange ◽  
...  

This study compared 24-h nutrient oxidation responses between a sedentary condition (SED) and a condition in which short 5-min bouts of moderate-intensity physical activity were performed hourly for nine consecutive hours over 4 days (MICRO). To determine whether any shifts in fuel use were due solely to increases in energy expenditure, we also studied a condition consisting of a single isoenergetic 45-min bout of moderate-intensity exercise (ONE). Twenty sedentary overweight or obese adults (10 men/10 women; 32.4 ± 6.3 yr; BMI, 30.6 ± 2.9 kg/m2) completed all three conditions (MICRO, SED, and ONE) in a randomized order. Each condition consisted of a 3-day free-living run-in followed by a 24-h stay in a whole-room calorimeter to measure total energy expenditure (TEE) and substrate utilization. Dietary fat oxidation was also assessed during the chamber stay by administering a [1-13C] oleic acid tracer at breakfast. Energy intake was matched across conditions. Both MICRO and ONE increased TEE relative to SED, resulting in a negative energy balance. HOMA-IR improved in both activity conditions. MICRO increased 24-h carbohydrate oxidation compared with both ONE and SED ( P < 0.01 for both). ONE was associated with higher 24-h total fat oxidation compared with SED, and higher 24-h dietary fat oxidation compared with both SED and MICRO. Differences in substrate oxidation remained significant after adjusting for energy balance. In overweight and obese men and women, breaking up sitting time increased reliance upon carbohydrate as fuel over 24 h, while a single energy-matched continuous bout of exercise preferentially relies upon fat over 24 h. NEW & NOTEWORTHY Insulin sensitivity, as assessed by HOMA-IR, was improved after 4 days of physical activity, independent of frequency and duration of activity bouts. Temporal patterns of activity across the day differentially affect substrate oxidation. Frequent interruptions of sedentary time with short bouts of walking primarily increase 24-h carbohydrate oxidation, whereas an energy-matched single continuous bout of moderate intensity walking primarily increased 24-h fat oxidation.


2004 ◽  
Vol 45 (12) ◽  
pp. 2339-2344 ◽  
Author(s):  
Aarthi Raman ◽  
Stephane Blanc ◽  
Alexandra Adams ◽  
Dale A. Schoeller

2008 ◽  
Vol 294 (4) ◽  
pp. E645-E653 ◽  
Author(s):  
Audrey Bergouignan ◽  
Dale A. Schoeller ◽  
Susanne Votruba ◽  
Chantal Simon ◽  
Stéphane Blanc

When using 13C tracer to measure plasma fat oxidation, an acetate recovery factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recovery factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate recovery factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 ± 5.4% dose ( n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in individual subjects. Moreover, the use of a group or individual correction did not affect the significant relationship found between fasting respiratory exchange ratio and dietary fat oxidation. These data indicate that an average dARF can be applied for longitudinal and cross-sectional studies investigating dietary lipid metabolism.


Author(s):  
Edwina Antoun ◽  
Iman Momken ◽  
Audrey Bergouignan ◽  
Clément Villars ◽  
Carine Platat ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document