scholarly journals Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity

Obesity ◽  
2016 ◽  
Vol 24 (12) ◽  
pp. 2544-2552 ◽  
Author(s):  
Marlies Bekaert ◽  
D. Margriet Ouwens ◽  
Tina Hörbelt ◽  
Frederique Van de Velde ◽  
Pia Fahlbusch ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Visceral Adipose

scholarly journals Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis

Sci ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 13
Author(s):  
Raine Toivonen ◽  
Sanja Vanhatalo ◽  
Maija Hollmén ◽  
Eveliina Munukka ◽  
Anniina Keskitalo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Leukocyte Infiltration ◽  
Fat Accumulation ◽  
Adhesion Protein ◽  
Hepatic Fat ◽  
Vascular Adhesion ◽  
Visceral Adipose ◽  
Vascular Adhesion Protein 1

Toll-like receptor 5 ligand, flagellin, and vascular adhesion protein 1 (VAP-1) are involved in non-alcoholic fatty liver disease. This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation. The effects of flagellin on adipocyte VAP-1 expression were first studied in vitro. Then, flagellin (100 ng/mouse) or saline was intraperitoneally injected into C57BL/6J (WT) and C57BL/6-Aoc3-/- (VAP-1 KO) mice on a high-fat diet twice a week every 2 weeks for 10 weeks. After that, the effects on inflammation, insulin signaling, and metabolism were studied in liver and adipose tissues. Hepatic fat was quantified histologically and biochemically. Because flagellin challenge increased VAP-1 expression in human adipocytes, we used VAP-1 KO mice to determine whether VAP-1 regulates the inflammatory and metabolic effects of flagellin in vivo. In mice, VAP-1 mediated flagellin-induced inflammation, leukocyte infiltration, and lipolysis in visceral adipose tissue. Consequently, an increased release of glycerol led to hepatic steatosis in WT, but not in KO mice. Flagellin-induced hepatic fibrosis was not mediated by VAP-1. VAP-1 KO mice harbored more inflammation-related microbes than WT mice, while flagellin did not affect the gut microbiota. Our results suggest that by acting on visceral adipose tissue, flagellin increased leukocyte infiltration that induced lipolysis. Further, the released glycerol participated in hepatic fat accumulation. In conclusion, the results describe that gut microbial flagellin through VAP-1 induced hepatic steatosis.

scholarly journals Erratum to: SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

2010 ◽  
Vol 20 (6) ◽  
pp. 831-831
Author(s):  
Cíntia dos Santos Costa ◽  
Thais Ortiz Hammes ◽  
Francieli Rohden ◽  
Rogério Margis ◽  
Josiane Woutheres Bortolotto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Visceral Adipose

scholarly journals ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

2017 ◽  
Vol 49 (05) ◽  
pp. 343-349 ◽  
Author(s):  
Christian von Loeffelholz ◽  
Andreas Pfeiffer ◽  
Johan Lock ◽  
Steffi Lieske ◽  
Stephanie Döcke ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Visceral Adipose

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

2009 ◽  
Vol 20 (5) ◽  
pp. 633-639 ◽  
Author(s):  
Cíntia dos Santos Costa ◽  
Thais Ortiz Hammes ◽  
Francieli Rohden ◽  
Rogério Margis ◽  
Josiane Woutheres Bortolotto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Visceral Adipose

scholarly journals Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis

Sci ◽  
2019 ◽  
Vol 1 (3) ◽  
pp. 65 ◽  
Author(s):  
Toivonen ◽  
Vanhatalo ◽  
Hollmén ◽  
Munukka ◽  
Keskitalo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Leukocyte Infiltration ◽  
Fat Accumulation ◽  
Adhesion Protein ◽  
Hepatic Fat ◽  
Vascular Adhesion ◽  
Visceral Adipose ◽  
Vascular Adhesion Protein 1

Toll-like receptor 5 ligand, flagellin, and Vascular Adhesion Protein-1 (VAP-1) are involved in non-alcoholic fatty liver disease (NAFLD). This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation. The effects of flagellin on adipocyte VAP-1 expression were first studied in vitro. Then, flagellin (100 ng/mouse) or saline was intraperitoneally injected to C57BL/6J WT and C57BL/6-Aoc3-/- (VAP-1 KO) mice on high-fat diet twice a week every two weeks for 10-weeks. After that, the effects on inflammation, insulin signaling, and metabolism were studied in liver and adipose tissues. Hepatic fat was quantified histologically and biochemically. Because flagellin challenge increased VAP-1 expression in human adipocytes, we used VAP-1 KO mice to determine whether VAP-1 regulates the inflammatory and metabolic effects of flagellin in vivo. In mice, VAP-1 mediated flagellin-induced inflammation, leukocyte infiltration and lipolysis in visceral adipose tissue. Consequently, increased release of glycerol led to hepatic steatosis in WT but not KO mice. Flagellin-induced hepatic fibrosis was not mediated by VAP-1. VAP-1 KO mice harbored more inflammation-related microbes than WT, while flagellin did not affect the gut microbiota. Our results suggest that by acting on visceral adipose tissue, flagellin increased leukocyte infiltration that induced lipolysis. Further, the released glycerol participated in hepatic fat accumulation. In conclusion, the results describe that gut microbial flagellin through VAP-1 induced hepatic steatosis.

scholarly journals Visceral adipose tissue area is an independent risk factor for hepatic steatosis

2008 ◽  
Vol 23 (6) ◽  
pp. 900-907 ◽  
Author(s):  
Bum J Park ◽  
Yoon J Kim ◽  
Dong H Kim ◽  
Won Kim ◽  
Yong J Jung ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Risk Factor ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Independent Risk Factor ◽  
Tissue Area ◽  
Visceral Adipose

scholarly journals Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in obese patients

2016 ◽  
Author(s):  
Marlies Bekaert ◽  
Ouwens D Margriet ◽  
Tina Horbelt ◽  
de Velde Frederique Van ◽  
Nieuwenhove Yves Van ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Visceral Adipose Tissue ◽  
Obese Patients ◽  
Visceral Adipose

Lack of association between colorectal adenoma recurrence and visceral adipose tissue

2001 ◽  
Vol 120 (5) ◽  
pp. A254-A254
Author(s):  
D SASS ◽  
R SCHOEN ◽  
J WEISSFELD ◽  
L KULLER ◽  
F THAETE ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Colorectal Adenoma ◽  
Visceral Adipose Tissue ◽  
Adenoma Recurrence ◽  
Colorectal Adenoma Recurrence ◽  
Visceral Adipose
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