scholarly journals Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity

Obesity ◽  
2016 ◽  
Vol 24 (3) ◽  
pp. 597-605 ◽  
Author(s):  
Lindsey A. Muir ◽  
Christopher K. Neeley ◽  
Kevin A. Meyer ◽  
Nicki A. Baker ◽  
Alice M. Brosius ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Human Obesity ◽  
Tissue Fibrosis

Adipose Tissue and Circulating Endothelial Cell Specific Molecule-1 in Human Obesity

2006 ◽  
Vol 38 (1) ◽  
pp. 28-33 ◽  
Author(s):  
J. Janke ◽  
S. Engeli ◽  
K. Gorzelniak ◽  
M. Feldpausch ◽  
U. Heintze ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Endothelial Cell ◽  
Human Obesity

Periostin deficiency attenuates lipopolysaccharide‐ and obesity‐induced adipose tissue fibrosis

FEBS Letters ◽  
2021 ◽  
Author(s):  
Yuhan Yang ◽  
Yanfei Zhang ◽  
Xueliang Zhou ◽  
Dandan Chen ◽  
Gaoliang Ouyang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Tissue Fibrosis

scholarly journals Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation

2010 ◽  
Vol 24 (3) ◽  
pp. 680-680
Author(s):  
Nadia Naour ◽  
Christine Rouault ◽  
Soraya Fellahi ◽  
Marie-Eve Lavoie ◽  
Christine Poitou ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Cathepsin S ◽  
Human Obesity

Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity

2002 ◽  
Vol 282 (1) ◽  
pp. E46-E51 ◽  
Author(s):  
Frédérique Diraison ◽  
Eric Dusserre ◽  
Hubert Vidal ◽  
Monique Sothier ◽  
Michel Beylot
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Synthase ◽  
Regulatory Element ◽  
Energy Restriction ◽  
Mrna Levels ◽  
Hepatic Lipogenesis ◽  
Deuterated Water ◽  
Human Obesity ◽  
Fas Mrna ◽  
Obese Subjects

To determine whether increased lipogenesis contributes to human obesity, we measured (postabsorptive state), in lean and obese subjects, lipid synthesis (deuterated water method) and the mRNA concentration (RT-competitive PCR) in subcutaneous adipose tissue of fatty acid synthase (FAS) and sterol regulatory element-binding protein (SREBP)-1c. Before energy restriction, obese subjects had an increased contribution of hepatic lipogenesis to the circulating triglyceride pool (14.5 ± 1.3 vs. 7.5 ± 1.9%, P < 0.01) without enhancement of cholesterol synthesis. This increased hepatic lipogenesis represented an excess of 2–5 g/day of triglycerides, which would represent 0.7–1.8 kg on a yearly basis. The lipogenic capacity of adipose tissue appeared, on the contrary, decreased with lower FAS mRNA levels ( P < 0.01) and a trend for decreased SREBP-1c mRNA ( P = 0.06). Energy restriction in obese patients decreased plama insulin ( P < 0.05) and leptin ( P < 0.05) and normalized hepatic lipogenesis. FAS mRNA levels were unchanged, whereas SREBP-1c increased. In conclusion, subjects with established obesity have an increased hepatic lipogenesis that could contribute to their excessive fat mass but no evidence for an increased lipogenic capacity of adipose tissue.

Exercise training attenuates adipose tissue fibrosis in diet-induced obese mice

2013 ◽  
Vol 440 (4) ◽  
pp. 774-779 ◽  
Author(s):  
Noriaki Kawanishi ◽  
Hiroyuki Niihara ◽  
Tsubasa Mizokami ◽  
Hiromi Yano ◽  
Katsuhiko Suzuki
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
Obese Mice ◽  
Tissue Fibrosis
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