scholarly journals Maternal obesity or weight loss around conception impacts hepatic fatty acid metabolism in the offspring

Obesity ◽  
2014 ◽  
Vol 22 (7) ◽  
pp. 1685-1693 ◽  
Author(s):  
Lisa M. Nicholas ◽  
Leewen Rattanatray ◽  
Janna L. Morrison ◽  
David O. Kleemann ◽  
Simon K. Walker ◽  
...  
Keyword(s):  
Weight Loss ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Maternal Obesity ◽  
Acid Metabolism ◽  
Hepatic Fatty Acid

scholarly journals ETV5 regulates hepatic fatty acid metabolism through PPAR signaling pathway

2020 ◽  
Author(s):  
Ada Admin ◽  
Zhuo Mao ◽  
Mingji Feng ◽  
Zhuoran Li ◽  
Minsi Zhou ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Association Studies ◽  
Sequencing Analysis ◽  
Dependent Manner ◽  
Alcoholic Fatty Liver ◽  
Hepatic Fatty Acid ◽  
Ppar Signaling

ETV5 is an ETS transcription factor which has been associated with obesity in genomic association studies. However, little is known about the role of ETV5 in hepatic lipid metabolism and non-alcoholic fatty liver disease (NAFLD). In the present study, we found that ETV5 protein expression was increased in diet- and genetic-induced steatotic liver. ETV5 responded to the nutrient status in an mTORC1 dependent manner and in turn regulated mTORC1 activity. Both viral-mediated and genetic depletion of ETV5 in mice led to increased lipid accumulation in the liver. RNA sequencing analysis revealed that PPAR signaling and fatty acid degradation/metabolism pathways were significantly downregulated in ETV5 deficient hepatocytes <i>in vivo</i> and <i>in vitro. </i>Mechanistically, ETV5 could bind to the PPRE region of PPAR downstream genes and enhance its transactivity. Collectively, our study identifies ETV5 as a novel transcription factor for the regulation of hepatic fatty acid metabolism which is required for the optimal β oxidation process. ETV5 may provide a therapeutic target for the treatment of hepatic steatosis.<br>

Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats

2012 ◽  
Vol 52 (3) ◽  
pp. 1015-1027 ◽  
Author(s):  
Takashi Ide ◽  
Ayana Azechi ◽  
Sayaka Kitade ◽  
Yoko Kunimatsu ◽  
Natsuko Suzuki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Lipoic Acid ◽  
Acid Metabolism ◽  
Combined Effect ◽  
Hepatic Fatty Acid

Hepatic Fatty Acid Metabolism as a Determinant of Plasma and Liver Triacylglycerol Levels. Studies on Tetradecylthioacetic and Tetradecylthiopropionic Acids

1995 ◽  
Vol 227 (3) ◽  
pp. 715-722 ◽  
Author(s):  
Daniel K. Asiedu ◽  
Ayman Al-Shurbaji ◽  
Arild C. Rustan ◽  
Ingemar Bjorkhem ◽  
Lars Berglund ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Hepatic Fatty Acid

Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats

2011 ◽  
Vol 1811 (7-8) ◽  
pp. 441-451 ◽  
Author(s):  
Jolita Ciapaite ◽  
Nicole M. van den Broek ◽  
Heleen te Brinke ◽  
Klaas Nicolay ◽  
Jeroen A. Jeneson ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
High Fat Diet ◽  
Acid Metabolism ◽  
High Fat ◽  
Differential Effects ◽  
Hepatic Fatty Acid ◽  
Short And Long Term

Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats

Hepatology ◽  
1992 ◽  
Vol 15 (6) ◽  
pp. 1099-1106 ◽  
Author(s):  
Fumihiro Nozu ◽  
Naoshi Takeyama ◽  
Takaya Tanaka
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Hepatic Fatty Acid

Effects of lovastatin on hepatic fatty acid metabolism

Lipids ◽  
1993 ◽  
Vol 28 (12) ◽  
pp. 1087-1093 ◽  
Author(s):  
Manuel Guzmán ◽  
Josefa P. Cortés ◽  
José Castro
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Hepatic Fatty Acid
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