scholarly journals MFAP5is related to obesity-associated adipose tissue and extracellular matrix remodeling and inflammation

Obesity ◽  
2015 ◽  
Vol 23 (7) ◽  
pp. 1371-1378 ◽  
Author(s):  
Maija Vaittinen ◽  
Marjukka Kolehmainen ◽  
Mikael Rydén ◽  
Matti Eskelinen ◽  
Martin Wabitsch ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity

Diabetes ◽  
2016 ◽  
Vol 65 (8) ◽  
pp. 2295-2310 ◽  
Author(s):  
Ting Luo ◽  
Allison Nocon ◽  
Jessica Fry ◽  
Alex Sherban ◽  
Xianliang Rui ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Ampk Activation

scholarly journals Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss

Diabetes ◽  
2016 ◽  
Vol 65 (12) ◽  
pp. 3636-3648 ◽  
Author(s):  
Victoria Catalán ◽  
Javier Gómez-Ambrosi ◽  
Amaia Rodríguez ◽  
Beatriz Ramírez ◽  
Víctor Valentí ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases

2019 ◽  
Vol 20 (19) ◽  
pp. 4888 ◽  
Author(s):  
Ruiz-Ojeda ◽  
Méndez-Gutiérrez ◽  
Aguilera ◽  
Plaza-Díaz
Keyword(s):  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Metabolic Diseases ◽  
Tissue Expansion ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Ecm Remodeling ◽  
Survival And Development ◽  
Tissue Receptors

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that controls differentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases.

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